DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and Acox3

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_006504259.1	Gene:	Acox3 / 80911	MGIID:	1933156	Length:	755	Species:	Mus musculus

Alignment Length:	699	Identity:	195/699 - (27%)
Similarity:	318/699 - (45%)	Gaps:	128/699 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQKERAAAEFHVEEFSAWWHGGQDKLKKKREIEKAIFSDLED------GYG----------LNHE 64
            |...||.|.|:..|...:| .|||.:    ..:|.|||.||:      .||          ||
Mouse    21 LSAYRARASFNSGELLLFW-DGQDVI----HFKKTIFSTLENDPLFARSYGADLPLEKLRELN-- 78

  Fly    65 YMSHEEVYNSTVKKVAEA---AVKLKALQNKLNPGGTDIWPGGLFNAQSFGLFPAN----HPIAT 122
            ::..:.|:.....||.|.   .:|:..|.|.|          |:::   :.|  ||    |.:..
Mouse    79 FLRCKRVFEYGFFKVEELLKNPLKILVLINCL----------GMYD---WSL--ANKCVLHMLVF 128

  Fly   123 HITMFVDVIKGQGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNT 187
            ..|:||      ..:|:..|:.:...:..|.|.:|.|||:||:|.:.:.|.|.:||.|.||:|::
Mouse   129 GTTVFV------SGSEKHFKYLEKIYSLEIFGCFALTELSHGSNTKAMRTTAHYDPDTQEFILHS 187

  Fly   188 PNLEAYKWWPGGLGHTANHAMVVAQLYIADVH-HGVQMFIVPLRDSETHMPLPGVDIGEIGKKLG 251
            |:.||.|:|.|.||.||.||:|.||||:.|.. ||:..|:|.:||::|.:|:.||.:|:||||||
Mouse   188 PDFEAAKFWVGNLGKTATHAVVFAQLYMPDGQCHGLHSFLVQIRDTKTLLPMTGVMVGDIGKKLG 252

  Fly   252 MASVNQGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRINYL------TMVYTRCLIVSQNS 310
            ...::.||...|.|||||.|:|.:...:..:||:. ||...:...      ::...|..|:|.:.
Mouse   253 QNGLDNGFAMFNKVRIPRQNLLDRTGNITSEGTYN-SPFKDVRQRLGASLGSLSSGRISIISMSV 316

  Fly   311 TLLLAAATIATRYSAVRRQ-SPIEPNQPEPQIIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQ 374
            ..|..|.:||.|:||.|.| .|.:  :.|..::::..|:.::.|        :||..|..:.:::
Mouse   317 VNLKLAVSIAIRFSATRCQFGPTD--KEEIPVLEYPLQQWRILP--------YLAAAYALDHFSK 371

  Fly   375 TV------------------QEANNGKFERLPDMHILSCALKVLCTTDGCAGIEKLRLSTGGHGY 421
            |:                  |:|..|:     ::|.|:.|.|.|.:.....||::.|.:.|||||
Mouse   372 TIFMDLIEVQSARLRGDHSDQQAELGR-----EIHALASAGKPLASWTAQRGIQECREACGGHGY 431

  Fly   422 LIAANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAWASFVDKKPLSASYSYFASSMQ----LK 482
            |......::..:.....||||:|.|||.|....|:.     :.:.||... ::|.|.::    |:
Mouse   432 LAMNRFGDLRNDNDPNCTYEGDNNVLLQQTSNYLLS-----LLEPPLQDG-AHFTSPLKTVDFLE 490

  Fly   483 EFP-------------KWDDSWQCIIKALQYTAAHKTRIAFENLANRMASGQSQGVAANNTGIEL 534
            .:|             .|.|| ...:.|.::...:..:.:.........|..|...|.||:.:..
Mouse   491 AYPGILGQKFLGSSKADWMDS-AAPLAAYRWLVCYLLQESHRRYCQEKKSRGSDFEARNNSQVYG 554

  Fly   535 TRAAELHGRQF-VCQTFLEQITGAKAQKRSPALNKILENVLELFLVQTVLNNLNDILRFIKLSDA 598
            .|...|...:. |.|.|.|.|   .:...||:|..:|..:..|:.:..:..::..:.|...:|.
Mouse   555 CRPLALAFMELTVMQRFHEHI---HSSGLSPSLRTVLGRLSTLYGLWCLSQHMALLYRGGYISG- 615

  Fly   599 DLRSLQKRLEDSL----AQFRPNAVAICDGFEFHDRVLNSVLGSYDGNV 643
              ....:.:||::    .|.:.:|||:.|.....|.||||.:...||.|
Mouse   616 --EQTGRAMEDAILTLCEQLKDDAVALVDVIAPSDFVLNSPIAKADGEV 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	195/699 (28%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	195/699 (28%)
Acox3	XP_006504259.1	AXO	19..663	CDD:173839	195/699 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810