DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNA10 and Shab

DIOPT Version :9

Sequence 1:	NP_005540.1	Gene:	KCNA10 / 3744	HGNCID:	6219	Length:	511	Species:	Homo sapiens
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	183/502 - (36%)
Similarity:	263/502 - (52%)	Gaps:	69/502 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    39 GRPGGSSFSNGKILISEST-------NHETAFSKLPGDYADPPGPEPVVLNEG-NQRVIINIAGL 95
            |.....|.|.|....|:|.       .|..:.|.:|     ||.|..:..::. |.||.||:.|:
  Fly   257 GGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIP-----PPEPFMIAQSKAVNSRVSINVGGV 316

Human    96 RFETQLRTLSQFPETLLG------DREKRMQFFDSMR---NEYFFDRNRPSFDGILYYYQSGGKI 151
            |.|...|||.:.|.|.||      ..|..::..|...   |||||||:..||..||.:|:: ||:
  Fly   317 RHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKL 380

Human   152 RRPANVPIDIFADEISFY---ELGSEAMDQFR-------EDEGFIKDPETLLPTN---------- 196
            .....:.:..|:|::.::   ||..|:..|.:       ..|...|:.|:|...:
  Fly   381 HIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCA 445

Human   197 DIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTV 261
            :..:..|.|.|.|.:|.|||.:||:|:|.:|:|.....|.|||:.:.........:|.|
  Fly   446 EYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQL------ 504

Human   262 LSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQE 326
                      .|||:.||.|||.|.:|||...|.|..||:..:||||:::|:|||.:|   .:.|
  Fly   505 ----------AMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL---FLLE 556

Human   327 TEPSAQQNMS--LAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 389
            |..:|.....  ..::::.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::|
  Fly   557 TNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIF 621

Human   390 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVP 454
            ||..||||.||.::.|.|||:.||||.:|||||||||:.|||..||::||:|.|.|||.||||:|
  Fly   622 SSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIP 686

Human   455 VIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTN 501
            :||:||..||..:...|:.......::|     ..|.||..|.:..|
  Fly   687 IIVNNFAEFYKNQMRREKALKRREALDR-----AKREGSIVSFHHIN 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..50		3/10 (30%)
		BTB_2	88..179	CDD:308049	34/102 (33%)
		Ion_trans	255..467	CDD:306908	104/213 (49%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511		5/13 (38%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	35/107 (33%)
		BTB_2	309..408	CDD:280393	34/99 (34%)
		Ion_trans	501..700	CDD:278921	105/217 (48%)
		Ion_trans_2	613..696	CDD:285168	51/82 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810