DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acox57D-d and GCDH

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_000150.1	Gene:	GCDH / 2639	HGNCID:	4189	Length:	438	Species:	Homo sapiens

Alignment Length:	363	Identity:	73/363 - (20%)
Similarity:	126/363 - (34%)	Gaps:	109/363 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HPIATHITMFVDVIKGQGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDE 182
            |||..:           |:.||.:|:........::|.:..||...|::...:.|||.::.....
Human   150 HPIYAY-----------GSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKS 203

  Fly   183 FVLNTPNLEAYKWWPGGLGHTANHAMVVAQLYI--ADVHHG-VQMFIVPLRDSETHMPLPGVDIG 244
            :.||     ..|.|      ..|..|  |.|::  |....| ::.|::       ...:.|:...
Human   204 YTLN-----GTKTW------ITNSPM--ADLFVVWARCEDGCIRGFLL-------EKGMRGLSAP 248

  Fly   245 EIGKKLGMASVNQGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRINYLTMVYTRCLIVSQN 309
            .|..|..:.:...|.:.::.|.:|..|:|...:.:  .|.|                .||   .|
Human   249 RIQGKFSLRASATGMIIMDGVEVPEENVLPGASSL--GGPF----------------GCL---NN 292

  Fly   310 STLLLAAATI---------ATRYSAVRRQ--SPIEPNQ-PEPQIIDHVTQRLKLFPEIATGIAYH 362
            :...:|...:         |.:|:..|.|  .|:..|| .:.::.|.:|       ||..|:  |
Human   293 ARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLT-------EITLGL--H 348

  Fly   363 LATEYMWEMYAQTVQEANNGKFERLPDMHILSCALKVLCTTDGCAG----IEKLRLSTGGHGYLI 423
            ...:                 ..||.|....:..:..|...:.|..    ..:.|...||:|
Human   349 ACLQ-----------------LGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNG--- 393

  Fly   424 AANLSNIYG------NAVAAYTYEGENTVLLLQIGRAL 455
               :|:.|.      |..|..||||.:.:..|.:|||:
Human   394 ---ISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	73/363 (20%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	73/363 (20%)
GCDH	NP_000150.1	GCD	48..434	CDD:173840	73/363 (20%)
		Substrate binding	138..139
		Substrate binding	287..294		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810