DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp14 and fkbp6

DIOPT Version :9

Sequence 1:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001122145.1	Gene:	fkbp6 / 402839	ZFINID:	ZDB-GENE-050302-4	Length:	343	Species:	Danio rerio

Alignment Length:	175	Identity:	42/175 - (24%)
Similarity:	79/175 - (45%)	Gaps:	37/175 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGD 110
            |::::::|.::.....|:::.....|...:||....:.|.:.|||.|..||..:....|:..|||
Zfish    62 SVSINFSGFIEYTDAPFETTNHLKYPRMMKLGKDVTLYGLELGLLTMKKGEFSRFLFKPKYAYGD 126

  Fly   111 QGAGNVIPPKATLLFDVELINIGNAPPTTNVFKEIDDNADKQLSRE-----EVIVYV-------- 162
            .|....|||.||:|::|::::..::       .::||..|..|..:     .|::.|
Zfish   127 LGCPPHIPPCATVLYEVQVLDFLDS-------AQVDDFMDLTLEEQNTAPLSVLLNVLDTQRSFG 184

  Fly   163 ------------SEYLKKQMTAVEGQDSEELKNMLAENDKLVEEI 195
                        .|..|:.||.::.::.|:     ||..|.:|||
Zfish   185 NLCFNKKRYEDARERYKQAMTLLQNREPED-----AEEKKHLEEI 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	25/83 (30%)
		EF-hand_7	140..212	CDD:290234	17/81 (21%)
		EFh	141..212	CDD:298682	17/80 (21%)
fkbp6	NP_001122145.1	FKBP_C	63..146	CDD:278674	24/82 (29%)
		TPR_12	174..258	CDD:290160	12/56 (21%)
		TPR repeat	214..255	CDD:276809	6/16 (38%)
		TPR_11	228..291	CDD:290150
		TPR repeat	260..286	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900