DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-d and acox-1.1

DIOPT Version :9

Sequence 1:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001021089.1	Gene:	acox-1.1 / 173162	WormBaseID:	WBGene00008564	Length:	674	Species:	Caenorhabditis elegans

Alignment Length:	702	Identity:	261/702 - (37%)
Similarity:	382/702 - (54%)	Gaps:	63/702 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHIKNLIPSTVNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKREI--EKAIFSDLEDGYGLNH 63
            |.|:...|....||||..||..|.|.....:|..:||:.:.:::|||  :.|...:|.|...|
Worm     1 MVHLNKTIQEGDNPDLTAERLTATFDTHAMAAQIYGGEMRARRRREITAKLAEIPELHDSMPL-- 63

  Fly    64 EYMSHEEVYNSTVKKVAEAAVKLKALQNKLNP--GGTDIWPGGLFNAQSFGLFPANHPIATHITM 126
            .||:.||       |:.|:|.||..|..:::.  ..||  .|.|::..:..|....:|:|.|..|
Worm    64 PYMTREE-------KIMESARKLTVLTQRMSEIIDPTD--AGELYHLNNEVLGIEGNPMALHGVM 119

  Fly   127 FVDVIKGQGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRGLATRADFDPKTDEFVLNTPNLE 191
            |:..:..|.:.||..||...|....|||||||||:.||||::.|.|.|.:|..|.||||:||.:.
Worm   120 FIPALNAQASDEQQAKWLIRALRREIIGTYAQTEMGHGTNLQNLETTATYDIGTQEFVLHTPKIT 184

  Fly   192 AYKWWPGGLGHTANHAMVVAQLYIADVHHGVQMFIVPLRDSETHMPLPGVDIGEIGKKLGMASVN 256
            |.|||||.||.::|:|:|||.:||...:.|...|:|||||.:||.||||:.||:||.|:....|:
Worm   185 ALKWWPGNLGKSSNYAVVVAHMYIKGKNFGPHTFMVPLRDEKTHKPLPGITIGDIGPKMAYNIVD 249

  Fly   257 QGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRINYLTMVYTRCLIVSQNSTLLLAAATIAT 321
            .||||.|:.||||||:||:..|||.|||:...|.::|||..||:.|..:::..:.:|..|..|||
Worm   250 NGFLGFNNYRIPRTNLLMRHTKVEADGTYIKPPHAKINYSAMVHVRSYMLTGQAIMLSYALNIAT 314

  Fly   322 RYSAVRRQSPIEPNQPEPQIIDHVTQRLKLFPEIATGIAYHLATEYMWEMYAQTVQEANNGKFER 386
            ||||||||..|:.|:||.:::::.||:.:|||.||...|:..|.....::|.:.::|..:|....
Worm   315 RYSAVRRQGQIDKNEPEVKVLEYQTQQHRLFPFIARAYAFQFAGAETVKLYERVLKEMKSGNVSL 379

  Fly   387 LPDMHILSCALKVLCTTDGCAGIEKLRLSTGGHGYLIAANLSNIYGNAVAAYTYEGENTVLLLQI 451
            :.|:|.|:..||.:.|.....|||:.|::.|||||.:|:.:|.|||.|:...||||||.|:|||:
Worm   380 MADLHALTSGLKSVVTHQTGEGIEQARMACGGHGYSMASYISEIYGVAIGGCTYEGENMVMLLQL 444

  Fly   452 GRALVKAWA------------------------SFVDKKPLSASYSYFASSMQLKEFPKWDDSWQ 492
            .|.|||:.|                        |.:|:.|......|
Worm   445 ARYLVKSAALVKSGKASQLGPLVAYLGARSEPTSLIDRVPNGGITEY------------------ 491

  Fly   493 CIIKALQYTAAHKTRIAFENLANRMASGQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQITGA 557
              ||..|:.|..:|..|.......|.:|:.:.:|.|.:.:||.||:.||.|.|:.:.|..::.
Worm   492 --IKTFQHIAKRQTLKAANKFFGLMENGEKREIAWNKSSVELNRASRLHTRLFIVEAFARRVN-- 552

  Fly   558 KAQKRSPALNKILENVLELFLVQTVLNNLNDILRFIKLSDADLRSLQKRLEDSLAQFRPNAVAIC 622
              :.....:.:.|.::|.|.:...:|:.....|....:|...|..::.:|...|.:.|||||::.
Worm   553 --EIGDITIKEALSDLLHLHVNYELLDVATYALEDGFMSSTQLDYVRDQLYFYLQKIRPNAVSLL 615

  Fly   623 DGFEFHDRVLNSVLGSYDGNVYPRLFDSAKRSTMNQKPVQTSFETYLKPLMK 674
            |.:||.||.|.||||..||:||..||..||.|.:|:..|..|.:|||||:|:
Worm   616 DSWEFSDRELRSVLGRRDGHVYENLFKWAKESPLNKTDVLPSVDTYLKPMME 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	246/666 (37%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	255/687 (37%)
acox-1.1	NP_001021089.1	ACAD	14..645	CDD:299127	245/665 (37%)
acox-1.1	NP_001021089.1	PLN02443	16..674	CDD:178062	255/687 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163704
Domainoid	1	1.000	206	1.000	Domainoid score	I1698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I803
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm4727
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910