DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and POX1

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_011310.1	Gene:	POX1 / 852667	SGDID:	S000003173	Length:	748	Species:	Saccharomyces cerevisiae

Alignment Length:	763	Identity:	204/763 - (26%)
Similarity:	331/763 - (43%)	Gaps:	142/763 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STVNPD---------LQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFSDL---------E 56
            :|:|||         :|||||.::..|::.:.:.....:    :|.:..|:...:         .
Yeast     5 TTINPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPE----RRTLTHALIDQIVNDPILKTDT 65

  Fly    57 DGYGLNHEYMSHEEVYNSTVKKVAEAA------VK-----------LKALQ----NKLNPGGTDI 100
            |.|  :.:.|...|:   |.||:|..|      :|           :|.||    :|.:|
Yeast    66 DYY--DAKKMQEREI---TAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASP----- 120

  Fly   101 WPGGLFNAQSF------GLFPANHP-----IATHITMFVDVIKGQGTAEQVEKWGK---AAENCN 151
                |.|...|      .|.....|     :..|:.:|.:.|||.||.||:..|.:   |.....
Yeast   121 ----LTNKDLFIFDKRLSLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKG 181

  Fly   152 IIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNTPNLEAYKWWPGGLGHTANHAMVVAQLYIA 216
            |.|.:|.|||.||:||..|.|||.:|.:.|.||::||:|.|.|||.||..|:|.||.|.|:|.:.
Yeast   182 IYGCFAMTELGHGSNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVE 246

  Fly   217 DVHHGVQMFIVPLRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNHVRIPRTNMLMKFAKVER 281
            ...:||:.|:|||||..|...|.||.||:||.|:|...::.|::...:|.|||..||.:|.||.|
Yeast   247 GKDYGVKTFVVPLRDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVR 311

  Fly   282 --DG--TFKASP-ASRIN-YLTMVYTRCLIVSQNSTLLLAAATIATRYSAVRRQSPIEPNQPEPQ 340
              ||  |.|..| ..:|: |..::..|..:|..:.......||||.||:..|:|........|.|
Yeast   312 SPDGSVTVKTEPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQ 376

  Fly   341 IIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQTVQEANNGK-----------FERLPDMHILS 394
            :||:...:.::.|::............:.:.|..|:.|..|..           .::|.::.|.|
Yeast   377 LIDYPLHQYRVLPQLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDS 441

  Fly   395 CALKVLCTTDGCAGIEKLRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAW 459
            .:||...|......|::||.:.|||||.........|.:.|...|:||:|.||.|...::::|
Yeast   442 ASLKATNTWLIATLIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILK-- 504

  Fly   460 ASFVDKKPL----------SASY---SYFASSMQ------LKEFPKWDDSWQ-CIIKALQY--TA 502
             .|:|....          |.||   .|..|.:.      |||...:.:.|. .:||.|.:  |.
Yeast   505 -KFIDSATKGRFDNTLDVDSFSYLKPQYIGSVVSGEIKSGLKELGDYTEIWSITLIKLLAHIGTL 568

  Fly   503 AHKTRIAFENLANRMASGQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQITGAKAQKRSPALN 567
            ..|:|                  :.::....|...::.|..:.:.:|:.:::....:........
Yeast   569 VEKSR------------------SIDSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITK 615

  Fly   568 KILENVLELFLVQTVLNNLNDILRF-IKLSDADLRSLQKRLEDSLAQFRPNAVAICDGFEFHDRV 631
            :.:.||.:||.:..:..:..:..:| |...|...:.:|.:|...|...|.:.:.:.|.||..|.:
Yeast   616 ESMWNVYKLFSLYFIDKHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAM 680

  Fly   632 LNSVLGSYDGNVYPRLFDSAKRSTMNQKPVQT------SFETYLKPLM 673
            |||.:|.:||::|...|:...|:    .||:.      |:...|..::
Yeast   681 LNSPIGYFDGDIYHNYFNEVCRN----NPVEADGAGKPSYHALLSSML 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	197/731 (27%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	200/748 (27%)
POX1	NP_011310.1	AXO	18..702	CDD:173839	195/722 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I1299
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
TreeFam	0	0.000	Not matched by this tool.
	7	6.720