Protein Alignment KCNA10 and Shawl

DIOPT Version :9

• Sequence 1: NP_005540.1
• Gene: KCNA10 / 3744
• HGNCID: 6219
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 167/563 - (29%)
• Similarity: 258/563 - (45%)
• Gaps: 165/563 - (29%)

Human    83 EGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQS 147
            :|..|:|:|::|:|:||...||.:.|.|.|....:.:..:|.:.|||||||:...|..||.||::
  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT 66

Human   148 GGKIRRPANVPIDIFADEISFYELGSEAMDQ--------FREDEGFIK-----DPETLLPTND-- 197
             ||:..|.:|...:|.:|:.|:.|.|..::.        .|:.:..:.     |.|...||.:
  Fly    67 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQI 130

Human   198 --------------------IHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFR 242
                                |..:.|.:|:.|.||:.|:.||.:||..:.:|:..|||:|.|.||
  Fly   131 ARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFR 195

Human   243 ED--------------------------------------------------------------- 244
            .|
  Fly   196 VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260

Human   245 ---------------RELKVVRDPNLNMSKTVLSQTM------------------FTDP---FFM 273
                           :.||      .|::.::|::.:                  :..|   ||.
  Fly   261 SGQATPIATIKGGQRQRLK------RNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFY 319

Human   274 VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLA 338
            ||..|.|||..|:::|.:|.|:...|.::.:||||..:.:.::..::..:.:.|          .
  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYT----------G 374

Human   339 ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--VDEP 401
            :|....:||:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|.|
  Fly   375 LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNP 439

Human   402 ESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHR 466
            ::.|.|||.|.|||:||||||||||:.|.|..|..||.|||:|||||||||||||||||:.||
  Fly   440 DNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY-- 502

Human   467 ETENEEKQNIPGEIERIL---------NSVGSRMGSTDSLNKT 500
             :..:.:..:|.:..|:|         .......|.|:::.:|
  Fly   503 -SHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQT 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..50
		BTB_2	88..179	CDD:308049	33/98 (34%)
		Ion_trans	255..467	CDD:306908	99/234 (42%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	489..511		3/12 (25%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	33/92 (36%)
		BTB_2	7..97	CDD:280393	33/90 (37%)
		Ion_trans	307..506	CDD:278921	97/211 (46%)
		Ion_trans_2	<449..499	CDD:285168	38/49 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810