DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and slc38a2

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001038569.1	Gene:	slc38a2 / 566537	ZFINID:	ZDB-GENE-030131-9659	Length:	504	Species:	Danio rerio

Alignment Length:	438	Identity:	109/438 - (24%)
Similarity:	200/438 - (45%)	Gaps:	58/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72
            |..|.|:|:|.|||.:.:.....||.:.::|||.....:....|.|:||:.......:|.||..|
Zfish    80 VFNLGNAIMGSGILGLSYAMANTGIAMFVILLVAVAIFSLYSVHLLLKTANEGGSLVYEQLGYKA 144

  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRS--LVMVVVTVVCI 135
            ||..|||.....|.....|...:|..:|....| |:.:.| ||..|:....:  .::::||:..|
Zfish   145 FGIPGKLAASCSITMQNFGAMASYLYIVKYELP-IVIRAF-LDSNDNAWYTNGDYLVLIVTMSII 207

  Fly   136 VPLGMLRNVDSL------SAVCTASIGFYVCLILK---------------IVLEAQPHITANDWT 179
            :||.:|:|:..|      |.:|  .:.|.:.:|.|               .|..:||..|.|...
Zfish   208 LPLSLLKNLGYLGYTSGFSLLC--MVFFLIVVIYKKFQIPCPLPENFINITVNVSQPPQTNNSTD 270

  Fly   180 EKVLYWEP------AGVLQCLPIFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFV-Y 237
            |:..  :|      :..:..:||.:.|..|...:..::|.:.::|..|:.. |.|.:::..|: |
Zfish   271 EECC--KPKYFIFNSQTVYAVPILTFAFVCHPAILPMYEELKDRSRRKMQN-VANVSFLGMFIMY 332

  Fly   238 ISVGFFGYVAFCTHTFSGNILVNLSTSFGSD----IIKIGFVLSIAFSFPLVIFPCRASLYSLLY 298
            :....|||:.| .......:|...|..:..|    |:::..:.::..:.|:|:||.|.|:..||
Zfish   333 LLAALFGYLTF-NEAVEPELLHTYSKVYNFDVVLLIVRLAVLTAVTLTVPVVLFPIRTSVNHLL- 395

  Fly   299 RKGHTESSSYIPEQRFRFITIFIVVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKII 363
              |.::..|:   .|...||:.::|....:.:.:|::..|.|.:|::....:..:.|::.:.|::
Zfish   396 --GASKEFSW---PRHICITVALLVCVNILVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLV 455

  Fly   364 KKESM---ERTLAQFVFVSGFLLM-------ILGTYANLSAIDEKSSG 401
            |||||   ::..|....:.|||:|       |:....|..:.:|.:.|
Zfish   456 KKESMKSVQKIGATLFLIMGFLVMTGSMALIIMDWIHNALSSEEHTGG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	106/427 (25%)
		SLC5-6-like_sbd	8..390	CDD:294310	106/425 (25%)
		DUF4775	<394..652	CDD:292620	2/8 (25%)
		YukC	<561..660	CDD:295067
slc38a2	NP_001038569.1	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..99		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		SdaC	70..479	CDD:223884	104/412 (25%)
		SLC5-6-like_sbd	72..488	CDD:294310	105/421 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840