DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and Acox2

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001155139.1	Gene:	Acox2 / 93732	MGIID:	1934852	Length:	681	Species:	Mus musculus

Alignment Length:	678	Identity:	240/678 - (35%)
Similarity:	366/678 - (53%)	Gaps:	33/678 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFSDLEDGYGLNHEY-MSHEEVYNST 75
            |:||:..||.:..|.||..:....||....:.:|.:|..|..|  ..:.|.|.| |:.:|:|...
Mouse    18 VHPDIDSERHSPSFSVERLTNILDGGIPNTELRRRVESLIQRD--PVFNLKHLYFMTRDELYEDA 80

  Fly    76 VKKVAEAAVKLKALQNKLNPGGTDIWPGGLFNAQSF-GLFPAN-HPIATHITMFVDVIKGQGTAE 138
            |:|    ...|:.|...|  |.::..|..::..:.. |....| |.||      ::.|:..|:.|
Mouse    81 VQK----RFHLEKLAWSL--GWSEDGPERIYADRVLAGYNNLNLHGIA------MNAIRSLGSDE 133

  Fly   139 QVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNTPNLEAYKWWPGGLGHT 203
            |:.|||:..:|..||.|||||||.|||.::||.|.|.:|..|.|||:::|.:.:.|||||.||.|
Mouse   134 QIAKWGQLGKNFQIITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRT 198

  Fly   204 ANHAMVVAQLYIADVHHGVQMFIVPLRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNHVRIP 268
            ..||:|:|.|......||:..||||:|..|.|.||||:.:|:||.|:|..:::.|||.|||||:|
Mouse   199 VTHAVVLAHLICLGARHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVP 263

  Fly   269 RTNMLMKFAKVERDGTFKASPASRINYLTMVYTRC-LIVSQNSTLLLAAATIATRYSAVRRQSPI 332
            |.|||.:||:|..|||::.....:.|||.|:.||. |:.......|..|.|||.||:.:|.||.:
Mouse   264 RENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRYAVIRHQSRL 328

  Fly   333 EPNQPEPQIIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQTVQEANNGKFERLPDMHILSCAL 397
            .|:.||.:|:::.||:.||.|::|...|.|..|..:.:.:..:..:.....|..||::|.||..:
Mouse   329 RPSDPEAKILEYQTQQQKLLPQLAVSYALHFMTTSLLQFFHSSYSDILKRDFSLLPELHALSTGM 393

  Fly   398 KVLCTTDGCA-GIEKLRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAW-- 459
            |.: ::|.|| |.|..|.:.|||||...:.|..:...|:|:.|||||||||.||:.|.|:|::
Mouse   394 KAM-SSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQVARFLMKSYLQ 457

  Fly   460 ----ASFVDKKPLSASYSYFASSMQLKEFPKWDDSWQC---IIKALQYTAAHKTRIAFENLANRM 517
                ...:.:|||..|..|.|:....:...:....::|   ...|..|.:|...|.|.::....|
Mouse   458 AQVSPGSIPQKPLPQSVMYLATPRPARCPAQTAADFRCPEVYTTAWAYVSARLIRDATQHTQTLM 522

  Fly   518 ASGQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQITGAKAQKRSPALNKILENVLELFLVQTV 582
            .||..|..|.|.|.:...:||:.|......:.|.|.:   :.....|.:.::|:|:.:|:.:..:
Mouse   523 RSGVDQYDAWNQTSVIHLQAAKAHCYFLTVRNFKEAV---EKLDNEPEIQRVLQNLCDLYALNGI 584

  Fly   583 LNNLNDILRFIKLSDADLRSLQKRLEDSLAQFRPNAVAICDGFEFHDRVLNSVLGSYDGNVYPRL 647
            |.|..|.|....||.|.:...:....|.|...|.:|:.:.|.|:|.|..|||.||.|||:||.||
Mouse   585 LTNSGDFLHDGFLSGAQVDMARTAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYQRL 649

  Fly   648 FDSAKRSTMNQKPVQTSFETYLKPLMKA 675
            |:.|::|..|.:. ..:::.|::|||::
Mouse   650 FEWAQKSPANTQE-NPAYKKYIRPLMQS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	233/652 (36%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	237/674 (35%)
Acox2	NP_001155139.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/9 (56%)
		AXO	20..655	CDD:173839	233/652 (36%)
		Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845539
Domainoid	1	1.000	151	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2317
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.710