DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NCR3LG1 and Ncr3lg1

DIOPT Version :9

Sequence 1:	NP_001189368.1	Gene:	NCR3LG1 / 374383	HGNCID:	42400	Length:	454	Species:	Homo sapiens
Sequence 2:	XP_017445618.1	Gene:	Ncr3lg1 / 691092	RGDID:	1588614	Length:	379	Species:	Rattus norvegicus

Alignment Length:	311	Identity:	126/311 - (40%)
Similarity:	179/311 - (57%)	Gaps:	28/311 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    12 ALLILLWA-LTTEGDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFD-K 74
            :||:|||: |.:.|.|::| |||.|||..|:::|||.|.|..|..|:::.:|:.|   ||..| .
  Rat    71 SLLLLLWSLLPSAGGLELE-MAGTTQIVFLHEDVTIPCKILGSLHLDLSIVGVIW---SLKKDGD 131

Human    75 EVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEV 139
            |.:||:|:||..||.||||.||...|:.|||||.||..:|.|||||:|:|||||.|.:||.:|||
  Rat   132 ESEVFKFYGDQLEAVRPGANVSLLGLEHGDASLYLPRFELWEAGEYQCKVVVTPEKKEGTTRLEV 196

Human   140 VASPASRLLLDQVGMKENEDK-YMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNM 203
            ||.|...|.......:..::| .:|:..||||||::|.|.....|..|..||:|.|:||||:||.
  Rat   197 VAHPNMSLSEKPATARGGKEKLIICQLDGFYPEALDIKWMGSALKDSHFQEITEGVVTGPTVKND 261

Human   204 DGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSIHWWP- 267
            ||||:|||.|.|..:.||  .:|||||.|.|...|  .:..:|...::...|..|...:....|
  Rat   262 DGTFSVTSSLALKPALED--HMYQCVVWHRSWLMP--QSLNVTVFENTRDSTHGTVPPTAEVGPP 322

Human   268 ----------ISFIGVGLVLLIVLI----PWKKICNKSSSAYTPL--KCIL 302
                      ::.||:.::|..|::    .||::...::.....|  :|.|
  Rat   323 VSEPRSVMIYVTIIGLCILLFSVIVCGLWKWKRLTTSNTGLCLRLDVRCCL 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCR3LG1	NP_001189368.1	Ig	42..135	CDD:325142	48/93 (52%)
		Interaction with NCR3. /evidence=ECO:0000269\|PubMed:19528259	59..62		0/2 (0%)
		Ig	105..240	CDD:325142	68/135 (50%)
		Interaction with NCR3. /evidence=ECO:0000269\|PubMed:19528259	127..130		2/2 (100%)
		Retroviral-Gag-like	291..429		3/14 (21%)
		Gag_MA	296..>377	CDD:307339	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..454
Ncr3lg1	XP_017445618.1	IG_like	94..196	CDD:214653	54/104 (52%)
		Ig	99..197	CDD:299845	52/100 (52%)
		IgC	203..299	CDD:143166	42/99 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.500