DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and SLC36A1

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_011535882.1	Gene:	SLC36A1 / 206358	HGNCID:	18761	Length:	482	Species:	Homo sapiens

Alignment Length:	441	Identity:	111/441 - (25%)
Similarity:	187/441 - (42%)	Gaps:	85/441 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGVGILAMPFCFQKCGILLS-IVLLVLSNGITRV-CCHYLIKTSLLTRRR---SF------EMLG 69
            ||.|:|.:|...:..||::. |.||::  ||..| |...|:|.:....||   ||      .|.|
Human    67 IGTGLLGLPLAVKNAGIVMGPISLLII--GIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYG 129

  Fly    70 LHAFGTS--------GKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSLV 126
            |.:...|        |:.:|:..:|...:|.|..|||.:.|...|:|..  |....::.|....|
Human   130 LESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEA--ANGTTNNCHNNETV 192

  Fly   127 MVVVT----------VVCIVPLGMLRNVDSLSAV-CTASIGFYVCLIL--KIVLEAQP---HI-T 174
            ::..|          :..:|.|..:||:.:||.. ..|:|...|.|::  :.:::..|   |: .
Human   193 ILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPL 257

  Fly   175 ANDWTEKVLYWEPAGVLQCLPIFSMALSCQMQLFEVFESI------NNQSLD--KLNGIVRNATW 231
            ...|....|::..|       |||            ||.|      .|:..|  |...|:.....
Human   258 VAPWKTYPLFFGTA-------IFS------------FEGIGMVLPLENKMKDPRKFPLILYLGMV 303

  Fly   232 ICTFVYISVGFFGYVAFCTHTFSGNILVNLSTSFGSDIIKIGFVLSIAFSFPLVIF-PCRASLYS 295
            |.|.:|||:|..||:.|..: ..|:|.:||...:....:|:.:.:.|.|::.|..: |....:..
Human   304 IVTILYISLGCLGYLQFGAN-IQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPF 367

  Fly   296 LLYRKGHTESSSYIPEQRFRFITIFIVVFSLC----VALVIPSVELIIGLVGSTIGVAICIMFPA 356
            .:.|         .||.....:.:|:....:|    :|::||.::|:|.||||....|:.::.|.
Human   368 FVSR---------APEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPP 423

  Fly   357 SSFRKIIKKESME-RTLAQFVFVS--GFLLMILGTYANLSAIDEKSSGPEF 404
            .........|.|. .|:.:...:|  ||:..::|||..|..:.:.|:.|.|
Human   424 LLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	107/427 (25%)
		SLC5-6-like_sbd	8..390	CDD:294310	106/425 (25%)
		DUF4775	<394..652	CDD:292620	3/11 (27%)
		YukC	<561..660	CDD:295067
SLC36A1	XP_011535882.1	SLC5-6-like_sbd	53..459	CDD:294310	105/424 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810