DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and ACOX3

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001362712.1	Gene:	ACOX3 / 8310	HGNCID:	121	Length:	700	Species:	Homo sapiens

Alignment Length:	714	Identity:	186/714 - (26%)
Similarity:	308/714 - (43%)	Gaps:	130/714 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIPSTVNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFSD------------LEDGY 59
            |:|......|...||.|.|..:|. |.:..|:..|:.|:.|..|:.:|            ||...
Human    12 LLPEFPRGPLDAYRARASFSWKEL-ALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYR 75

  Fly    60 GLN---------HEYMSHEEVYNSTVKKVAEAAVKLKALQNKLNPGGTDIWPGGLFNAQSFGLFP 115
            .||         ::::|.|:::.|        .:|:.||...|....:.:....|.::..||...
Human    76 ELNFLRCKRIFEYDFLSVEDMFKS--------PLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAV 132

  Fly   116 ANHPIATHITMFVDVIKGQGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKT 180
            .:.....|:|....:.:                 ..|.|.:|.|||:||:|.:.:.|.|.:||.|
Human   133 YSSGSERHLTYIQKIFR-----------------MEIFGCFALTELSHGSNTKAIRTTAHYDPAT 180

  Fly   181 DEFVLNTPNLEAYKWWPGGLGHTANHAMVVAQLYI-ADVHHGVQMFIVPLRDSETHMPLPGVDIG 244
            :||::::|:.||.|:|.|.:|.||.||:|.|:|.: .|..||:..|||.:||.:|.:|:|||.:|
Human   181 EEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVG 245

  Fly   245 EIGKKLGMASVNQGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRINYL------TMVYTRC 303
            :||||||...::.||...:.||:||.::|.:...|..:||: .||...:...      ::...|.
Human   246 DIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTY-VSPFKDVRQRFGASLGSLSSGRV 309

  Fly   304 LIVSQNSTLLLAAATIATRYSAVRRQ-SPIEPNQPEPQIIDHVTQRLKLFPEIATGIAY-HLATE 366
            .|||.....|..|..||.|:||.||| .|.|  :.|..::::..|:.:|.|.:|...|. |.:..
Human   310 SIVSLAILNLKLAVAIALRFSATRRQFGPTE--EEEIPVLEYPMQQWRLLPYLAAVYALDHFSKS 372

  Fly   367 YMWEMYA---------QTVQEANNGKFERLPDMHILSCALKVLCTTDGCAGIEKLRLSTGGHGYL 422
            ...::..         ::.::|..|:     ::|.|:.|.|.|.:.....||::.|.:.||||||
Human   373 LFLDLVELQRGLASGDRSARQAELGR-----EIHALASASKPLASWTTQQGIQECREACGGHGYL 432

  Fly   423 IAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAWA----------------SFVDKKPLSAS 471
            ....|..:..:.....||||:|.:||.|....|:...|                .|:|..|....
Human   433 AMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILD 497

  Fly   472 YSYFASSMQLKEFPKWDDSWQCI-----IKALQYTAAHKTRIAFENLANRMASGQSQGVAANNTG 531
            ..:..||:.           .|:     :.|.::...:..|..::.|.....||.|...|.|...
Human   498 QKFEVSSVA-----------DCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQ 551

  Fly   532 IELTRAAELHGRQF--------VCQTFLEQITGAKAQKRSPALNKILENVLELFLVQTVLNNLND 588
            :.       |||..        |.|.|.|.:.....   .|:|..:|..:..|:.:.::..:...
Human   552 VS-------HGRPLALAFVELTVVQRFHEHVHQPSV---PPSLRAVLGRLSALYALWSLSRHAAL 606

  Fly   589 ILRFIKLSDADLRSLQKRLEDSL----AQFRPNAVAICDGFEFHDRVLNSVLGSYDGNVYPRLF 648
            :.|....|......:   ||.::    :|.:.:|||:.|.....|.||:|.:|..||.:|..|:
Human   607 LYRGGYFSGEQAGEV---LESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLW 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	184/707 (26%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	184/705 (26%)
ACOX3	NP_001362712.1	AXO	19..672	CDD:173839	184/707 (26%)
ACOX3	NP_001362712.1	Microbody targeting signal. /evidence=ECO:0000250\|UniProtKB:Q63448	698..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810