DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp14 and fkbp4

DIOPT Version :9

Sequence 1:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	XP_005173673.1	Gene:	fkbp4 / 321795	ZFINID:	ZDB-GENE-030131-514	Length:	450	Species:	Danio rerio

Alignment Length:	188	Identity:	69/188 - (36%)
Similarity:	93/188 - (49%)	Gaps:	35/188 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GDSLTMHYTGTLQADGKKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGY 108
            ||.:.:||.||| .||.:||||.||.:.|:|:||.|||||.||.|:..|.:||..:||..|:..|
Zfish    45 GDKVFVHYVGTL-LDGSQFDSSRDRGEKFSFELGKGQVIKAWDIGVATMKIGEICQLTCKPEYAY 108

  Fly   109 GDQGAGNVIPPKATLLFDVELINIGNAPPTTNVFKEIDDNADKQLSREEVIVYVSEYLKKQMTA- 172
            |..|:...|||.|||||.|||.:...        ::|.|:.|..::| .:|.....|.|....|
Zfish   109 GAAGSPPKIPPNATLLFQVELFDFRG--------EDITDDEDGGITR-RIITKGEGYTKPNEGAT 164

  Fly   173 ----VEGQ------DSEELKNMLAENDKL-----VEEIFQHED---------KDKNGF 206
                :||.      |..|||..:.:.:.|     ||:..|..:         |.|.||
Zfish   165 VEVWLEGSHEDRVFDERELKFEVGDGENLGLPLGVEKALQAMEQGEEALFTIKPKYGF 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	46/85 (54%)
		EF-hand_7	140..212	CDD:290234	22/92 (24%)
		EFh	141..212	CDD:298682	22/91 (24%)
fkbp4	XP_005173673.1	FKBP_C	38..129	CDD:278674	45/84 (54%)
		ppisom_GldI	<153..249	CDD:132555	17/70 (24%)
		TPR repeat	269..293	CDD:276809
		TPR_16	270..348	CDD:290168
		TPR repeat	305..343	CDD:276809
		TPR_11	316..379	CDD:290150
		TPR_1	316..347	CDD:278916
		TPR repeat	348..376	CDD:276809
		TPR_1	349..381	CDD:278916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810