DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9485 and agl

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	XP_031756872.1	Gene:	agl / 780065	XenbaseID:	XB-GENE-1001429	Length:	1532	Species:	Xenopus tropicalis

Alignment Length:	1573	Identity:	724/1573 - (46%)
Similarity:	1005/1573 - (63%)	Gaps:	92/1573 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SHSIPISEGQDAEHI---LYRLKRGSKLSVHPDASLLGRKIVLYTNYPAEGQKFVRTEYRVLGWQ 158
            |..:.:.:..|.|.:   |:||::|.:|......:|.|:.:.:|:|||..|..:.|..:..|.|.
Frog     4 SKQVRVLQLNDMEKLDKRLFRLEQGFELQFRLGPTLQGKDVTVYSNYPPPGAVYDRQTFHPLQWH 68

  Fly   159 LSNGKQITSVMHPEAHVVDTDIRSQVELNMSGTYHFYFRYLERPDTGCSGADGALYVQVEPTLHV 223
            ...|::           .|:|...:::|.::|::.::|...::       .:|..|:.|:|.|.|
Frog    69 NPTGRE-----------EDSDKFCKLDLKIAGSFQYHFLQGDQ-------KNGEGYIVVDPVLRV 115

  Fly   224 GPPGAQKTIPLDSVRCQTVLAKLLGPLDTWEPKLRVAKEAGYNVIHFTPIQELGGSRSCYSLRDQ 288
            |  ...:.:|||.:..||.|:|.|||||.||.:|:||||||||:|||||:|.||.|||||||.||
Frog   116 G--ADNRALPLDCITLQTYLSKCLGPLDEWEDRLKVAKEAGYNMIHFTPLQTLGESRSCYSLADQ 178

  Fly   289 LKVNSHFAPQKGGKI-SFEDVEKVIKKCRQEWGVASICDIVLNHTANESDWLLQHPDATYSCATC 352
            |::|..|:  :.||: .::||.|:::|.|:||.:.||.|:|.||||..|.|:.|||:..|:....
Frog   179 LQLNPDFS--RPGKVYGWDDVGKLVEKMRKEWNMLSITDVVYNHTAANSKWIQQHPECGYNLVNS 241

  Fly   353 PYLRPAFLLDATFAQCGADIAEGSLEHVGVPAVIEQECHLEALKYQLHTSYMSKVNIHELYQCDV 417
            |:|:||:|||........|.|||.....|:||:|:.:..|.:::..:......::.:.|.||.:|
Frog   242 PHLKPAWLLDRALWHLTCDAAEGKYAAKGLPALIKTDQQLNSIRGIVWEEIYPRIKLWEFYQVEV 306

  Fly   418 MKYVNEFMSQVRTREPPKNVANECRFQEIQLIQDPQYRRLASTINFELALEIFNAFHGDCFDEES 482
            .|.|.:|.:.:.:....|  .|:...:.:.:||||:|:|...:::.:.||..|.. |.   :..|
Frog   307 DKAVKQFRALLTSGAQKK--GNKSDPKHLMIIQDPEYKRFGCSVDMDTALNTFIP-HS---NGPS 365

  Fly   483 RFRKCAETLRRHLDALNDRVRCEVQGYINYAIDNVLAGVRYERVQGDGPRVKEISEKHSVFMVYF 547
            ...:|....|:.|:.||.....::..:...|::.:|..:.|||:.|.||::..|::|..:...||
Frog   366 AIEECCTWFRKRLEELNAEKHRQMNFHHEQAVNCILGTMTYERLAGQGPKLGPITKKDPIVTRYF 430

  Fly   548 THTGTQGKSLTEIEADMY--TKAGEFFMAHNGWVMGYSDPLRDFAEEQPGRANVYLKRELISWGD 610
            |.. .:..||:|.|:.|:  .||. :|:|||||||| .||||:||...   :|||::||||.|||
Frog   431 TFP-FKDMSLSEEESMMHQPDKAC-YFLAHNGWVMG-DDPLRNFAGPD---SNVYVRRELICWGD 489

  Fly   611 SVKLRFGRRPEDSPYLWQHMTEYVQTTARIFDGVRLDNCHSTPLHVAEYLLDAARKINPELYVVA 675
            |||||:|.:|.|.||||:||.:|.:.||:.|.|||||||||||:||||||||.|||:.|:|||||
Frog   490 SVKLRYGDKPSDCPYLWEHMKKYTEITAKHFHGVRLDNCHSTPIHVAEYLLDVARKVRPDLYVVA 554

  Fly   676 ELFTNSDYTDNVFVNRLGITSLIREALSAWDSHEQGRLVYRYGGVPVGGFQANSSRHEATSVAHA 740
            ||||.|:..|||||.||||.||||||:||::|||:||||||:||.|||.|...|.|....|:|||
Frog   555 ELFTGSEELDNVFVTRLGINSLIREAMSAYNSHEEGRLVYRFGGEPVGSFVQPSLRPLVPSIAHA 619

  Fly   741 LFLDLTHDNPSPVEKRSVYDLLPSAALVSMACCATGSNRGYDELVPHHIHVVDEERTYQEWG--- 802
            ||:|:||||.||:..||.||.|||:|:||||||||||.|||||||||.|.||.|||.|.:|.
Frog   620 LFMDVTHDNESPITHRSAYDSLPSSAIVSMACCATGSTRGYDELVPHQISVVSEERFYTKWNPKM 684

  Fly   803 -----KGVDSKSGIMGAKRALNLLHGQLAEEGFSQVYVDQMDPNVVAVTRHSPITHQSVILVAHT 862
                 :.|:.:|||:..|||||.||.:||..||.||||||:|.::||||||.|.|||||:.|:.|
Frog   685 AAPIPRDVNGQSGIIAGKRALNKLHQELAARGFLQVYVDQVDEDIVAVTRHCPHTHQSVVAVSRT 749

  Fly   863 AFGYPSPNAGPTGIRPLRFEGVLDEIILEASLTMQSDKPFDRPA-PFKKDPNVINGFTQFQLNLQ 926
            ||..|..:.....:..:...|.::|:||||       :..:|.| |:.:|...|||..|:.:.::
Frog   750 AFRDPKNSFYSKEVPQMCIPGKIEEVILEA-------RTVERKAEPYSQDEKFINGLPQYTVEIR 807

  Fly   927 EHIPLAKSTVF-QTQAYSDGNN---TELNFANLRPGTVVAIRVSMHPGPRTSFDKLQK--ISAAL 985
            |||.|.:|.:. |....:.|.|   .|::|.||.||:|:..|||:.|..:.|...|:.  |....
Frog   808 EHIQLKESKIVKQAGITTKGPNEFVQEIDFENLTPGSVIIFRVSLDPKAQESVGILRSHLIQFTP 872

  Fly   986 RIGSG-----EEYSQLQ----AIVSKLDLVALSGALFSCDDEERDLGKGGTAYDIPNFGKIVYCG 1041
            ...||     :.:..|:    :|.:||.|..|:..|:.||.||::  .||..|:|||:..:.|.|
Frog   873 HFTSGSLPDDQAHPILKVPFASIAAKLSLADLNQVLYRCDSEEQE--DGGGCYNIPNWTPLKYAG 935

  Fly  1042 LQGFISLLTEISPKNDLGHPLCNNLRDGNWMMDYISDRLTSY-EDLKPLSAWFKATFEPLKNIPR 1105
            |||.||::.:|.||||||||.|:|||.|:||:||:|:||.:. .....:..||:|.|..||.|||
Frog   936 LQGLISVMVDIRPKNDLGHPFCDNLRCGDWMIDYVSNRLIARGGPCAEVGKWFQAMFSYLKQIPR 1000

  Fly  1106 YLIPCYFDAIVSGVYNVLINQVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSANLPGFSPAL-- 1168
            ||||||||||:.|.|..|::...:.|..|::||.:..:.|||.::|...|.:...||..||:|
Frog  1001 YLIPCYFDAILVGAYTTLLDAAWKQMSSFVQNGSTLIKHLALGSVQMCGVGRFPALPVLSPSLQD 1065

  Fly  1169 ------SPPKPPKQCV-TLSAGLPHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFIIIGFGQT 1226
                  |..:..:||. :|:|||||||:|..|||||||||:|||.:.:||.|.|||.||:.|..|
Frog  1066 VPYRLNSITQEKEQCCPSLAAGLPHFSSGIFRCWGRDTFISLRGLLLITGSYLEARNIILAFAGT 1130

  Fly  1227 LRHGLIPNLLDSGSKPRFNCRDAIWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDADAHAPGA 1291
            ||||||||||..|:..|:|||||:|||:.||:.|....|.|:.||:..|||::|.||:.....|.
Frog  1131 LRHGLIPNLLGQGTYARYNCRDAVWWWLQCIQDYCITVPNGSAILQCPVSRMYPTDDSPTQPAGQ 1195

  Fly  1292 FDQLLFDVMQEALQVHFQGLQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNNFNCGTWM 1356
            .||.|::|:|||||.|..|:.:||||||.:||.:|.|:|||...|:..|||||||||..||||||
Frog  1196 VDQPLYEVIQEALQRHALGINFRERNAGPQIDRNMRDEGFNIVAGVDLETGFVFGGNRLNCGTWM 1260

  Fly  1357 DKMGSSQKAGNKGRPSTPRDGSAVELVGLQYAVLRFMQSLAEKEVIPYTGVERKGPSGEVTKWSY 1421
            ||||.|::|.:||.|:|||||||||:|||..:.:|::|.|:||::.||.||.......||| .::
Frog  1261 DKMGESERARSKGIPATPRDGSAVEIVGLCKSTVRWLQDLSEKKLYPYKGVTVLRDGREVT-LTF 1324

  Fly  1422 KEWADRIKNNFDKYFFVSES------ETCSVANKKLIYKDSYGATQSWTDYQLRCNFPITLTVAP 1480
            .||..||::||:|.|||||:      :...:.:|:.|||||:||:..|.|||||.|||:.:.|||
Frog  1325 SEWNQRIQDNFEKKFFVSENISDPNEQRPDLVHKRGIYKDSFGASSPWCDYQLRPNFPVAMVVAP 1389

  Fly  1481 DLCNPQNAWRALERAKKYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQGPEWVWP 1545
            :|..|:|||:|||..:|.|:|||||||:||:|..|...|||:.|:.:..::.|.||||||||:||
Frog  1390 ELFTPKNAWKALEITEKKLMGPLGMKTLDPDDMVYCGVYDNALDNDNYNLSKGFNYHQGPEWMWP 1454

  Fly  1546 IGFYLRARLIFAKKCGH--LDETIAETWAILRAHLRELQTSHWRGLPELTNDNGSYCGDSCRTQA 1608
            ||::|||:|.|||....  ..:|:.....:|..|...|:.|.|:|||||||:||.||..||.|||
Frog  1455 IGYFLRAKLHFAKLMDRESYQKTVVLVKNVLSRHYTHLERSSWKGLPELTNENGQYCPFSCETQA 1519

  Fly  1609 WSVAAILEVLYDL 1621
            ||::.||||||||
Frog  1520 WSISVILEVLYDL 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	719/1553 (46%)
		hGDE_N	121..224	CDD:291371	22/102 (22%)
		AmyAc_Glg_debranch_2	212..704	CDD:200466	224/494 (45%)
		hGDE_central	810..1080	CDD:291374	118/285 (41%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	32/74 (43%)
		GDE_C	1147..1616	CDD:283786	251/485 (52%)
agl	XP_031756872.1	glyc_debranch	22..1532	CDD:273673	719/1553 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	509	1.000	Domainoid score	I327
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H536
Inparanoid	1	1.050	1345	1.000	Inparanoid score	I141
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31743at33208
OrthoFinder	1	1.000	-	-		FOG0006187
OrthoInspector	1	1.000	-	-		oto104891
Panther	1	1.100	-	-	LDO	PTHR10569
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160