DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNB1 and Shab

DIOPT Version :9

Sequence 1:	NP_004966.1	Gene:	KCNB1 / 3745	HGNCID:	6231	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	432/992 - (43%)
Similarity:	569/992 - (57%)	Gaps:	184/992 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    10 SRSTSSL-PPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVC 73
            |||.||: ||||..|.:|||.:.||.:||||:.||||||||:|||.||||:||:|.||::::|:|
  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349

Human    74 DDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYH 138
            |||||.||||||||||.:|:|||||||||:||:::|||.|:||.:|:|||:||:|||||||.:||
  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414

Human   139 QKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203
            |:||.::||:::|||:||:|:.|||....|||.:|.||:||||||:|.||:::|:|||:||||||
  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479

Human   204 IALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLL 268
            |||:|||||:||.:|. |...||||||.||||||.|||:||:|||.:||.|||||||.||.||||
  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543

Human   269 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 332
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608

Human   333 LLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLC 397
            ||:||||||::|||||.:||||||.||||.|||.:||||.|||||||||||||.|.|||::|.:|
  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673

Human   398 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNMKDAFARSIE 459
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|:|||||:|::
  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738

Human   460 MMDIVVE--KNGENMGKKDKVQDNHLSPNKWKWT----------------KRTLSETSSSKSFET 506
            ::|::|:  |....:..|.|.|.   :||..:.|                ..|..|::|.::..|
  Fly   739 LIDVIVDTGKQTNVVHPKGKRQS---TPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPAT 800

Human   507 KEQG--------------SPEKARSSSSPQ---------HLNVQQLEDMYNKMAKTQSQPILNTK 548
            ...|              :....|.|||.|         :.|.:|...|..:..:.:.|.:|..:
  Fly   801 TGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQ 865

Human   549 ESAAQSKPKEELEMESI--PSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLTS 611
                |.:.::.|:|:.|  .:|.........||.:..:|.:..   |.||....||..|::
  Fly   866 ----QQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAAS---SAATAVATATNASNA---- 919

Human   612 LPSKTGGSTAPEVGWRGALGASGGRFVEANPSPD--ASQHSSFFIE---SPKSSMKTNNPLKLRA 671
                  .:|||     |:.||.||...:.....|  .||.....|:   :|....:....:.|..
  Fly   920 ------SNTAP-----GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALEN 973

Human   672 L---KVNFMEGDPSPLLPV-------------------------LGMYHDP--LRNRGSAAAAVA 706
            |   :::.:|.|    :||                         ...:|.|  |..|.:||...|
  Fly   974 LQNQRMDNLEQD----VPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQA 1034

Human   707 G------------------------------LECATLLDKAV--LSPESSIYTTASAKT---PPR 736
            |                              ..||.:|..|:  .|..||.|.|.::.|   |..
  Fly  1035 GAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTTIALPLD 1099

Human   737 SPEKHTAI---AFNFEAGVHQYIDADT---DDEGQLLY---------------SVDSSPPKSLPG 780
            ...::.|.   :.||....:...:..|   ...|.||:               |||||...: ..
  Fly  1100 VSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSSDTYA-SC 1163

Human   781 STSPKFSTGTRSEKNHFESSPLPTSPKFL---------RQNCIYSTEALTG---KGPSGQEKCKL 833
            .|.|..|.|..:...:.|:..|......|         .|....||..:.|   ...||..:.::
  Fly  1164 QTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGFIVGLPSTNSSGGPRAQV 1228

Human   834 ENHISPD--VRVLPGGG 848
            :...|.|  :|.|..||
  Fly  1229 KKSASGDTALRNLAAGG 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNB1	NP_004966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		8/11 (73%)
		BTB_POZ_KCNB2	15..141	CDD:349719	86/126 (68%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	59..75		7/15 (47%)
		Ion_trans	188..424	CDD:395416	181/236 (77%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	448..481		13/34 (38%)
		Kv2channel	467..679	CDD:397541	51/260 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..524		16/91 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..574		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..807		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..858		6/15 (40%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	75/106 (71%)
		BTB_2	309..408	CDD:280393	69/98 (70%)
		Ion_trans	501..700	CDD:278921	157/198 (79%)
		Ion_trans_2	613..696	CDD:285168	65/82 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I956
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I751
Isobase	1	0.950	-	0	Normalized mean entropy	S4489
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm41959
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3999
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.840