DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30394 and SLC38A4

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001137296.1	Gene:	SLC38A4 / 55089	HGNCID:	14679	Length:	547	Species:	Homo sapiens

Alignment Length:	478	Identity:	103/478 - (21%)
Similarity:	194/478 - (40%)	Gaps:	117/478 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHAFGT 75
            |:|:|:|.|||.:.:.....||:|.|::|:....::....|.|:||:.......:|.||..|||.
Human    84 LSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGW 148

  Fly    76 SGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDV-ADHLHLR-SLVMVVVTVVCIVPL 138
            .||:...:.|....||...:|..::....|::|.....|:. ....:|. :.:::.|:|..|:||
Human   149 PGKIGAFVSITMQNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLIIFVSVGIILPL 213

  Fly   139 GMLRNVDSL------SAVCTASIGFYVCLI------LKIVLEAQPHITAN--------------- 176
            .:|:|:..|      |..|..   |:|.::      :...|....|...|
Human   214 SLLKNLGYLGYTSGFSLTCMV---FFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLP 275

  Fly   177 ------------DWTEKVLYWEPAGV-----------------------------------LQCL 194
                        |:|.:    .|||:                                   ...:
Human   276 NNSESSDVNFMMDYTHR----NPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAI 336

  Fly   195 PIFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNI-- 257
            ||...|..|..::..::..:.::|..|:..:...:......:|:....|||:     ||.|.:
Human   337 PILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYL-----TFYGEVED 396

  Fly   258 --LVNLSTSFGSDI----IKIGFVLSIAFSFPLVIFPCRASLYSLLYRKGHTESSSYIPEQRFRF 316
              |...|..:..||    :::..::::..:.|:|:||.|.|:.:||:           |::.|.:
Human   397 ELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLF-----------PKRPFSW 450

  Fly   317 ITIFIVVFSL-----CVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKE---SMERTLA 373
            |..|::...|     .:.:::|:::.|.|.:|::....:..:.||..:.|::|||   |.::..|
Human   451 IRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFRSPQKVGA 515

  Fly   374 QFVFVSGFLLMILGTYANLSAID 396
            ....|.|...|| |:.| |..||
Human   516 LIFLVVGIFFMI-GSMA-LIIID 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	100/472 (21%)
		SLC5-6-like_sbd	8..390	CDD:294310	99/470 (21%)
		DUF4775	<394..652	CDD:292620	2/3 (67%)
		YukC	<561..660	CDD:295067
SLC38A4	NP_001137296.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		SdaC	71..534	CDD:223884	101/474 (21%)
		SLC5-6-like_sbd	73..535	CDD:294310	101/475 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810