DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and slc38a4

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001005944.2	Gene:	slc38a4 / 449771	ZFINID:	ZDB-GENE-041010-14	Length:	538	Species:	Danio rerio

Alignment Length:	473	Identity:	99/473 - (20%)
Similarity:	197/473 - (41%)	Gaps:	98/473 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HSAH------VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRR 62
            |..|      |..|:|:|:|.|||.:.|.....||:|.::||:   |:. :...|.:...|:|.:
Zfish    68 HPGHASFGMSVFNLSNAIMGSGILGLSFAMANTGIILFVILLL---GVA-ILSLYSVHLLLVTAK 128

  Fly    63 RS----FEMLGLHAFGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVAD---HL 120
            ..    :|.||..|||..||:.....|....||...:|..:|....|::|.....|:.:.   :|
Zfish   129 EGGSLIYEKLGERAFGWPGKMAAFGSITLQNIGAMSSYLFIVKYELPEVIRAFLGLEESSGEWYL 193

  Fly   121 HLRSLVMVVVTVVCIVPLGMLRNVDSL---SAVCTASIGFYVCLIL--KIVL------------- 167
            : .:.|:|:|::..|:||.:|:|:..|   |....:.:.|::.:::  |.:|
Zfish   194 N-GNYVVVLVSIGIILPLSLLKNLGYLGYTSGFSLSCMVFFLGVLIYKKTILPCPLPFFFEHGSN 257

  Fly   168 -----------------------------EAQPHITAND--------------WTEKVLYWEPAG 189
                                         ...||...:|              .|.|...:. :.
Zfish   258 VSINGSDAIALYGLHNASALAYMSETAANAVDPHTPLHDSVQFSAHPEDHQDMCTPKYFIFN-SQ 321

  Fly   190 VLQCLPIFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFS 254
            .:..:||.:.|..|..::..::..:.|:|..::..:...:......:|:....|||:.|..|. .
Zfish   322 TVYTVPILAFAFVCHPEVLPIYSELKNRSRRRMQSVSNLSILAMLVMYLLSALFGYLTFYDHV-E 385

  Fly   255 GNILVNLSTSFGSD----IIKIGFVLSIAFSFPLVIFPCRASLYSLLYRKGHTESSSYIPEQRFR 315
            ..:|...:..:..|    ::::..:.::..:.|:|:||.|:|:.:|.:.   .:..|:|   |..
Zfish   386 AELLHTFTKVYKFDTMLLMVRLAVLTAVTLTVPIVLFPIRSSVITLCFA---GKEFSWI---RHF 444

  Fly   316 FITIFIVVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKK---ESMERTLAQFVF 377
            .|...|:.|:..:.:.:|::..|.|.:||:....:..:.||:.:.:::|.   :|.::..|....
Zfish   445 LIAAAILAFNNLLVIFVPTIRDIFGFIGSSAATMLIFILPAAFYLRLVKSLPMKSPQKISALIFL 509

  Fly   378 VSGFLLMILGTYANLSAI 395
            |.|...||    .:||.|
Zfish   510 VVGIFFMI----GSLSLI 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	94/458 (21%)
		SLC5-6-like_sbd	8..390	CDD:294310	94/456 (21%)
		DUF4775	<394..652	CDD:292620	1/2 (50%)
		YukC	<561..660	CDD:295067
slc38a4	NP_001005944.2	DUF4404	3..90	CDD:291055	7/21 (33%)
		SdaC	68..520	CDD:223884	96/468 (21%)
		SLC5-6-like_sbd	72..525	CDD:294310	97/469 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810