DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acox57D-p and acox3

DIOPT Version :9

Sequence 1:	NP_001286677.1	Gene:	Acox57D-p / 37445	FlyBaseID:	FBgn0034628	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_998312.1	Gene:	acox3 / 406421	ZFINID:	ZDB-GENE-040426-2163	Length:	692	Species:	Danio rerio

Alignment Length:	720	Identity:	210/720 - (29%)
Similarity:	327/720 - (45%)	Gaps:	107/720 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IPTTVNPDLQKERDAASFNSEEFAAWWAGGEEVLKFNRGVREYME----------KDVDLSEMLQ 62
            ||...|..|...|..|||:.::... :..|:|::.|.:.|...:|          :||.:.:..:
Zfish     5 IPDFPNGPLDIYRKKASFSWKDMMR-FLEGDELIAFKQHVFRTLESDPLFARQPGEDVPVEQKRE 68

  Fly    63 LQNKTHEEII--EFSTRGAIEGAKKLRRLQEE--RNPGGDVYWP--------NLYDAQVMWGLVP 115
            |.....:::.  :|.||             ||  :||     |.        .:||    |.|..
Zfish    69 LTFLRCKQLFKYDFITR-------------EELMQNP-----WKMTVLNDCLGMYD----WSLCA 111

  Fly   116 ----GGNPFGVMYVMLVKALQAQCTPEQYEEFGKRVELFEICGTYAQTELGHGTYLRGLETRADF 176
                ....||...|        ....:::.:|.|.:|.....|.::.|||.||:..|.|.|.|.:
Zfish   112 KYFLNKGMFGATVV--------NTGSQRHLKFVKDIERMMTFGCFSLTELSHGSNTRALRTTAKY 168

  Fly   177 DRKTDQFVLNTPNISSYKWWPGGLGHSSNHCLVMAQLYI-DGDCKGPHMFFIQVRDEDTHEPLPG 240
            |..|.:||:|:|:..:.|:|.|.||.::.|.:|.||||. ||.|.|.|.|.:||||..|...:||
Zfish   169 DPNTQEFVINSPDFEAAKFWVGNLGKTATHSVVFAQLYTPDGKCHGLHSFIVQVRDPKTLLAMPG 233

  Fly   241 VHIGDIGKKMGFIGVNNGFLGLKNVRIPRTRMLMRHAQVKADGSYVSSPTNVLTYF-----AMVR 300
            |.:||:|||:|..|::|||....||||||..:|.:...|..||.|||...:....|     |:..
Zfish   234 VMVGDMGKKLGQNGLDNGFAVFHNVRIPRENLLNKTGDVAPDGQYVSPFKDPNKRFGASLGALSG 298

  Fly   301 TRCVIAKNNAVMLASAATIATRYSAVRRQSPINPNE-REPQIMDHVTQQMKLFPEIATSVA---Y 361
            .|..|.:...|.|..|.|:|.|:||.|||  ..|.| .|..::::..||.:|.|.:|...|   :
Zfish   299 GRVGITRMALVNLKLAVTVAVRFSATRRQ--FGPKEDEEIPVLEYQLQQWRLIPFLAAVYALEHF 361

  Fly   362 RKAGDYLWNLYDVTIEDIENGKYERLPEL----HSLSCALKVTCSMDSASGVEKLRLACGGHGFL 422
            .|:  :..|..:..:..:...|.:|..||    |:||||.|...|..:..|:::.|.||||||:|
Zfish   362 TKS--FSMNFVEFQMGLLMKDKSDRQAELGREIHALSCASKPLGSWTAQRGIQECREACGGHGYL 424

  Fly   423 TSSNMSSIYVSATAACTYEGENTVLLLQIGRFLMKTWRAALTG-----APLPPTVRYLAEVQKNP 482
            ..:.:..:.......|||||:|.|||.|...:|:...:....|     :|| .||.:|.::....
Zfish   425 AMNRLGDMRDDNDPNCTYEGDNNVLLQQTSNYLLSWIQHKQEGKGRIESPL-ETVNFLDDMSSIL 488

  Fly   483 EFGTWTGSWENMVKAMQYAAANRTQLAF------RSLSKRMSRGETEANAANHTGIEFTQAAELH 541
            :.....||.|..:.:....||.:..:.|      :.|.:..|.|..:..|.|::.:.:.::..:
Zfish   489 QSKFTVGSVEECMNSAVPLAAYKWLVCFLLGESQKKLFEEKSSGLGDFEARNNSQVYYCRSLAI- 552

  Fly   542 GRAF----VFSAFYEAVTGPQSKTRSANFNRVLENLLELYLVKETLNQMGHLLR---FINLTDTD 599
              ||    |...|::.:   |.:...|....||..|..||.:....|.|..|.:   |......|
Zfish   553 --AFIEHTVLQRFHDLI---QDEQTPAVLRSVLGRLCALYGLWTLTNHMAILYQGGYFSGGQPVD 612

  Fly   600 LSGLQDRLETVLTKLRPDAVAIVDGFDFSDLQLNSTLGSYDGNAYERIFDAAL--KNPMNQKAVP 662
            .  :|..:.|:..:|:.||||:||.|...|..|||.:|..||..|:.::...:  ||.:.:   |
Zfish   613 F--IQTAILTLCGQLKDDAVALVDVFAPPDFILNSPIGKSDGELYKNLWSTVMQGKNVLER---P 672

  Fly   663 KYFHE 667
            .::.|
Zfish   673 SWWAE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-p	NP_001286677.1	ACAD	14..653	CDD:299127	203/698 (29%)
Acox57D-p	NP_001286677.1	PLN02443	16..677	CDD:178062	207/712 (29%)
acox3	NP_998312.1	AXO	11..664	CDD:173839	203/696 (29%)
acox3	NP_998312.1	PLN02312	19..662	CDD:215178	201/686 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810