DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9485 and GDB1

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	NP_015510.1	Gene:	GDB1 / 856314	SGDID:	S000006388	Length:	1536	Species:	Saccharomyces cerevisiae

Alignment Length:	1630	Identity:	559/1630 - (34%)
Similarity:	838/1630 - (51%)	Gaps:	240/1630 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 IPISEGQDAEHILYRLKRGSKLSVHPDASLLGRKIVLYTNYPAE-GQKFVRTEYRVLGWQLSNGK 163
            ||:.:....:..||.:    ||.|.. .|.:.|..:::||.|.: ...|.|.::
Yeast    31 IPLPKDAPKDQPLYTV----KLLVSA-GSPVARDGLVWTNCPPDHNTPFKRDKF----------- 79

  Fly   164 QITSVMHPEAHVVDTDIRSQVELNM--SGTYHFYFRYLERPDTGCSGADGALYVQVEPTLHVGPP 226
             ...::|...|..|.     ::||:  .|:|.||..:  |.|..........|....|.|::.
Yeast    80 -YKKIIHSSFHEDDC-----IDLNVYAPGSYCFYLSF--RNDNEKLETTRKYYFVALPMLYIN-- 134

  Fly   227 GAQKTIPLDSVRCQTVLAKLLGPLDTWEPKLRVAKEAGYNVIHFTPIQELGGSRSCYSLRDQLKV 291
              .:.:||:|:..|:|::|.||  ..|||.|.......||::||||:||.|.|.|.||:.|||:.
Yeast   135 --DQFLPLNSIALQSVVSKWLG--SDWEPILSKIAAKNYNMVHFTPLQERGESNSPYSIYDQLQF 195

  Fly   292 N-SHFAPQKGGKISFEDVEKVIKKCRQEWGVASICDIVLNHTANESDWLLQHPDATYSCATCPYL 355
            : .||.       |.|||:.:::...::..:.|:.|||.|||||.|.||::||:|.|:..|.|:|
Yeast   196 DQEHFK-------SPEDVKNLVEHIHRDLNMLSLTDIVFNHTANNSPWLVEHPEAGYNHITAPHL 253

  Fly   356 RPAFLLD---ATFAQCGADIAEGSLEHVGVPAVIEQECHLEALKYQLHTSYMSKVNIHELYQCDV 417
            ..|..||   ..|::        :|:..|.|..::....|..:...:....:..:.:.|.|..:|
Yeast   254 ISAIELDQELLNFSR--------NLKSWGYPTELKNIEDLFKIMDGIKVHVLGSLKLWEYYAVNV 310

  Fly   418 MKYVNEFMSQVRTREP-----PKNVANECRFQEIQL-------IQDPQY----RRLASTIN---F 463
            ...:.:..:.......     |:|: .:.....::|       :.:|.:    .|.::.||   |
Yeast   311 QTALRDIKAHWNDESNESYSFPENI-KDISSDFVKLASFVKDNVTEPNFGTLGERNSNRINVPKF 374

  Fly   464 ELALEIFNAFHGDCFDEESRFRKCAETLRRHLDALNDRVRCEVQGYINYAIDNVLAGVRYERVQG 528
            ...|::.|  .|...|.||..    .|.:..|:.:|..:..|....::..::.:...::|.|:..
Yeast   375 IQLLKLIN--DGGSDDSESSL----ATAQNILNEVNLPLYREYDDDVSEILEQLFNRIKYLRLDD 433

  Fly   529 DGPRVKEISEKHSVFMVYFTHTGTQGKSLTEIEADMYTKAGEFFMAHNGWVMGYSDPLRDFAEEQ 593
            .||:...::....:...|||.  .:||..|           ::.:|:|||:.. .:||.|||.:
Yeast   434 GGPKQGPVTVDVPLTEPYFTR--FKGKDGT-----------DYALANNGWIWN-GNPLVDFASQ- 483

  Fly   594 PGRANVYLKRELISWGDSVKLRFGRRPEDSPYLWQHMTEYVQTTARIFDGVRLDNCHSTPLHVAE 658
              .:..||:||:|.|||.||||:|:.||||||||:.|::|::..|:||||.|:|||||||:||.|
Yeast   484 --NSRAYLRREVIVWGDCVKLRYGKSPEDSPYLWERMSKYIEMNAKIFDGFRIDNCHSTPIHVGE 546

  Fly   659 YLLDAARKINPELYVVAELFTNSDYTDNVFVNRLGITSLIREALSAWDSHEQGRLVYRYGGVPVG 723
            |.||.|||.||.||||||||:.|:..|.:||.||||:||||||:.||...|..|||:::||.|:|
Yeast   547 YFLDLARKYNPNLYVVAELFSGSETLDCLFVERLGISSLIREAMQAWSEEELSRLVHKHGGRPIG 611

  Fly   724 GFQ----------ANSSRHE------------------------ATSVAHALFLDLTHDNPSPVE 754
            .::          |:.:.:|                        ..:..||||:|.||||.:|.|
Yeast   612 SYKFVPMDDFSYPADINLNEEHCFNDSNDNSIRCVSEIMIPKILTATPPHALFMDCTHDNETPFE 676

  Fly   755 KRSVYDLLPSAALVSMACCATGSNRGYDELVPHHIHVVDEERTYQEWGKGVDSKSGIMGAKRALN 819
            ||:|.|.||:||||::...|.||..||||:.||.:::|.|:|.|...........||...|..||
Yeast   677 KRTVEDTLPNAALVALCSSAIGSVYGYDEIFPHLLNLVTEKRHYDISTPTGSPSIGITKVKATLN 741

  Fly   820 LLHGQLAEEGF----SQVYVDQMDPNVVAVTRHSPITHQSVILVAHTAFGYPSPNAGPTGIRP-- 878
            .:...:.|:.:    |:::|.... ..:...|....:.:...|:|...|   |.|..|....|
Yeast   742 SIRTSIGEKAYDIEDSEMHVHHQG-QYITFHRMDVKSGKGWYLIARMKF---SDNDDPNETLPPV 802

  Fly   879 --------LRF----EGVLDEIILEASLTMQSDKPFDRPAPFK-KDPNVINGFTQFQLNLQEHIP 930
                    |||    |.|.|||        .:|..|.:..|.| |:   :.||
Yeast   803 VLNQSTCSLRFSYALERVGDEI--------PNDDKFIKGIPTKLKE---LEGF------------ 844

  Fly   931 LAKSTVFQTQAYSDGNN-TELNFANLRPGTVVAIRVSMHPGPRTSFDKLQKISAALRIGSGEEYS 994
                    ..:|.|... :.:...|..|...:||..:...|...|.|...: |.||:
Yeast   845 --------DISYDDSKKISTIKLPNEFPQGSIAIFETQQNGVDESLDHFIR-SGALK-------- 892

  Fly   995 QLQAIVSKLDLVALSGALFSCDDEERDLGKG-GTAYDIPNFGKIVYCGLQGFISLLTEISPKNDL 1058
                ..|.|.|.:::..|:..:.||.|:..| |.||.||||||.|||||||::|:|.:|...|||
Yeast   893 ----ATSSLTLESINSVLYRSEPEEYDVSAGEGGAYIIPNFGKPVYCGLQGWVSVLRKIVFYNDL 953

  Fly  1059 GHPLCNNLRDGNWMMDYISDRLTSYED---LKPLSAWFKATFEPLKNIPRYLIPCYFDAIVSGVY 1120
            .|||..|||:|:|.:||...||..|.|   :..:..|.::.|:.:|.:|.||:|.||..|:..:|
Yeast   954 AHPLSANLRNGHWALDYTISRLNYYSDEAGINEVQNWLRSRFDRVKKLPSYLVPSYFALIIGILY 1018

  Fly  1121 NVLINQVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSAN-LPGFSPALSPPKPPKQCVTLSAGL 1184
            .....:..:||...|.....|.|||:::::|.:|..||.: |||           :...:::|||
Yeast  1019 GCCRLKAIQLMSRNIGKSTLFVQSLSMTSIQMVSRMKSTSILPG-----------ENVPSMAAGL 1072

  Fly  1185 PHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFIIIGFGQTLRHGLIPNLLDSGSKPRFNCRDA 1249
            ||||..||||||||.||:|||.:..|||::||:..|:.|.:||:|||||||||:|..||:|.|||
Yeast  1073 PHFSVNYMRCWGRDVFISLRGMLLTTGRFDEAKAHILAFAKTLKHGLIPNLLDAGRNPRYNARDA 1137

  Fly  1250 IWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDA--DAHAPGAF--DQLLFDVMQEALQVHFQG 1310
            .|:::..::.||...|.|.:||:::|:|.||.||.  ....|.||  ...|.:::.|.|..|.:|
Yeast  1138 AWFFLQAVQDYVYIVPDGEKILQEQVTRRFPLDDTYIPVDDPRAFSYSSTLEEIIYEILSRHAKG 1202

  Fly  1311 LQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNNFNCGTWMDKMGSSQKAGNKGRPSTPR 1375
            :::||.|||..:|..|.|:|||.:|.:...||.:.||:.:||||||||||.|:|||:.|.|.|||
Yeast  1203 IKFREANAGPNLDRVMTDKGFNVEIHVDWSTGLIHGGSQYNCGTWMDKMGESEKAGSVGIPGTPR 1267

  Fly  1376 DGSAVELVGLQYAVLRFMQSLAEKEVIPYTGVERKGPSGEVTKWSYKEWADRIKNNFDKYFFVSE 1440
            ||:|:|:.||..:.|||:..|..|.:..::.||.: ..|.:   .:.||...:::||:|.::|.|
Yeast  1268 DGAAIEINGLLKSALRFVIELKNKGLFKFSDVETQ-DGGRI---DFTEWNQLLQDNFEKRYYVPE 1328

  Fly  1441 SETCSV---------ANKKLIYKDSYGATQSWTDYQLRCNFPITLTVAPDLCNPQNAWRALERAK 1496
            ..:...         .|::.||:|.|.:.:.:.|||||.||.|.:||||:|..|::|.:|:..|.
Yeast  1329 DPSQDADYDVSAKLGVNRRGIYRDLYKSGKPYEDYQLRPNFAIAMTVAPELFVPEHAIKAITIAD 1393

  Fly  1497 KYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQGPEWVWPIGFYLRARLIFAKKCG 1561
            :.|.||:||:|:||.|:|||..|:|..||.|...:.|.||||||||||..|::|||...|..|..
Yeast  1394 EVLRGPVGMRTLDPSDYNYRPYYNNGEDSDDFATSKGRNYHQGPEWVWLYGYFLRAFHHFHFKTS 1458

  Fly  1562 HLDETIA----------ETWAILRAHLRELQTSHWRGLPELTNDNGSYCGDSCRTQAWSVAAILE 1616
            ...:..|          :.:..|:.|.:.:..|.|.||.||||.:|..|.||..|||||.|.:|:
Yeast  1459 PRCQNAAKEKPSSYLYQQLYYRLKGHRKWIFESVWAGLTELTNKDGEVCNDSSPTQAWSSACLLD 1523

  Fly  1617 VLYDL 1621
            :.|||
Yeast  1524 LFYDL 1528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	555/1616 (34%)
		hGDE_N	121..224	CDD:291371	23/105 (22%)
		AmyAc_Glg_debranch_2	212..704	CDD:200466	173/514 (34%)
		hGDE_central	810..1080	CDD:291374	83/290 (29%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	22/76 (29%)
		GDE_C	1147..1616	CDD:283786	206/492 (42%)
GDB1	NP_015510.1	glyc_debranch	26..1528	CDD:273673	557/1628 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343686
Domainoid	1	1.000	393	1.000	Domainoid score	I93
eggNOG	1	0.900	-	-		E1_COG3408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H536
Inparanoid	1	1.050	830	1.000	Inparanoid score	I54
Isobase	1	0.950	-	0	Normalized mean entropy	S2301
OMA	1	1.010	-	-		QHG54289
OrthoFinder	1	1.000	-	-		FOG0006187
OrthoInspector	1	1.000	-	-		oto100098
orthoMCL	1	0.900	-	-		OOG6_103063
Panther	1	1.100	-	-	LDO	PTHR10569
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2125
SonicParanoid	1	1.000	-	-		X3932
TreeFam	1	0.960	-	-
	16	15.740