DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNA10 and Ork1

DIOPT Version :9

Sequence 1:	NP_005540.1	Gene:	KCNA10 / 3744	HGNCID:	6219	Length:	511	Species:	Homo sapiens
Sequence 2:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	148	Identity:	26/148 - (17%)
Similarity:	52/148 - (35%)	Gaps:	60/148 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   377 LLIFFLFIGVILFSSAVYF----------------AEV------------------DEPESHFSS 407
            :|:...:|..::|.:|:|:                |::                  ||.....|.
  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISD 71

Human   408 IPD--------------------GFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALP 452
            ..|                    .|::|....:|||||::.|||..|:::....::.|:     |
  Fly    72 YCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI-----P 131

Human   453 V-PVIVSNFNYFYHRETE 469
            | .::.:....::.|..|
  Fly   132 VNGILFAGLGEYFGRTFE 149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..50
		BTB_2	88..179	CDD:308049
		Ion_trans	255..467	CDD:306908	24/144 (17%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	14/58 (24%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000