DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and SLC36A3

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001138489.1	Gene:	SLC36A3 / 285641	HGNCID:	19659	Length:	511	Species:	Homo sapiens

Alignment Length:	482	Identity:	105/482 - (21%)
Similarity:	189/482 - (39%)	Gaps:	134/482 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSL--LTRR--RSF------EMLGL 70
            ||.|:|.:|...:..|:|:..|.| |:.|:..|.|..::....  |::|  ::|      .|.||
Human    56 IGTGLLGLPLAIKNAGLLVGPVSL-LAIGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGL 119

  Fly    71 ----------HA------------FGTSGKL---------------------------LVELCII 86
                      ||            ...|||:                           .|...::
Human   120 ETCPNTWLRAHAVWGRWNLALSPRLECSGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLV 184

  Fly    87 GYLIGTCITYFVVVGDLGPQIIAKIFA----------LDVADHLHLRSLVMVVVTVVCIVPLGML 141
            ...:|.|..||:.:.|...|::.|...          |.:...|.:|..:::::..  ::.|..:
Human   185 ITQLGFCSVYFMFMADNLQQMVEKAHVTSNICQPREILTLTPILDIRFYMLIILPF--LILLVFI 247

  Fly   142 RNVDSLSAVCT----ASIGFYVCLILKIVLEAQPH-----ITANDWTEKVLYWEPA-----GVLQ 192
            :|:..||...|    .::| .:.||.:.::|..|:     :.|| |...:|::..|     ||..
Human   248 QNLKVLSVFSTLANITTLG-SMALIFEYIMEGIPYPSNLPLMAN-WKTFLLFFGTAIFTFEGVGM 310

  Fly   193 CLPIFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNI 257
            .||:.:.....|...|.::..::                |...:||.:|..||:.|.:.| ..:|
Human   311 VLPLKNQMKHPQQFSFVLYLGMS----------------IVIILYILLGTLGYMKFGSDT-QASI 358

  Fly   258 LVNLSTSFGSDIIKIGFVLSIAFSFPL-------VIFPCRASLYSLLYRKGHTESSSYIPEQRFR 315
            .:||...:....:|:.:.:.|.|::.|       :|.|.               :.|.:.|....
Human   359 TLNLPNCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPF---------------AISQVSESWAL 408

  Fly   316 FITIFI---VVFSLCV-ALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKESME-RTLAQF 375
            |:.:.:   :|...|| |::||.::|:|.||||....|:.::.||.....|...|.|. .|:|:.
Human   409 FVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIAKD 473

  Fly   376 VFVS--GFLLMILGTYANLSAIDEKSS 400
            :.:|  |.|..|.|||..|..:.:..|
Human   474 IMISIVGLLGCIFGTYQALYELPQPIS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	103/472 (22%)
		SLC5-6-like_sbd	8..390	CDD:294310	102/470 (22%)
		DUF4775	<394..652	CDD:292620	1/7 (14%)
		YukC	<561..660	CDD:295067
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:320982	103/472 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810