DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30394 and slc38a10

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_017214041.1	Gene:	slc38a10 / 561739	ZFINID:	ZDB-GENE-050309-21	Length:	1132	Species:	Danio rerio

Alignment Length:	949	Identity:	241/949 - (25%)
Similarity:	424/949 - (44%)	Gaps:	215/949 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72
            :|.:.|||:||.:|.|||||::|||:|..:||...:.:|...|.:|:.::..|:||::..|..||
Zfish     9 IMNVVNSIVGVSVLTMPFCFKQCGIVLGTLLLFFCSWMTHQSCMFLVHSASNTKRRTYAGLAFHA 73

  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSLVMVVVTVVCIVP 137
            :|..||.||||.:||.::||||.::||:.:||....|::..|.|..  ..|.:::..|::..::|
Zfish    74 YGKPGKALVELSMIGLMLGTCIAFYVVIAELGSNFFAQLLGLQVTG--SFRVVLLFAVSLFIVLP 136

  Fly   138 LGMLRN-VDSLSAVCTASIGFYVCLILKIVLEAQPH-ITANDWTEKVLY--WEPAGVLQCLPIFS 198
            |.:.|| :.|:.:....::.||...:..:||.:..| :....|..||::  |:  ||.:|:||..
Zfish   137 LSLQRNMMSSIQSFSAMALIFYTLFMFTMVLSSLKHGLLTGQWLNKVIFVRWD--GVFRCIPICG 199

  Fly   199 MALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNILVNLST 263
            ||.:||.|:...::|::..|:.:::.|..::..:.|..||:|||||||:| |...:||:|:|..:
Zfish   200 MAFACQSQVLPTYDSLDEPSVKRMSTIFTSSLNVVTTFYITVGFFGYVSF-TDNIAGNVLMNFPS 263

  Fly   264 SFGSDIIKIGFVLSIAFSFPLVIFPCRASLYSLLY----RKGHTESSSYIPEQRFRFITIFIVVF 324
            :..:::|::||::|:|..||::|.|||.::.::|:    :.|...:..|:|..||:.||:.||..
Zfish   264 NLVTEMIRVGFMMSVAVGFPMMILPCRQAINTMLFEQQQKDGTFAAGGYMPPLRFKSITLCIVFG 328

  Fly   325 SLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKESMERTLAQFVFVSGFLLMILGTY 389
            ::.|.::||:||.|:||.|:|:|..||.:.||..::||:|    ....||.|...|..::::.|.
Zfish   329 TMFVGILIPNVETILGLTGATMGSLICFICPALIYKKIMK----NAWTAQLVLWVGLGILLISTA 389

  Fly   390 ANLSAIDEKSSGPEFDMVAIGTPLYPDGQVPA-VVGELPKHLAKESIDSEKNLLLKKLDVQNPDK 453
            ..:|.   .|:.|        ..:.|...||| ...:||..:|.|         |.|:.||
Zfish   390 TTMSI---SSNEP--------AKITPAQDVPAKTENKLPNIIAPE---------LPKVPVQ---- 430

  Fly   454 LKQTVEDKVVDMPEVVQSASSDNPPLPPLPIDEVHVVPIDSKNSETDIKKLPVEAVEANPPEAKP 518
                 |::|...|       .:.|..||:.:::    |.:.|..|....|:||:.||....|.:
Zfish   431 -----ENRVEPDP-------GEKPDRPPIEVEQ----PAEKKADEPPQIKVPVDVVEQKKKEEE- 478

  Fly   519 LDVNLTVDKP------------KNNPPAVAASLPDKPKIGSSLLSASNTIDGAAIKKEEDVAAEE 571
                :.:|:|            ::.||.        |..|..:....|..:....||:..:..||
Zfish   479 ----VQLDRPEAGVAVPEGEAHRHEPPI--------PHDGVQIDEIKNQEELEDEKKQPAIVEEE 531

  Fly   572 QKESKANADELLKTQ---------------KELKETKKLLAKTVGELNE----ELAK------KN 611
            :|......:|.|..|               :|.||...:..:.|.:.|:    |..|      |.
Zfish   532 KKLPAREEEEFLAEQGAGQAQEVGSDAVKEEEQKEQDDVEKRAVDKANKVENPEDPKQPLGVHKE 596

  Fly   612 SFNQPPLELQKDEPLDTGAKFAEEPKKA----EIKLKES-------------------------- 646
            ..|.|.::.|..|....|.|..||.:||    |.|.||.
Zfish   597 PENLPEVKQQHGENEADGQKKPEEIEKAPEPQEEKPKEKIVEEHKDEKVPDGKDGGAEKDGDGDK 661

  Fly   647 ------------------QPVADEKKERRR----QASLMDILTE---NTHLRDEKEAH------- 679
                              |.:.:::::::|    |..|:.::.|   ..|..|::|.|
Zfish   662 MEVIKKIVAEGQLDHMLLQVIKEQQEQQKRLLDQQEKLLAVIEEQHKEIHHLDQEEKHLPVNDVV 726

  Fly   680 ----AGVFEPLSYKTGE-------LLRNSTVDKEALIK-------------------RLPIPLAL 714
                .|..||.:...||       .:.....|....:|                   ::|:.:|:
Zfish   727 PQVKEGEAEPKAPAAGEGASEVENAVPKQQEDIAVAVKPKVAVDAPEQFQQPQGEPVQVPVAVAV 791

  Fly   715 MVNSTQPKSSNDSEIKKPNLE----DNVEAIRRELLNLRSSADATEQPPARVKREASNDENCLRQ 775
            .......::...:.:.|.:||    ..||..::|.|.|::.....|.....|....       |:
Zfish   792 PEEPAAKEAQAVAGLPKNSLELVQDQGVEVPKKEDLELKNEGVLPEVGARGVPLRQ-------RE 849

  Fly   776 PKLDEVNNNVAAAALSLNMESIGRDLKSIKDDDVEIVTE 814
            |::|::|.:    ||:...|.:.:.|..::.:...|..|
Zfish   850 PEVDKINPD----ALAEKEEKVKQKLAQLEAEKERIEKE 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	136/391 (35%)
		SLC5-6-like_sbd	8..390	CDD:294310	136/389 (35%)
		DUF4775	<394..652	CDD:292620	67/343 (20%)
		YukC	<561..660	CDD:295067	32/175 (18%)
slc38a10	XP_017214041.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576698
Domainoid	1	1.000	267	1.000	Domainoid score	I1832
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2826
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006930
OrthoInspector	1	1.000	-	-		oto40520
orthoMCL	1	0.900	-	-		OOG6_106866
Panther	1	1.100	-	-	LDO	PTHR22950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4114
SonicParanoid	1	1.000	-	-		X5024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780