DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and ACOX2

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_003491.1	Gene:	ACOX2 / 8309	HGNCID:	120	Length:	681	Species:	Homo sapiens

Alignment Length:	688	Identity:	231/688 - (33%)
Similarity:	361/688 - (52%)	Gaps:	53/688 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFS----DLEDGYGLNHEYMSHEEVY 72
            ::||::.||....|.||..:....||......:|::|..|.|    ..:|.|     :|:..|.|
Human    18 MHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEFSCKDNY-----FMTQNERY 77

  Fly    73 NSTVKKVAEAAVKLKALQNKLNPGGTDIWPGGLFNAQSFGLF--PANHPIATHI-TMFVDVIKGQ 134
            .:.:::    |..::.:..:|         |.|.:.:..|..  ..:..:|.:| .:||..::..
Human    78 KAAMRR----AFHIRLIARRL---------GWLEDGRELGYAYRALSGDVALNIHRVFVRALRSL 129

  Fly   135 GTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNTPNLEAYKWWPGG 199
            |:.||:.||....:|..||.|||||||.|||.::||.|.|.:|..|.|||:::|.|.|.|||||.
Human   130 GSEEQIAKWDPLCKNIQIIATYAQTELGHGTYLQGLETEATYDAATQEFVIHSPTLTATKWWPGD 194

  Fly   200 LGHTANHAMVVAQLYIADVHHGVQMFIVPLRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNH 264
            ||.:|.||:|.|||..:....|:..||||:|..:.|.||||:.||:||.|:.....:.|||.|||
Human   195 LGRSATHALVQAQLICSGARRGMHAFIVPIRSLQDHTPLPGIIIGDIGPKMDFDQTDNGFLQLNH 259

  Fly   265 VRIPRTNMLMKFAKVERDGTFKASPASRINYLTMVYTRC-LIVSQNSTLLLAAATIATRYSAVRR 328
            ||:||.|||.:||:|..|||:.....::.|||.||..|. |:..:...:|..|..||.|||.:||
Human   260 VRVPRENMLSRFAQVLPDGTYVKLGTAQSNYLPMVVVRVELLSGEILPILQKACVIAMRYSVIRR 324

  Fly   329 QSPIEPNQPEPQIIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQTVQEANNGKFERLPDMHIL 393
            ||.:.|:.||.:::|:.||:.||||::|...|:|.....:.|.:..:.....|..|..||::|.|
Human   325 QSRLRPSDPEAKVLDYQTQQQKLFPQLAISYAFHFLAVSLLEFFQHSYTAILNQDFSFLPELHAL 389

  Fly   394 SCALKVLCTTDGCAGIEKLRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKA 458
            |..:|.:.:.....|.|..|.:.|||||...:.|.::.....|:.|||||||||.||:.|.|||:
Human   390 STGMKAMMSEFCTQGAEMCRRACGGHGYSKLSGLPSLVTKLSASCTYEGENTVLYLQVARFLVKS 454

  Fly   459 W------ASFVDKKPLSASYSYFAS-------SMQLKEF--PK-WDDSWQCIIKALQYTAAHKTR 507
            :      .....::.||.|.:|..:       :.:..:|  |: :..:|       .:.|....:
Human   455 YLQTQMSPGSTPQRSLSPSVAYLTAPDLARCPAQRAADFLCPELYTTAW-------AHVAVRLIK 512

  Fly   508 IAFENLANRMASGQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQITGAKAQKRSPALNKILEN 572
            .:.::|.....||..|..|.|.|.:...:||::|......:.|.|.:   :..:..||:.::|:.
Human   513 DSVQHLQTLTQSGADQHEAWNQTTVIHLQAAKVHCYYVTVKGFTEAL---EKLENEPAIQQVLKR 574

  Fly   573 VLELFLVQTVLNNLNDILRFIKLSDADLRSLQKRLEDSLAQFRPNAVAICDGFEFHDRVLNSVLG 637
            :.:|..:..:|.|..|.|....||.|.:...:....|.|...|.:|:.:.|.|:|.|:.|||.||
Human   575 LCDLHAIHGILTNSGDFLHDAFLSGAQVDMARTAYLDLLRLIRKDAILLTDAFDFTDQCLNSALG 639

  Fly   638 SYDGNVYPRLFDSAKRSTMNQKPVQTSFETYLKPLMKA 675
            .||||||.|||..|::|..|.:. ..::|.|::||:::
Human   640 CYDGNVYERLFQWAQKSPTNTQE-NPAYEEYIRPLLQS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	225/662 (34%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	229/684 (33%)
ACOX2	NP_003491.1	ACAD	20..655	CDD:324545	225/662 (34%)
ACOX2	NP_003491.1	Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155076
Domainoid	1	1.000	151	1.000	Domainoid score	I4347
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2317
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm8477
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.710