DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30394 and Slc38a10

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_002727892.2	Gene:	Slc38a10 / 303740	RGDID:	1306356	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	247/925 - (26%)
Similarity:	409/925 - (44%)	Gaps:	169/925 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72
            |..:.|||:||.:|.|||||::|||:|..:|||..:.:|...|.:|:|::.|::||::..|..||
  Rat    12 VTNVVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKRRTYAGLAFHA 76

  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSLVMVVVTVVCIVP 137
            :|.:||:|||..:||.::|:|||::||:||||....|.:..|.|.  ...|..::..|::..::|
  Rat    77 YGKAGKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGLQVT--RTFRVFLLFAVSLCIVLP 139

  Fly   138 LGMLRN----VDSLSAVCTASIGFYVCLILKIVLEAQPH-ITANDWTEKVLY--WEPAGVLQCLP 195
            |.:.||    :.|.||:   ::.||...:..|||.:..| :.:..|.::|.|  ||  ||.:|:|
  Rat   140 LSLQRNMMASIQSFSAM---ALLFYTVFMFVIVLSSFKHGLFSGQWLQRVSYIRWE--GVFRCVP 199

  Fly   196 IFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNILVN 260
            ||.|:.:||.|:...::|::..|:..::.|..::..:.|..|:.|||||||:| |...:||:|::
  Rat   200 IFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTAFYVMVGFFGYVSF-TDATTGNVLIH 263

  Fly   261 LSTSFGSDIIKIGFVLSIAFSFPLVIFPCRASLYSLLY----RKGHTESSSYIPEQRFRFITIFI 321
            ..::..:::|::|||:|:|..||::|.|||.:|.:||:    :.|...:..|:|..||:.:|:.:
  Rat   264 FPSNLVTEMIRVGFVMSVAVGFPMMILPCRQALNTLLFEQQQKDGTFAAGGYMPPLRFKVLTLSV 328

  Fly   322 VVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKESMERTLAQFVFVSGFLLMIL 386
            |..::...::||:||.|:|..|:|:|..||.:.||    .|.||.......||.|...|..::::
  Rat   329 VFGTMVGGVMIPNVETILGFTGATMGSLICFICPA----LIYKKAHKNAPSAQVVLWVGLGILVV 389

  Fly   387 GTYANLSAIDEKSSGPEFDMVAIGTPLYPDGQVPAVVGELPKHLAKESI---------DSEKNL- 441
            .|...||..:|    ...|:    |.....||.....|.:....|:.|:         ||::.|
  Rat   390 STLTTLSVSEE----APLDL----TQGARSGQRGDAEGAMKVEAARLSVQDPVVVMAEDSQEKLK 446

  Fly   442 ------LLKKLDVQNPDKLKQTVEDKVVDMP------EVVQSASSDNP------PL-------PP 481
                  :|::..::.|           ||:|      |..::|..|.|      |:       ||
  Rat   447 PAEDKEVLEQAQIKGP-----------VDVPGGDTPKEKQEAAQLDRPGQGIAVPMGEAHRHEPP 500

  Fly   482 LPIDEVHVVPIDSKNSETDIK---KLPVEAVEANPPEAKPLDVNLTVDKPKNNPPAVAASLPDKP 543
            :|.|:|.|.....:....:.|   |||.|...|...:..||   |...:.|.:|..
  Rat   501 IPHDKVVVDEGQDQEGPEEKKPPPKLPDEGDPAGRGQGAPL---LPESEKKQDPER--------- 553

  Fly   544 KIGSSLLSASNTIDGAAIKKEEDVAA-----EEQKESKANADELLKTQKE--------------L 589
                          |...|:.|.|.|     ..||..:||....::.:||              .
  Rat   554 --------------GEEGKRPEQVLAVGEIERPQKIPEANGQPPVQPRKEDSRPGNRDLHPVPQA 604

  Fly   590 KETKKLLAKTVGELNEELAKKNSFNQPPLELQKDEPLDTGAKFA-EEPKKAEIKLKE--SQPVAD 651
            :.:.:|.....||..|...|.......|:|...:..:...|..| :.|:.||.:.|.  .||..|
  Rat   605 RVSVELNDLVAGEGKESAQKAGGAPWKPMESAVESNIGGKAGLAVQRPEAAEQREKNEAEQPGGD 669

  Fly   652 E-----------------KKERRRQASLMDILTE----NTHLRDEKEAHAGVFEPLSYKTGELLR 695
            :                 :.|....|.|:.::.|    ...|.|::|....|.|....:..:..:
  Rat   670 QAGSKLEAEIKKLVAEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIRQQRQ 734

  Fly   696 NSTVDKEALIKRLPIPLALMVNSTQPKSSN---DSEIKKPNLEDNVEAIRRELLNL-----RSSA 752
            ....||.......|.|.|.::...:.::.:   ..|.....||||.....:.:|..     ..|.
  Rat   735 EGEEDKPKPADMQPEPGAAVLRGQEEEAEHAGAPDEHAGETLEDNPSQPLQPVLGAPRGHPAPSQ 799

  Fly   753 DATEQPPARVKREASNDENCL------RQP-----KLDEVNNNVAAAALSLNMESIGRDLKSI-K 805
            |..:.|...||..|..|...|      .:|     ||.|.....|........:.:..||:.: |
  Rat   800 DKGQHPLEEVKVLAGRDLADLPAGGSDTEPHGASSKLREDQKGAALKVAEAVRKLVPGDLEPVHK 864

  Fly   806 DDDVEIVTENESYQA 820
            .|..|:....|...|
  Rat   865 PDPAEVPKSPEKQLA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	140/394 (36%)
		SLC5-6-like_sbd	8..390	CDD:294310	140/392 (36%)
		DUF4775	<394..652	CDD:292620	64/317 (20%)
		YukC	<561..660	CDD:295067	27/137 (20%)
Slc38a10	XP_002727892.2	SdaC	3..398	CDD:223884	142/397 (36%)
Slc38a10	XP_002727892.2	SLC5-6-like_sbd	6..381	CDD:294310	138/380 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337519
Domainoid	1	1.000	265	1.000	Domainoid score	I1830
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2851
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006930
OrthoInspector	1	1.000	-	-		oto97664
orthoMCL	1	0.900	-	-		OOG6_106866
Panther	1	1.100	-	-	LDO	PTHR22950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.790