DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and Slc38a10

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_006534347.1	Gene:	Slc38a10 / 72055	MGIID:	1919305	Length:	1111	Species:	Mus musculus

Alignment Length:	858	Identity:	231/858 - (26%)
Similarity:	386/858 - (44%)	Gaps:	198/858 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72
            :..:.|||:||.:|.|||||::|||:|..:|||..:.:|...|.:|:|::.|::||::..|..||
Mouse    12 ITNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHA 76

  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSLVMVVVTVVCIVP 137
            :|.:||:|||..:||.::|:|||::||:||||....|.:..|.|.  ..:|..::..|::..::|
Mouse    77 YGKAGKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGLQVT--RTVRVFLLFAVSLFIVLP 139

  Fly   138 LGMLRN----VDSLSAVCTASIGFYVCLILKIVLEAQPH-ITANDWTEKVLY--WEPAGVLQCLP 195
            |.:.||    :.|.||:   ::.||...:..|||.:..| :.:..|..:|.|  ||  ||.:|:|
Mouse   140 LSLQRNMMASIQSFSAM---ALLFYTVFMFVIVLSSLKHGLFSGQWLRQVSYIRWE--GVFRCVP 199

  Fly   196 IFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNILVN 260
            ||.|:.:||.|:...::|::..|:..::.|..::..:.|..|:.|||||||:| |...:||:|::
Mouse   200 IFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTAFYVMVGFFGYVSF-TDATTGNVLIH 263

  Fly   261 LSTSFGSDIIKIGFVLSIAFSFPLVIFPCRASLYSLLY----RKGHTESSSYIPEQRFRFITIFI 321
            ..::..:::|::|||:|:|..||::|.|||.:|.:||:    :.|...:..|:|..||:.:|:.:
Mouse   264 FPSNPVTEMIRVGFVMSVAVGFPMMILPCRQALNTLLFEQQQKDGTFAAGGYMPPLRFKVLTLSV 328

  Fly   322 VVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKESMERTLAQFVFVSGFLLMIL 386
            |..::...::||:||.|:|..|:|:|..||.:.||    .|.||.......||.|...|..::::
Mouse   329 VFGTMVGGVMIPNVETILGFTGATMGSLICFICPA----LIYKKAHKNAPSAQVVLWVGLGILVV 389

  Fly   387 GTYANLSAIDEKSSGPEFDMVAIGTPLYPDGQVPAVVGELPKHLAKESI-----DSEKNLLLK-- 444
            .|...||                            |..|.|..|.:|:.     |:|..:.::
Mouse   390 STLTTLS----------------------------VTEEAPLDLTQEARSGHRGDAEGAMKVEAA 426

  Fly   445 KLDVQNP---------DKLKQTVEDKV---------VDMP------EVVQSASSDNP------PL 479
            :|.||:|         :|||...:.:|         ||:|      |..::|..|.|      |:
Mouse   427 RLSVQDPVVVVAEDSQEKLKPAEDKEVLEQAQIKGPVDVPGGEAPKEKQEAAQLDRPGQGIAVPM 491

  Fly   480 -------PPLPIDEVHVVPIDSKNSETDIKKLPVEAVEANPPEAKPLDVNLTVDKPKNNPPAVAA 537
                   ||:|.|:  ||..:.::.|             .|.|.||             ||
Mouse   492 GEAHRHEPPIPHDK--VVVDEGQDQE-------------GPEEKKP-------------PP---- 524

  Fly   538 SLPDK----------PKIGSSLLSASNTIDGAAIKKEEDVAA-----EEQKESKANADELLKTQK 587
            .|||:          |.:..|.........|...|:...|.|     ..||..:||....::.:|
Mouse   525 RLPDEGDPAGRGQGAPPLPESEKEKQEPERGGEGKRPGQVLAVGETEHPQKVPEANGQPPVQPRK 589

  Fly   588 E--------------LKETKKLLAKTVGELNEELAKKNSFNQPPLELQKDEPLDTGAKF---AEE 635
            |              .:::.:|.|....:..|...|.......|:|...:.  |.|.|.   .:.
Mouse   590 EDSRPGNRDPQPAAQARDSVELKALAADDGREPAQKAGGALWKPVESAAES--DAGGKAGLPVQR 652

  Fly   636 PKKAEIKLKESQPVADEKKERRRQASLMDILTENTHLRDEKEAHAGVFEPLSY------KTGELL 694
            |:.||.:         ||||..:|..      :....:.|:|...|....||.      :|.|:.
Mouse   653 PEAAEQR---------EKKEAEQQGG------DQAGSKLEEETFHGFLLCLSSICLSMGRTAEIK 702

  Fly   695 -------RNSTVDKEALIKRLPIPLALMVNSTQPKSSNDSEIKKPNLEDNVEAIRRELLNLRSSA 752
                   |...:|...|::      .:.....|.|...|.:.|   |...:|...:|:...|...
Mouse   703 KLVAEAGRAEMLDHAVLLQ------VIQEQQVQQKRLLDQQEK---LLAVIEEQHKEIRQQRQEG 758

  Fly   753 DATEQPPARVKRE 765
            :..:..||.|:.|
Mouse   759 EEDKPKPADVQPE 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	139/394 (35%)
		SLC5-6-like_sbd	8..390	CDD:294310	139/392 (35%)
		DUF4775	<394..652	CDD:292620	63/333 (19%)
		YukC	<561..660	CDD:295067	25/120 (21%)
Slc38a10	XP_006534347.1	SLC5-6-like_sbd	6..381	CDD:382020	137/380 (36%)
		PTZ00121	<407..789	CDD:173412	86/423 (20%)
		PTZ00449	<731..>991	CDD:185628	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833982
Domainoid	1	1.000	262	1.000	Domainoid score	I1943
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4715
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006930
OrthoInspector	1	1.000	-	-		oto94142
orthoMCL	1	0.900	-	-		OOG6_106866
Panther	1	1.100	-	-	LDO	PTHR22950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4114
SonicParanoid	1	1.000	-	-		X5024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680