DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdc and Sdc3

DIOPT Version :9

Sequence 1:	NP_001163238.2	Gene:	Sdc / 37447	FlyBaseID:	FBgn0010415	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_446345.3	Gene:	Sdc3 / 116673	RGDID:	621486	Length:	442	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	124/526 - (23%)
Similarity:	175/526 - (33%)	Gaps:	156/526 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLLLVAILIGVLVAATHAQDQKSVKPSAAAPSAAASRPHDEIYIDDDSIEGSGGRGGIHEDLEKD 75
            ||||:.:                     |..:|.|.|..:|.:.....:||||......:| |.|
  Rat    32 PLLLLLL---------------------AGRAAGAQRWRNENFERPVDLEGSGDDDSFPDD-ELD 74

  Fly    76 PDYSGSGFG---------------PDDEDAEPDQHSHSSHNTRISQSSNSGIN---SKHNSNENY 122
            ..|||||.|               ||...|.|.  :.:...|.:.|..::...   |:|...|..
  Rat    75 DLYSGSGSGYFEQESGLETAMRFIPDIALAAPT--APAMLPTTVIQPVDTPFEELLSEHPGPEPV 137

  Fly   123 GKNSKNSNSDLISSRFNNNNNHNQIDNSQNINLNPNNNHQTNSGTIIGSSTTANNNNNHNININS 187
                  ::..|::             ....:...|:....|.|.|   :||||
  Rat   138 ------TSPPLVT-------------EVTEVVEEPSQRATTISTT---TSTTA------------ 168

  Fly   188 QNGIISGSGSDIGGHSTGINSIAAHTPTQTSSTIPTTSTSTPMPTTTPTATTPASTTTA--AATQ 250
                                  |..|...|.:|.|.|:.:| .|:|  .|..||:.|||  ..|.
  Rat   169 ----------------------ATTTGAPTMATAPATAATT-APST--PAAPPATATTADIRTTG 208

  Fly   251 ISSFANSSSTTTTTLAPTIPAEPQQPLFPPFDKDLDTESSGDGIDADAEDDDEDDGDDKDYDYNK 315
            |........||..|...|.||.|..|...   ..||||:....:                  .|.
  Rat   209 IQGLLPLPLTTAATAKATTPAVPSPPTTV---ATLDTEAPTPRL------------------VNT 252

  Fly   316 ELDKEIDIDGPEPGHLPPVVHHNTV----------ETGHIPTTDEIDVDGGDEDDNGDSDIDGPR 370
            ...:...:..|.....|.|...:|:          |....||.:.:.....||.       :.|.
  Rat   253 ATSRPRALPRPVTTQEPEVAERSTLPLGTTAPGPTEVAQTPTPESLLTTTQDEP-------EVPV 310

  Fly   371 IGGNDGDITERGPGAGGSNVHELDPNTNVNSQPSDTKGIDHRPNGNEVVIMSEDDR--------- 426
            .||..||...:.........:|:.......::||...|.  .|.|....:...|:.
  Rat   311 SGGPSGDFELQEETTQPDTANEVVAVEGAAAKPSPPLGT--LPKGARPGLGLHDNAIDSGSSAAQ 373

  Fly   427 --TSSFFSQPGILAAVIGGAVVGLLCAILVVMFIVYRMRKKDEGSYALDEPKRSPANNSYAKNAN 489
              ..|...:..:|.|||.|.|||.|.|..:|..::|||:|||||||.|:|||:  |:.:|.|...
  Rat   374 LPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQ--ASVTYQKPDK 436

  Fly   490 NREFYA 495
            ..||||
  Rat   437 QEEFYA 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdc	NP_001163238.2	Syndecan	429..493	CDD:279386	29/63 (46%)
Sdc3	NP_446345.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..85		13/30 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..175		10/60 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..199		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..244		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..327		14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..372		6/34 (18%)
		Syndecan	<399..440	CDD:279386	19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..442		10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335892
Domainoid	1	1.000	62	1.000	Domainoid score	I10057
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5153
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44696
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10915
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6774
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.080