DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEFSec and waw

DIOPT Version :9

Sequence 1:	NP_611584.1	Gene:	eEFSec / 37444	FlyBaseID:	FBgn0034627	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001027089.1	Gene:	waw / 3771960	FlyBaseID:	FBgn0024182	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	127/548 - (23%)
Similarity:	213/548 - (38%)	Gaps:	141/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPI----NFNIGLLGHVDSGKTTLAKALSSISSTAAFDKNPQSV--------ERGITLDLGFSGL 53
            ||:    ||:|  :.|||.||:|||..|..::...|.:.....|        |||||:....:.:
  Fly    94 MPVERIRNFSI--IAHVDHGKSTLADRLLELTGAIARNGGQHQVLDNLQVERERGITVKAQTASI 156

  Fly    54 LVDAPAHLPQGEQLQFTFVDCPGHASLIRTIIGGAQIIDLMLLVVDAQKGKQTQTAECLIIGELL 118
            .     |..:|:......:|.|||......:.......|.::|:|||..|.|.||.....:.:..
  Fly   157 F-----HRHKGQLYLLNLIDTPGHVDFSNEVSRSLAACDGVVLLVDACHGVQAQTVANYHLAKQR 216

  Fly   119 QKKLIVVINKIDVYPEN--QRASKLEKLRLRLAKTLEATTFG-GQVPICAVSALQGTHIAELREV 180
            |..::.|:||||:...|  |....|:.|            || ....:..|||..||.::|:.|.
  Fly   217 QLAVVPVLNKIDIKHANPDQVCQDLKLL------------FGIDPDEVLRVSAKLGTGVSEVLER 269

  Fly   181 LREAYFQPQ-RNLADPLFMYVDHCFGIKGQGTVCTGTLLQGKVQVNNVIELPALGEQRKVKSIQM 244
            :.|....|| :..:|...:..|..|. |.:|.:....:|.||::.|..|:..|..:...||||.:
  Fly   270 VIETVPPPQVQRDSDFRALIFDSWFD-KYRGALNLIYVLNGKLEQNQDIQSLATKKVYSVKSISV 333

  Fly   245 FRK---NVTSASMGDRIGLCVTQFNAKLLERGIITQPGYLK-PIYAVCLQFKPIR--YYKEVIKS 303
            .|.   .|...|.| ::||...  |.:..:..|:....:|| ...|....::|.:  .:..|..:
  Fly   334 LRPAECPVPDVSAG-QVGLIAC--NMRNSKESIVGDTIHLKNQAVAAAGSYRPQQPLVFAGVFPA 395

  Fly   304 MRKMHISVGHNTVMANVTLFRDTDGTTSTFQLDKEYEYMEDVQPAEVQ----------HNDVIYA 358
            .:..|:::  .:.:..:.|    :.:..|.::|.        .||..|          |.:|...
  Fly   396 DQSKHVAL--RSAIDKMVL----NDSAVTVKIDS--------SPALGQGWRLGFLGLLHMEVFCQ 446

  Fly   359 LLQFE---SPVLSPPHST--LIAS---------KLDMDVHSTSCRLAFWGRIAWQTHSSKYFQEE 409
            .|:.|   .|:::.|..|  |:.|         :..||:.:.:        :..:.||.|.:.|.
  Fly   447 RLEQEHGAEPIITAPSVTYRLVLSNPKMIKQQGRDTMDISNAA--------LFPEPHSIKEYYEP 503

  Fly   410 LPKLRIFKRKQKVGSIQRVVNSSEVIVQNLFKDAKRDLYVGKNVELSTGEKGRIERTFGQTSKVA 474
            |          .:|:|   :..:|              |||:.:.|.      :||...|.|.|
  Fly   504 L----------VLGTI---ITPTE--------------YVGQVISLC------VERRGLQQSSV- 534

  Fly   475 ITFQDALSPETISNVKNVKVLLNCKKYV 502
                         |:.:.:||:   |||
  Fly   535 -------------NIDDTRVLM---KYV 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEFSec	NP_611584.1	SelB_euk	5..192	CDD:206676	55/198 (28%)
		SelB	6..467	CDD:225815	114/502 (23%)
		SelB_II	196..278	CDD:293897	22/84 (26%)
		eSelB_III	283..396	CDD:294009	21/138 (15%)
waw	NP_001027089.1	PRK05433	94..695	CDD:235462	127/548 (23%)
		LepA	100..277	CDD:206677	54/195 (28%)
		EF4_II	285..370	CDD:293900	22/88 (25%)
		EF4_III	386..461	CDD:293917	13/88 (15%)
		lepA_C	502..581	CDD:239680	20/95 (21%)
		LepA_C	589..695	CDD:283959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840