DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEFSec and eefsec

DIOPT Version :9

Sequence 1:	NP_611584.1	Gene:	eEFSec / 37444	FlyBaseID:	FBgn0034627	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001032513.1	Gene:	eefsec / 641497	ZFINID:	ZDB-GENE-051120-72	Length:	576	Species:	Danio rerio

Alignment Length:	569	Identity:	260/569 - (45%)
Similarity:	351/569 - (61%)	Gaps:	61/569 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 INFNIGLLGHVDSGKTTLAKALSSISSTAAFDKNPQSVERGITLDLGFSGLLVDAPAHL------ 61
            :|||:|:|||||||||:||:||||.:|||||||||||.|||||||||||...|..|.||
Zfish     8 LNFNVGVLGHVDSGKTSLARALSSTASTAAFDKNPQSKERGITLDLGFSAFTVPLPEHLRESCGE 72

  Fly    62 PQGEQLQFTFVDCPGHASLIRTIIGGAQIIDLMLLVVDAQKGKQTQTAECLIIGELLQKKLIVVI 126
            .|.:.||||.|||||||||||||||||||||||:||||..||.||||||||:||:|...:::|::
Zfish    73 KQYDSLQFTLVDCPGHASLIRTIIGGAQIIDLMMLVVDVVKGMQTQTAECLLIGQLTCSRMVVIL 137

  Fly   127 NKIDVYPENQRASKLEKLRLRLAKTLEATTFGGQVPICAVSALQG----------THIAELREVL 181
            ||.|:.|.::|.:.::|:..|:.||||.|.| ...||.||:|..|          ..|.||.::|
Zfish   138 NKTDLLPSDKRQAAIDKMTKRMHKTLENTRF-KDCPIIAVAAKPGGPEAPDTDEPQGITELIDLL 201

  Fly   182 REAYFQPQRNLADPLFMYVDHCFGIKGQGTVCTGTLLQGKVQVNNVIELPALGEQRKVKSIQMFR 246
            :...|.|.|:.:..|.|.|||||.|:|||||.|||:|||.:.||:.:|:|||...|||||:||||
Zfish   202 KAQSFLPHRDPSGSLLMAVDHCFSIRGQGTVITGTILQGSLSVNDNVEIPALKVTRKVKSVQMFR 266

  Fly   247 KNVTSASMGDRIGLCVTQFNAKLLERGIITQPGYLKPIYAVCLQFKPIRYYKEVIKSMRKMHISV 311
            |.|.||..|||:|:|||||:.||||||::..||.|:.:||..:..:.|.||:..:.|..|.||:|
Zfish   267 KPVASAMQGDRVGVCVTQFDPKLLERGVVCTPGSLQTLYAAIISVQKIEYYRGALNSRAKFHITV 331

  Fly   312 GHNTVMANVTLFR---------DTDGTT-----STFQLDKEYEYMEDVQPAEVQ---HNDVIYAL 359
            ||.||||.::.|.         |:..|:     ::|..|.|:.::::...::.:   .....:||
Zfish   332 GHETVMARISFFNRVLPANENGDSKPTSQEQSANSFSFDWEFHHLDEHLTSQAEGGKGEPQQWAL 396

  Fly   360 LQFESPVLSPPHSTLIASKLDMDVHSTSCRLAFWGRIAWQTHSSKYFQEELPKLRIFKRKQKVGS 424
            |:||.||..||...:|.|:||.|:|..:|||||.|::........|.:..||:|:|.|.|||.|:
Zfish   397 LEFERPVTCPPLCLVIGSRLDSDIHGNTCRLAFHGKLLEGFEDKNYTETALPRLKISKDKQKEGA 461

  Fly   425 IQRVVNSSEVIVQNLF-KDAKRDLYVGKNVELSTGEKGRIERTFGQTSKVAITFQDALSPETIS- 487
            ::||.:...||.:||| |:....|:||..|.|||||.|.||..|||:.|:.|...:.|..||..
Zfish   462 VERVTDDYTVIGRNLFKKETNLQLFVGLKVTLSTGEAGSIEGGFGQSGKIKIRIPEGLKEETKQL 526

  Fly   488 -------------------------NVKNVKVLLNCKKYVFNKQAGLFQ 511
                                     :.:.|.:.||.|:|:::....:.|
Zfish   527 LSSSSKKKGKGGSKNESPKLEEAKPDAQPVTIHLNFKRYIYDPHKKMVQ 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEFSec	NP_611584.1	SelB_euk	5..192	CDD:206676	116/202 (57%)
		SelB	6..467	CDD:225815	244/494 (49%)
		SelB_II	196..278	CDD:293897	53/81 (65%)
		eSelB_III	283..396	CDD:294009	43/129 (33%)
eefsec	NP_001032513.1	SelB_euk	10..202	CDD:206676	112/192 (58%)
		GTP_EFTU	11..201	CDD:278438	111/190 (58%)
		SelB_II	216..298	CDD:293897	53/81 (65%)
		eSelB_III	303..433	CDD:294009	43/129 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593386
Domainoid	1	1.000	207	1.000	Domainoid score	I2847
eggNOG	1	0.900	-	-		E1_COG3276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11073
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1524
OMA	1	1.010	-	-		QHG55121
OrthoDB	1	1.010	-	-		D370293at33208
OrthoFinder	1	1.000	-	-		FOG0007177
OrthoInspector	1	1.000	-	-		oto39294
orthoMCL	1	0.900	-	-		OOG6_103847
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3582
SonicParanoid	1	1.000	-	-		X5287
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800