DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30394 and SLC36A4

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_689526.2	Gene:	SLC36A4 / 120103	HGNCID:	19660	Length:	504	Species:	Homo sapiens

Alignment Length:	489	Identity:	118/489 - (24%)
Similarity:	193/489 - (39%)	Gaps:	133/489 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTS-LLTRRRSFEMLG-- 69
            :|.|....||.|:|.:|...:..||:|..:.||....|:..|.|.|::.| .|..|.....||
Human    65 LMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYS 129

  Fly    70 --------------LHAFGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQI-----IAKIF--- 112
                          |......|:.:|:..::...:|.|..|.|.:.:...|:     .:|:|
Human   130 DTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISN 194

  Fly   113 ALDVADHLHLRSLVMVVVTVVCIVP-------LGMLRNVDSLSAVCTASIGFYVCLILKIVLE-- 168
            :.:.::....|| |.:.:.::|.:|       :..|:|:..||.:...|:...:.:|.:.|:.
Human   195 STNSSNPCERRS-VDLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNM 258

  Fly   169 AQPH---ITANDWTEKVLYWEPA-----GVLQCLPIFSMALSCQMQLFEVFESINNQSLDKLNGI 225
            ..||   |.|. |.:..|::..|     |:...||     |..||:..:.|.    |:|:...||
Human   259 PDPHNLPIVAG-WKKYPLFFGTAVFAFEGIGVVLP-----LENQMKESKRFP----QALNIGMGI 313

  Fly   226 VRNATWICTFVYISVGFFGYVAFCTH-TFSGNILVNLST------------SFGSDIIKIGFVLS 277
            |       |.:|:::...||:  |.| ...|:|.:||..            |||     |....|
Human   314 V-------TTLYVTLATLGYM--CFHDEIKGSITLNLPQDVWLYQSVKILYSFG-----IFVTYS 364

  Fly   278 IAFSFPL-VIFPCRASLYSLLYRKGHTESSSYIPEQRFRF-ITIFIVVFSLCVALVIPSVELIIG 340
            |.|..|. :|.|...|       |.||:.     :|...| |..|:|..:...|::||.::::|.
Human   365 IQFYVPAEIIIPGITS-------KFHTKW-----KQICEFGIRSFLVSITCAGAILIPRLDIVIS 417

  Fly   341 LVGSTIGVAICIMFP----ASSFRK-------IIKKESMERTLAQFVFVSGFLLMILGTYANLSA 394
            .||:.....:.::.|    ..:|.|       ::|..|:     .|..|.|||   ||||..:..
Human   418 FVGAVSSSTLALILPPLVEILTFSKEHYNIWMVLKNISI-----AFTGVVGFL---LGTYITVEE 474

  Fly   395 IDEKSSGPEFDMVAIGTPLYPDGQVPAVVGELPK 428
            |                 :||   .|.||...|:
Human   475 I-----------------IYP---TPKVVAGTPQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	111/451 (25%)
		SLC5-6-like_sbd	8..390	CDD:294310	110/449 (24%)
		DUF4775	<394..652	CDD:292620	7/35 (20%)
		YukC	<561..660	CDD:295067
SLC36A4	NP_689526.2	SLC5-6-like_sbd	58..476	CDD:294310	112/472 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810