DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30394 and slc38a10

DIOPT Version :9

Sequence 1:	NP_611578.1	Gene:	CG30394 / 37437	FlyBaseID:	FBgn0050394	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_004916417.2	Gene:	slc38a10 / 100488480	XenbaseID:	XB-GENE-958197	Length:	1066	Species:	Xenopus tropicalis

Alignment Length:	939	Identity:	251/939 - (26%)
Similarity:	436/939 - (46%)	Gaps:	226/939 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VMTLANSIIGVGILAMPFCFQKCGILLSIVLLVLSNGITRVCCHYLIKTSLLTRRRSFEMLGLHA 72
            :|.:.|||:||.:|.|||||::|||:|..:||:|...:|...|.:|:|::.:::||::..|..:|
Frog     9 IMNIVNSIVGVSVLTMPFCFKQCGIILGTLLLMLCAWMTHQSCMFLVKSASVSKRRTYAGLAFNA 73

  Fly    73 FGTSGKLLVELCIIGYLIGTCITYFVVVGDLGPQIIAKIFALDVADHLHLRSLVMVVVTVVCIVP 137
            :|.:||::||..:||.::||||.::||:||||....|::..|.|.:  ..|..::..|::..::|
Frog    74 YGKAGKMMVETSMIGLMLGTCIAFYVVIGDLGSSFFARLLGLQVTE--GFRVFLLFSVSLCIVLP 136

  Fly   138 LGMLRN----VDSLSAVCTASIGFYVCLILKIVLEAQPH-ITANDWTEKVLY--WEPAGVLQCLP 195
            |.:.||    :.|.||:   ::.||...:..|||.:..| :.:..|.:.|.|  ||  ||.:|:|
Frog   137 LSLQRNMMASIQSFSAM---ALMFYTVFMFVIVLSSFKHGLFSGQWLKHVSYVRWE--GVFRCIP 196

  Fly   196 IFSMALSCQMQLFEVFESINNQSLDKLNGIVRNATWICTFVYISVGFFGYVAFCTHTFSGNILVN 260
            |:.|:.:||.|:...::|::..|:..::.|...:..:.|..||:|||||||:| |.:.:||:|||
Frog   197 IYGMSFACQSQVLPTYDSLDEPSVKIMSSIFALSLNVVTTFYITVGFFGYVSF-TESIAGNVLVN 260

  Fly   261 LSTSFGSDIIKIGFVLSIAFSFPLVIFPCRASLYSLLY----RKGHTESSSYIPEQRFRFITIFI 321
            ..::..:::|::||::|:|..||::|.|||.:|.:||:    :.|...:..|:|..||:.:|:.:
Frog   261 FPSNLVTEMIRVGFMMSVAVGFPMMILPCRQALNTLLFEQQQKDGTFTAGGYMPPLRFKVLTLVV 325

  Fly   322 VVFSLCVALVIPSVELIIGLVGSTIGVAICIMFPASSFRKIIKKESMERTLAQFVFVSGFLLMIL 386
            |..::...::||:||.|:||.|:|:|..||::.||..::||.||    ...:||:...|.:::::
Frog   326 VFGTMLGGILIPNVETILGLTGATMGSLICLICPALIYKKIHKK----GLTSQFILGVGLVILVI 386

  Fly   387 GTYANLSAIDEKSSGPEFDMVAIGTPLYPDGQVPAVVGELPKHLAKESIDSEKNLLLKKLDVQNP 451
            .|||.|:..:|:...||.                         |.:|.:...|:.|
Frog   387 STYATLTVTEEQKIKPEV-------------------------LEREDLKEGKSDL--------- 417

  Fly   452 DKLKQTVEDKVVDMPEVVQSASS--DNPPLPPLPIDEVHVV-PIDSKNSETDIKKLPVEAVEANP 513
                :.::.::.|...:|:....  |.|.|||..::|..:. ||:....|.|.||.  |.|:.:.
Frog   418 ----EEIQSQISDEKPIVEKPGDDRDKPKLPPKKLEEEQIKGPIEVPQKEDDTKKR--EEVQLDR 476

  Fly   514 PEAKPLDVNLTVDKPKNNPPAVAASLPDKPKIGSSLLSASNTIDGAAI-KKEEDVAAEEQKESKA 577
            |:..  |:.:.|.:...:.|.|       |:            |..|: :|::....||:|||..
Frog   477 PDQG--DIAVPVGEAHRHEPPV-------PR------------DEVAVDEKKDQEEREEKKESVV 520

  Fly   578 NADELLKTQK-ELKETKKLLAKTVGELNEELAK--------------KNSFNQPPLELQKDEP-- 625
            :.|:..|..| |:|...:...|...|.|..:.:              |.....||....|::|
Frog   521 DNDDTEKKDKQEIKVENEQEIKDQAEANNRIKEPVPQNPPQEVDDPNKQQLVNPPTPRVKEQPPF 585

  Fly   626 --LDTGAKFAE---EPKK-AEI-------------KLKESQPVADEKKER--------------- 656
              |:...|..|   |||| |||             |..|:.|:.|||.|:
Frog   586 KDLEGIGKDVEVPVEPKKNAEIAGEKNNNDFANPGKAVENPPIKDEKNEQVPGDPGKEQHEVQNG 650

  Fly   657 ------------RR------------QASLMDILTE----NTHLRDE--------KEAHAGVF-- 683
                        ||            .|.|:.::.|    ...|.|:        ||.|..:.
Frog   651 EPKAGDNQAAELRRLAEQAGKAELLDHAFLLQVIKEQQVQQKRLLDQQEKLLEVIKEQHMEIHQQ 715

  Fly   684 ----EPLSYKTGELLRNS--TVDKEALIKRLPIPLALMVNSTQPKSSNDSEIKKPNLEDNV---- 738
                |......|.:..|:  .:..||::.:.|:....:.|:.|.|::    |:||.:|..|
Frog   716 KEDEEQQDKPEGNIGENNKEELKAEAIVVQKPLDGDKVENAGQLKAN----IEKPAVEKPVVMED 776

  Fly   739 --------EAIRRELLNLRSSADATEQPPARVKREASNDENCLRQPKLDEVNNNVAAAALSLNME 795
                    |.::..:.:::.:.|..|.|...|                :||.     .|:|...|
Frog   777 KQQNSVLKEEVKGNVPDVKKNEDKIEAPKIIV----------------EEVK-----VAVSTGKE 820

  Fly   796 SIGRDLKSIKDD-----DVEIVTENESYQ 819
            |.....:||:::     |:|| .:|...|
Frog   821 SQDAKKQSIQENPNHHLDLEI-NDNHKQQ 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30394	NP_611578.1	SdaC	8..392	CDD:223884	141/394 (36%)
		SLC5-6-like_sbd	8..390	CDD:294310	139/392 (35%)
		DUF4775	<394..652	CDD:292620	63/297 (21%)
		YukC	<561..660	CDD:295067	38/174 (22%)
slc38a10	XP_004916417.2	SLC5-6-like_sbd	3..393	CDD:382020	141/395 (36%)
slc38a10	XP_004916417.2	PTZ00121	<396..1013	CDD:173412	109/540 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2890
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006930
OrthoInspector	1	1.000	-	-		oto104349
Panther	1	1.100	-	-	LDO	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060