DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30394 and SLC38A2

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_061849.2	Gene:	SLC38A2 / 54407	HGNCID:	13448	Length:	506	Species:	Homo sapiens

Alignment Length:	444	Identity:	113/444 - (25%)
Similarity:	206/444 - (46%)	Gaps:	67/444 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKT-----SLLTRRRSFEM 67
            |..|:|:|:|.|||.:.:.....||.|.|:||...:..:....|.|:||     |||     :|.
Human    77 VFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLL-----YEQ 136

  Fly    68 LGLHAFGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSL----VMV 128
            ||..|||..|||.....|....||...:|..:|....|.:|..:  .::.|...|..|    :::
Human   137 LGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQAL--TNIEDKTGLWYLNGNYLVL 199

  Fly   129 VVTVVCIVPLGMLRNV------DSLSAVCTASIGFYVCLILK------------IVLE------A 169
            :|::|.|:||.:.||:      ..||.:|  .:.|.:.:|.|            |:.|      .
Human   200 LVSLVVILPLSLFRNLGYLGYTSGLSLLC--MVFFLIVVICKKFQVPCPVEAALIINETINTTLT 262

  Fly   170 QP---------HITANDWTEKVLYWEPAGVLQCLPIFSMALSCQMQLFEVFESINNQSLDKLNGI 225
            ||         ::|.||......:...:..:..:||...:..|...:..::|.:.::|..::..:
Human   263 QPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNV 327

  Fly   226 VRNATWICTFVYISVGFFGYVAFCTHTFSGNILVNLSTSFGSD----IIKIGFVLSIAFSFPLVI 286
            .:.:.:....:|:....|||:.|..|..| .:|...|:..|:|    |:::..::::..:.|:||
Human   328 SKISFFAMFLMYLLAALFGYLTFYEHVES-ELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVI 391

  Fly   287 FPCRASLYSLLYRKGHTESSSYIPEQRFRFITIFIVVFSLCVALVIPSVELIIGLVGSTIGVAIC 351
            ||.|:|:..||.      :|......|...||:.|:.|:..:.:.:|::..|.|.:|::....:.
Human   392 FPIRSSVTHLLC------ASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLI 450

  Fly   352 IMFPASSFRKIIKKE---SMERTLAQFVFVSGFLLMILGTYANLSAIDEKSSGP 402
            .:.|::.:.|::|||   |:::..|.|..:||.|:| .|:.| |..:|...:.|
Human   451 FILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVM-TGSMA-LIVLDWVHNAP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	110/432 (25%)
		SLC5-6-like_sbd	8..390	CDD:294310	109/430 (25%)
		DUF4775	<394..652	CDD:292620	2/9 (22%)
		YukC	<561..660	CDD:295067
SLC38A2	NP_061849.2	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..96		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC5-6-like_sbd	69..495	CDD:320982	111/435 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840