DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acox57D-p and Acadvl

DIOPT Version :9

Sequence 1:	NP_001286677.1	Gene:	Acox57D-p / 37445	FlyBaseID:	FBgn0034628	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	123/644 - (19%)
Similarity:	207/644 - (32%)	Gaps:	168/644 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PTTVNPDLQKERDAASFNSEEFAAWWAGG----EEVLKF----NRGVREYMEKDVDLSEMLQLQN 65
            |.|::.|.......|...|:.||.....|    ::|..:    |.|..::      |.|::....
  Rat    52 PETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQF------LKELVGPVA 110

  Fly    66 KTHEEI--------IEFSTRGAIEGAKKLRR--LQEERNPGG----DVYWPNLYDAQVMWGLVPG 116
            :..||:        :|......::|.|:|..  ||.....||    :..:..|.:       :.|
  Rat   111 RFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAE-------IVG 168

  Fly   117 GNPFGVMYVMLV------KALQAQCTPEQYEEFGKRVELFEICGTYAQTELGHGTYLRGLETRAD 175
            .:..||...:..      |.:....|..|.|::..||...:....:..||...|:.:..:.:.|.
  Rat   169 MHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAV 233

  Fly   176 FDRKTDQFVLNTPNISSYKWW--PGGLGHSSNHCLVMAQLYIDGDCKGPHMFFIQVRDEDT---- 234
            .......:.||...|     |  .|||   ::...|.|:..|.....|      .|:::.|
  Rat   234 PSPCGKYYTLNGSKI-----WISNGGL---ADIFTVFAKTPIKDAATG------AVKEKITAFVV 284

  Fly   235 HEPLPGVHIGDIGKKMGFIGVNNGFLGLKNVRIPRTRMLMRHAQVKADGSYVSSPTNVLTYFAMV 299
            .....||..|...||||....|...:....|::|...:|   .:| .||..|:  .|:|
  Rat   285 ERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVL---GEV-GDGFKVA--VNIL------ 337

  Fly   300 RTRCVIAKNNAVMLASAATIATRYSAVRRQSPINPNEREPQIMDHVTQ----------------- 347
                    ||. ....|||:|....|:..::           :||.|.
  Rat   338 --------NNG-RFGMAATLAGTMKAIIAKA-----------VDHATNRTQFGDKIHNFGVIQEK 382

  Fly   348 --QMKLFPEIATSVAYRKAGDYLWNLYDVTIEDIENGKYERLPELHSLSCALKVTCSMDSASGVE 410
              :|.:...:..|:||..:.:......|..||       ..:.::.....|.|||         :
  Rat   383 LARMAILQYVTESMAYMLSANMDQGFKDFQIE-------AAISKIFGSEAAWKVT---------D 431

  Fly   411 KLRLACGGHGFLTSSNMSSIYVSATAACTYEGENTVLLLQIGRFLMKTWRAALTGAPLPPTVRYL 475
            :.....||.||:....:..:.........:||.|.:|.|.:...........|||         |
  Rat   432 ECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTG---------L 487

  Fly   476 AEVQKNPEFGTWTGSWENMVKAMQYAAANRTQLAFRSLSKRMSRGETEANAANHTGI---EFTQA 537
            ....|||                    .....|.....||::.|.....:..:.:||   |.:::
  Rat   488 GNALKNP--------------------LGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRS 532

  Fly   538 AELHGRAFVFSAFYEAVTGPQSKTRSANFN------RVLENLLELYLVKETLNQMGHLL 590
            .||..:|  ...|...|.....|.:....|      |:.:..::||.:...|::....|
  Rat   533 GELAVQA--LEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acox57D-p	NP_001286677.1	ACAD	14..653	CDD:299127	121/639 (19%)
Acox57D-p	NP_001286677.1	PLN02443	16..677	CDD:178062	120/637 (19%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		4/17 (24%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		97/504 (19%)
		VLCAD	72..481	CDD:173850	92/483 (19%)
		CaiA	100..473	CDD:224871	86/447 (19%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		11/61 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810