Protein Alignment eEFSec and EIF2S3B

DIOPT Version :10

• Sequence 1: NP_611584.1
• Gene: eEFSec / 37444
• FlyBaseID: FBgn0034627
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001344663.1
• Gene: EIF2S3B / 255308
• HGNCID: 43863
• Length: 472
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 117/511 - (22%)
• Similarity: 195/511 - (38%)
• Gaps: 163/511 - (31%)

  Fly     6 NIGLLGHVDSGKTTLAKALSSISSTAAFDKNPQSVERGITLDLGFSGLLV--------------- 55
            |||.:|||..||:|:.||:|.: .|..| ||  .:||.||:.||::...:
Human    43 NIGTIGHVAHGKSTVVKAISGV-HTVRF-KN--ELERNITIKLGYANAKIYQLDDPSCPRPECYR 103

  Fly    56 --------DAPAHLPQGEQLQF------TFVDCPGHASLIRTIIGGAQIIDLMLLVVDAQKG-KQ 105
                    :.|..:| |.:..|      :|||||||..|:.|::.||.::|..||::...:. .|
Human   104 SCGSSMPDEFPTDIP-GTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQ 167

  Fly   106 TQTAECLIIGELLQKKLIVVI-NKIDVYPENQRASKLEKLRLRLAKTLEATTFGGQVPICAVSAL 169
            .||:|.|...|:::.|.|::: ||||:..|.|...:.|::   || .::.|...| .||..:||.
Human   168 PQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQI---LA-FVQGTVAEG-APIIPISAQ 227

  Fly   170 QGTHIAELREVLREAYFQPQRNLADPLFMYVDHCFGIKG--------QGTVCTGTLLQGKVQVNN 226
            ...:|..:.|.:.:....|.|:......:.|...|.:..        :|.|..|::|:|.::|
Human   228 LKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKV-- 290

  Fly   227 VIELPALGEQRKVKSIQMFRKNVTSASMGDRIGLCVTQFNAKLLERGIITQPGYLKPIYAVCLQF 291
                   |::.:|                 |.|:.......||:.:.|                |
Human   291 -------GQETEV-----------------RPGIVSKDSEGKLMCKSI----------------F 315

  Fly   292 KPIRYYKEVIKSMRKMHISVGHNTVMANVTLFRDTDGTTSTFQLDKEYEYMEDVQPAEVQHNDVI 356
            ..|                         |:||                          .:|||:.
Human   316 SKI-------------------------VSLF--------------------------AEHNDLQ 329

  Fly   357 YALLQFESPVLSPPHSTLIASKLDMDVHSTSCRL-AFWGRIAWQTHSSKYFQEELPKLRIFKRKQ 420
            ||         :|.....:.:|:|    .|.||. ...|:|.....:......|| ::..|..::
Human   330 YA---------APGGLIGVGTKID----PTLCRADRMVGQILGAVGALPEIFTEL-EISYFLLRR 380

  Fly   421 KVGSIQRVVNSSEVIVQNLFKDAKRDLYVGKNVELSTGEKGRIERTFGQTSKVAIT 476
            .:| ::...:.....||.|.|:....:.:|   .||||  ||:........|:.:|
Human   381 LLG-VRTEGDKKAAKVQKLSKNEVLMVNIG---SLSTG--GRVSAVKADLGKIVLT 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eEFSec	NP_611584.1	SelB_euk	5..192	CDD:206676	67/216 (31%)
		SelB_II	196..278	CDD:293897	15/89 (17%)
		eSelB_III	283..396	CDD:294009	17/113 (15%)
EIF2S3B	NP_001344663.1	PTZ00327	13..466	CDD:240362	117/511 (23%)