DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and Acadvl

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	146/704 - (20%)
Similarity:	235/704 - (33%)	Gaps:	226/704 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PSTVNPDLQKERAAAEFHVEEFSAWWHGGQ---DKLKKKREIEKAIF---SDLEDGYGLNHEYMS 67
            |.|::.|.......|....:.|:.....||   |:          :|   |.|.:|   ..:::.
  Rat    52 PETLSSDASTREKPARAESKSFAVGMFKGQLTTDQ----------VFPYPSVLNEG---QTQFLK 103

  Fly    68 H---------EEV----YNSTVKKVAEAAVK-LK-----ALQNKLNPGGTDIWPGGLFNAQSFGL 113
            .         |||    .|.:::||.|..:: ||     .||.....||.     ||.|.|...|
  Rat   104 ELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGL-----GLSNTQYARL 163

  Fly   114 --FPANHPIATHITMFVDV---IKG---QGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGL 170
              ....|.:...:|:....   .||   .||..|.||:.....:...:..:..||.:.|::|..:
  Rat   164 AEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASI 228

  Fly   171 ATRADFDPKTDEFVLNTPNLEAYKWW--PGGLGHTANHAMVVAQLYIADVHHG-----VQMFIVP 228
            .:.|...|....:.||     ..|.|  .|||   |:...|.|:..|.|...|     :..|:|
  Rat   229 RSSAVPSPCGKYYTLN-----GSKIWISNGGL---ADIFTVFAKTPIKDAATGAVKEKITAFVV- 284

  Fly   229 LRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRI 293
                  .....||..|...||:|:.:.|...:..:.|::|..|:|.:..    || ||.:    :
  Rat   285 ------ERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVG----DG-FKVA----V 334

  Fly   294 NYLTMVYTRCLIVSQNSTLLLAAATIATRYSAVRRQSPIEPNQPEPQIIDHVTQRLKL------F 352
            |.|            |:.....|||:|....|:..::           :||.|.|.:.      |
  Rat   335 NIL------------NNGRFGMAATLAGTMKAIIAKA-----------VDHATNRTQFGDKIHNF 376

  Fly   353 PEIATGIAYHLATEYMWEMYAQTVQEANNGKFERLPDMHILSCALKVLCT------TDGCAGIEK 411
            ..|...:|.....:|:.|..|..:....:..|:   |..|.:...|:..:      ||.|..|
  Rat   377 GVIQEKLARMAILQYVTESMAYMLSANMDQGFK---DFQIEAAISKIFGSEAAWKVTDECIQI-- 436

  Fly   412 LRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVL---------------LLQIGRALVKAWAS 461
                .||.|::....:..:..:......:||.|.:|               |..:|.||
  Rat   437 ----MGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNAL------ 491

  Fly   462 FVDKKPL-SASYSYFASSMQLKEFPKWDDSWQCIIKALQYTAAHKTRIAFENLANRMASGQSQGV 525
               |.|| :.......:|.||                                  |..:|...|:
  Rat   492 ---KNPLGNVGLLIGEASKQL----------------------------------RRRTGIGSGL 519

  Fly   526 AANNTGI---ELTRAAELHGRQFVCQTFLEQ---ITGAKAQKRSPALNKILENVLELFLVQTVLN 584
            :.  :||   ||:|:.||      ....|||   :..||..|....:      |.|.||:|.:.:
  Rat   520 SL--SGIVHPELSRSGEL------AVQALEQFATVVEAKLMKHKKGI------VNEQFLLQRLAD 570

  Fly   585 NLNDILRFIKLSDADLRSLQK---------------------RLEDSLAQFRPN 617
            ...|:...:.:.....|||.:                     |:.:::|..:.|
  Rat   571 GAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSN 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	144/699 (21%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	143/697 (21%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		4/17 (24%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		108/503 (21%)
		VLCAD	72..481	CDD:173850	104/482 (22%)
		CaiA	100..473	CDD:224871	96/433 (22%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		12/75 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810