Protein Alignment Sdc and SDC3

DIOPT Version :9

• Sequence 1: NP_001163238.2
• Gene: Sdc / 37447
• FlyBaseID: FBgn0010415
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_055469.3
• Gene: SDC3 / 9672
• HGNCID: 10660
• Length: 442
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 124/518 - (23%)
• Similarity: 182/518 - (35%)
• Gaps: 142/518 - (27%)

  Fly    11 PLLLVAILIGVLVAATHAQDQKSVKPSAAAPSAAASRPHDEIYIDDDSIEGSGGRGGIHEDLEKD 75
            ||||:.:                     |..:|.|.|...|.:.....:||||......:| |.|
Human    34 PLLLLLL---------------------AGRAAGAQRWRSENFERPVDLEGSGDDDSFPDD-ELD 76

  Fly    76 PDYSGSGFGPDDEDA--------EPDQHSHSSHNTRISQSSN-SGINSKHNSNENYGKNSKNSNS 131
            ..|||||.|..::::        .||.....|....:..::| ..:.:......:.....:.:.|
Human    77 DLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATS 141

  Fly   132 DLISSRFNNNNNHNQIDNSQNINLNPNNNHQTNSGTIIGSSTTANNNNNHNININSQNGIISGSG 196
            .|:.:               .:...|:....|.|.|:   :|||
Human   142 PLVVT---------------EVPEEPSQRATTVSTTM---ATTA--------------------- 167

  Fly   197 SDIGGHSTGINSIAAHTPTQTSSTIP-TTSTSTPMPTTTPTATTPASTTTAAATQISSFANSSST 260
                         |..|...|.:|:| |.:|:||   :||.|  |..|.|.|..:.:........
Human   168 -------------ATSTGDPTVATVPATVATATP---STPAA--PPFTATTAVIRTTGVRRLLPL 214

  Fly   261 TTTTLAPTIPAEPQQPLFPPFDKDLDTESSGDGIDADAEDDDEDDGDDKDYDYNKELDK-----E 320
            ..||:|......|:.|..|.....||||:....:.:.|....            :.|.:     |
Human   215 PLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRP------------RALPRPATTQE 267

  Fly   321 IDIDGPEPGHLP-PVVHHNTVETGHIPTTD----------EIDVDGGDEDDNGDSDIDGPRIGGN 374
            .||  ||...|| ........|....||.:          |:.|.||   .:||.::  |.....
Human   268 PDI--PERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGG---PSGDFEL--PEEETT 325

  Fly   375 DGDITERGPGAGGSNVHELDPNTNVNSQPSDTKGIDHRPNGNEVVIMSEDDRTS-------SFFS 432
            ..|........||:....        |.|..|.....|| |..::..:.|..:|       |...
Human   326 QPDTANEVVAVGGAAAKA--------SSPPGTLPKGARP-GPGLLDNAIDSGSSAAQLPQKSILE 381

  Fly   433 QPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPANNSYAKNANNREFYA 495
            :..:|.|||.|.|||.|.|..:|..::|||:|||||||.|:|||:  |:.:|.|.....||||
Human   382 RKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQ--ASVTYQKPDKQEEFYA 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sdc	NP_001163238.2	Syndecan	429..493	CDD:279386	29/63 (46%)
SDC3	NP_055469.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..87		13/30 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..173		9/59 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..326		26/119 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..367		6/35 (17%)
		Syndecan	<399..440	CDD:279386	19/42 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..442		10/24 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142169
Domainoid	1	1.000	63	1.000	Domainoid score	I10249
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	78	1.000	Inparanoid score	I5250
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10915
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7285
SonicParanoid	1	1.000	-	-		X6774
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.110