DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEFSec and efsc-1

DIOPT Version :9

Sequence 1:	NP_611584.1	Gene:	eEFSec / 37444	FlyBaseID:	FBgn0034627	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_493275.1	Gene:	efsc-1 / 173172	WormBaseID:	WBGene00008133	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	159/518 - (30%)
Similarity:	263/518 - (50%)	Gaps:	66/518 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NIGLLGHVDSGKTTLAKALSSISSTAAFDKNPQSVE----RGITLDLGFSGLLVDAPAHLPQGEQ 66
            |:|:|||||||||||.:.::.:.||:|||.:..|..    |..|||||||.:.      ...|.:
Worm    15 NLGILGHVDSGKTTLTRRIAELGSTSAFDAHATSTTTDGIRRNTLDLGFSTMT------SLSGRR 73

  Fly    67 LQFTFVDCPGHASLIRTIIGGAQIIDLMLLVVDAQKGKQTQTAECLII-GELLQKKLIVVINKID 130
            |  ..:|||||:.|||.::..:.:.|:.::::|...|.|.||||.|:: .:....::|:|:||.|
Worm    74 L--ALIDCPGHSGLIRAVLAASTVFDMAIVIIDVVAGIQPQTAEHLLLASKFCPNRVIIVLNKCD 136

  Fly   131 VYPENQRASKLEKLRLRLAKTLEATTFGGQVPICAVSALQGTHIAELREVLREA----YFQPQRN 191
            :..:::.:...:|:|    |.|::.......||..:|...|....|:.:.|:.|    .|:|:|:
Worm   137 LAEKSKISESAKKVR----KGLKSMGVDENSPIVEMSLADGYFKEEMLQNLKLAIESRIFEPKRD 197

  Fly   192 LADPLFMYVDHCFGIKGQGTVCTGTLLQGKVQVNNVIELPALGEQRKVKSIQMFRKNVTSASMGD 256
            ......:.:||||.|||||||.|||:::|.:::|..||.|||.|:|:||:::.:::.|...:.|.
Worm   198 EEGEFLIAIDHCFAIKGQGTVLTGTVIRGVLRLNTEIEFPALNEKRRVKTLETWKQRVGQVAAGA 262

  Fly   257 RIGLCVT-QFNAKLLERGIITQPGYLKPIYAVCLQFKPIRYYKEVIKSMRKMHISVGHNTVMANV 320
            |....|. .|:.....|.|....|.||....|....:||:::::.|.|..|:|::|...||||..
Worm   263 RAAFLVAPSFDEHRFSRCICGPLGTLKSTKFVLATVEPIQFFRKSINSKSKIHVAVAFETVMAEC 327

  Fly   321 TLFRDTDGTTSTFQLDKEYEYMED-VQPAEVQHNDVIYALLQFESPVLSPPH--STLIASKLDMD 382
            ...::.:        :.|:|.:.. :.|.:|        |..||..:..|.:  :..:|::|:..
Worm   328 QFLKEKE--------NGEFEMLPSLLAPCQV--------LFSFEKSIFLPENYSNPFMAARLEQQ 376

  Fly   383 VHSTSCRLAFWGRIAWQTHSSKYFQEELPK-----LRIFKRKQKVGSIQRVVNSS-EVIVQNLFK 441
            ..| .||.||.|          .|.:.||:     ...|.||.:.|.::||.... ..|...:||
Worm   377 PGS-GCRFAFSG----------IFSQILPENGKNLPPRFTRKCRKGHVERVEKDGFSAICTGMFK 430

  Fly   442 -DAKRDLYVGKNVELSTGEKGRIERTFGQTSKVAITFQDALSPETISNVKNVK--VLLNCKKY 501
             :...|::.|..:..|:|.:|:||..||::.|..:||     .|.|..:...|  :.|..|||
Worm   431 AETNFDVFRGFQICTSSGPRGKIEGAFGKSGKFRVTF-----AEKIDGILTEKEEISLFLKKY 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEFSec	NP_611584.1	SelB_euk	5..192	CDD:206676	65/194 (34%)
		SelB	6..467	CDD:225815	147/480 (31%)
		SelB_II	196..278	CDD:293897	32/82 (39%)
		eSelB_III	283..396	CDD:294009	28/115 (24%)
efsc-1	NP_493275.1	SelB	14..493	CDD:225815	159/518 (31%)
efsc-1	NP_493275.1	P-loop_NTPase	15..189	CDD:393306	62/185 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165659
Domainoid	1	1.000	99	1.000	Domainoid score	I4468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11073
Inparanoid	1	1.050	216	1.000	Inparanoid score	I2328
Isobase	1	0.950	-	0	Normalized mean entropy	S2647
OMA	1	1.010	-	-		QHG55121
OrthoDB	1	1.010	-	-		D370293at33208
OrthoFinder	1	1.000	-	-		FOG0007177
OrthoInspector	1	1.000	-	-		oto18696
orthoMCL	1	0.900	-	-		OOG6_103847
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3582
SonicParanoid	1	1.000	-	-		X5287
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890