DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NCR3LG1 and dhrs13b.2

DIOPT Version :9

Sequence 1:	NP_001189368.1	Gene:	NCR3LG1 / 374383	HGNCID:	42400	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_001077299.1	Gene:	dhrs13b.2 / 559844	ZFINID:	ZDB-GENE-080303-14	Length:	436	Species:	Danio rerio

Alignment Length:	222	Identity:	58/222 - (26%)
Similarity:	100/222 - (45%)	Gaps:	25/222 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    67 WKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKA 131
            |:.....:..|:|.:.....::...|..|.  .:..|:||.:|...:....|.|.|.|:|.||..
Zfish   216 WRLQRHGERTKLFSYSSRTGKSEGKGVTVK--TIAGGNASFKLEPTRKHSEGTYVCSVMVPPLYG 278

Human   132 QGTVQLEVVASPASRLLL-DQVGMKENED-KYMCESSGFYPEAINITWEKQTQKFPH-----PIE 189
            ...:.|.:...|...|.: ..:.|...:| |.:||:..:||..::|.|.::    ||     |:.
Zfish   279 SHDIPLSLSEQPRVSLNVGSTLSMVIGQDQKLICEAESYYPLDVDIEWYRE----PHGGSPTPLF 339

Human   190 ISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSE 254
            :...:.:...| :.|||:::::...|....||.|..|.|.|.|.||.||:|.:|.|.|     :|
Zfish   340 LKNVLYSSHRI-HQDGTYSLSAFFYLQPGLEDSGYKYTCRVSHKSLLTPVRKSFYLVA-----TE 398

Human   255 TEKTDNFSIHWWPISFIGVGLVLLIVL 281
            .:.|      .|.|:..|..:.:|::|
Zfish   399 PDST------MWYIAVFGFIIAMLVIL 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NCR3LG1	NP_001189368.1	Ig	42..135	CDD:325142	16/67 (24%)
		Interaction with NCR3. /evidence=ECO:0000269\|PubMed:19528259	59..62
		Ig	105..240	CDD:325142	41/141 (29%)
		Interaction with NCR3. /evidence=ECO:0000269\|PubMed:19528259	127..130		1/2 (50%)
		Retroviral-Gag-like	291..429
		Gag_MA	296..>377	CDD:307339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..454
dhrs13b.2	NP_001077299.1	Ig	185..275	CDD:299845	14/60 (23%)
dhrs13b.2	NP_001077299.1	IgC_Tapasin_R	252..391	CDD:143248	42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910