DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp14 and fkbp8

DIOPT Version :9

Sequence 1:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_957178.1	Gene:	fkbp8 / 393858	ZFINID:	ZDB-GENE-040426-1849	Length:	406	Species:	Danio rerio

Alignment Length:	192	Identity:	49/192 - (25%)
Similarity:	79/192 - (41%)	Gaps:	33/192 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LKVEVISTPEVCEQKSKNGDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLL 90
            |:.:|:......:.:.:.|.::|:|.. |...:|...|...|    .:|.||.|.|::..|..:.
Zfish    94 LRKKVLEAGAGPDSRPQKGQNVTIHLK-TALTNGTVVDELKD----LSFTLGDGDVLQALDLTVQ 153

  Fly    91 NMCVGEKRKLTIPPQLGYGDQG-AGNVIPPKATLLFDVELINIGNA------PPTTNVF----KE 144
            .|.:|||..:....:..||..| :...:||.|.||.:|:|::...|      ||:..:.    |.
Zfish   154 LMEMGEKALIEAAAKYAYGALGSSAPAVPPDADLLLEVQLLSADEALDLELMPPSERIILANRKR 218

  Fly   145 IDDNADKQLSREEVIVYVSEY-LKKQMTAVE-----GQDSEE---------LKNMLAENDKL 191
            ...|...|  |.:....|:.| :..|:|...     .|:.||         |.||.|...||
Zfish   219 ERGNVHYQ--RADYAFAVNSYGIALQITEASSRVDISQEEEEELLDMKVKCLNNMAAAQLKL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	26/93 (28%)
		EF-hand_7	140..212	CDD:290234	17/71 (24%)
		EFh	141..212	CDD:298682	17/70 (24%)
fkbp8	NP_957178.1	FKBP_C	106..194	CDD:278674	26/92 (28%)
		TPR_11	214..296	CDD:290150	17/67 (25%)
		TPR repeat	214..259	CDD:276809	10/46 (22%)
		TPR repeat	265..293	CDD:276809	6/14 (43%)
		TPR_11	266..330	CDD:290150	6/13 (46%)
		TPR repeat	298..328	CDD:276809
		TPR_1	299..332	CDD:278916
		TPR repeat	333..361	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900