DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17974 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_611582.1	Gene:	CG17974 / 37441	FlyBaseID:	FBgn0034624	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	214	Identity:	57/214 - (26%)
Similarity:	84/214 - (39%)	Gaps:	46/214 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KADFLHAHNKRRNFLALGKVPGYYPAARMATMVWDDELQYLSMLNTRTCKLDHDDCHNTYRYANS 127
            |.:.|..|||.|     |:|..  .|:.|..|.|||||:..:......|..:|..   |....:.
Human    56 KEEILMLHNKLR-----GQVQP--QASNMEYMTWDDELEKSAAAWASQCIWEHGP---TSLLVSI 110

  Fly   128 GQNLCAVW-RPRSPHVNVTSLVEECLGLWFNEFDLIDSSFIDSFKVTPIFED------YGHFAEL 185
            ||||.|.| |.|||..:|.|        |::|  :.|.::....:..|...:      ..|:.::
Human   111 GQNLGAHWGRYRSPGFHVQS--------WYDE--VKDYTYPYPSECNPWCPERCSGPMCTHYTQI 165

  Fly   186 SVDKNFAVGCSIMRFTRPDY------PSVYIYNFICNYASL-YALGAPVYETGRAASRCTTGKSH 243
            .......:||::....:...      .:||   |:|||:.. ..:|...|:.||..|.|...
Human   166 VWATTNKIGCAVNTCRKMTVWGEVWENAVY---FVCNYSPKGNWIGEAPYKNGRPCSECPPS--- 224

  Fly   244 FYPG-----LCSTREVYDP 257
             |.|     ||...|.|.|
Human   225 -YGGSCRNNLCYREETYTP 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17974	NP_611582.1	SCP_euk	63..218	CDD:240180	43/167 (26%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	43/167 (26%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151219
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10334
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850