DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9485 and agla

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	XP_005163674.1	Gene:	agla / 567798	ZFINID:	ZDB-GENE-071004-6	Length:	1533	Species:	Danio rerio

Alignment Length:	1576	Identity:	732/1576 - (46%)
Similarity:	993/1576 - (63%)	Gaps:	109/1576 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ISEGQDAEHILYRLKRGSKLSVHPDASLLGRKIVLYTNYPAEGQKFVRTEYRVLGWQLSNGKQIT 166
            :::.:..:..|:||.:|.:|......:|.|:.:.:|||||.||::|.|.::..|.|
Zfish    11 LNDMEKLDRTLFRLDQGFELQFRLGPTLQGKHVRVYTNYPTEGERFDRQKFHALDW--------- 66

  Fly   167 SVMHPEAHVVDTDIRSQVELNMSGTYHFYFRYLERPDTGCSGADGALYVQVEPTLHVGPPGAQKT 231
              ::|.|...|:|....::|.:||:|.:||.:      |.....|..|:.|:|.|.||  .....
Zfish    67 --INPTAREDDSDKFCTLDLKISGSYQYYFGH------GGDEKSGGGYIVVDPVLRVG--ADNHV 121

  Fly   232 IPLDSVRCQTVLAKLLGPLDTWEPKLRVAKEAGYNVIHFTPIQELGGSRSCYSLRDQLKVNSHFA 296
            :|||.:..||.|:|.|||||.|..:||||||||||:|||||:|.||.|||||||.|||::|..|:
Zfish   122 LPLDCITIQTYLSKCLGPLDEWSDRLRVAKEAGYNMIHFTPLQTLGESRSCYSLADQLELNPDFS 186

  Fly   297 PQKGGKISFEDVEKVIKKCRQEWGVASICDIVLNHTANESDWLLQHPDATYSCATCPYLRPAFLL 361
            | .|...::.|...:::|.:.||.:..|.|:|.||||:.|.|:.:||:..|:....|:|:||::|
Zfish   187 P-SGQTYTWTDAGNLVEKLKNEWNMLCITDVVYNHTASNSKWIKKHPECGYNLVNSPHLKPAWVL 250

  Fly   362 DATFAQCGADIAEGSLEHVGVPAVIEQECHLEALKYQLHTSYMSKVNIHELYQCDVMKYVNEFMS 426
            |.........||:|..|..|:||:|:...||.|::..|......|:.:.|.:|..:...|.:|.:
Zfish   251 DRALWHVTCAIADGKYEDRGLPALIQDHPHLHAIRGVLWQEVFPKIKLWEFFQVKIEALVEQFRA 315

  Fly   427 QVRTREPPKNVANECRFQEIQLIQDPQYRRLASTINFELALEIF--NAFHGDCFDEESRFRKCAE 489
            .:::...|.:...:.: :::::||||||||..:|::...|||:|  |.      :.......|..
Zfish   316 LLQSGAKPDSSKTDGK-KQLKIIQDPQYRRFGNTVDMNTALELFVPNG------NSPGAIEDCCN 373

  Fly   490 TLRRHLDALNDRVRCEVQGYINYAIDNVLAGVRYERVQGDGPRVKEISEKHSVFMVYFTHTGTQG 554
            .|||.|:.||.....||:.:...|.:.:...|.|||:...||::..|:.||.:...|||....:
Zfish   374 WLRRKLEELNGEQFHEVKHHQEQATNCIDGTVSYERLADHGPKLGPITRKHPLVTRYFTFPFEE- 437

  Fly   555 KSLTEIEADM----YTKAGEFFMAHNGWVMGYSDPLRDFAEEQPGRANVYLKRELISWGDSVKLR 615
               |.:|.|:    ..:....|:|||||||| .||||:|||  || :|||::||||.||||||||
Zfish   438 ---TTLEQDLELINQPEKSCHFLAHNGWVMG-DDPLRNFAE--PG-SNVYIRRELICWGDSVKLR 495

  Fly   616 FGRRPEDSPYLWQHMTEYVQTTARIFDGVRLDNCHSTPLHVAEYLLDAARKINPELYVVAELFTN 680
            :|..|||.||||.||.:|.:.||:.|.||||||||||||||||.:|.|||.:.|.|||:|||||.
Zfish   496 YGSGPEDCPYLWAHMQKYTEITAKHFVGVRLDNCHSTPLHVAEAMLAAARSVRPNLYVIAELFTG 560

  Fly   681 SDYTDNVFVNRLGITSLIREALSAWDSHEQGRLVYRYGGVPVGGFQANSSRHEATSVAHALFLDL 745
            |:..|||||||||||||||||:||.||||:|||||||||.|||.|...|.|....|:|||:|||:
Zfish   561 SELIDNVFVNRLGITSLIREAMSAGDSHEEGRLVYRYGGEPVGAFLQPSLRPLVPSIAHAMFLDV 625

  Fly   746 THDNPSPVEKRSVYDLLPSAALVSMACCATGSNRGYDELVPHHIHVVDEERTYQEWG-------- 802
            ||||..|::.|||||.|||:|:||||||||||.|||||||||.|.||.|||.|.:|.
Zfish   626 THDNECPIQIRSVYDSLPSSAIVSMACCATGSTRGYDELVPHQISVVSEERFYTKWSSQAKPSSP 690

  Fly   803 KGVDSKSGIMGAKRALNLLHGQLAEEGFSQVYVDQMDPNVVAVTRHSPITHQSVILVAHTAFGYP 867
            ..|:.::||:..|.|||.||.:||.:|||||:|||:|.::||||||.|.|||||:.|..|||..|
Zfish   691 NEVNLQTGIIAGKLALNRLHQELAAKGFSQVFVDQVDEDIVAVTRHCPSTHQSVVAVCRTAFKNP 755

  Fly   868 SPNAGPTGIRPLRFEGVLDEIILEASLTMQSDKPFDRPAPFKKDPNVINGFTQFQLNLQEHIPLA 932
            ..:.....:.|:...|.::|::|||....:      :...:|||...|||..::.:.::|||.||
Zfish   756 KHHRYTDEVPPMCIPGKIEEVVLEARTVER------QTGTYKKDERSINGMPEYTVEIKEHIQLA 814

  Fly   933 KSTVF-QTQAYSDGNN---TELNFANLRPGTVVAIRVSMHPGPRTSFDKLQKISAALR------- 986
            .|.|. |....|.|.:   .|:.|..|.||:|:|.|||:.|       |.|::...||
Zfish   815 DSKVVRQAGVTSRGRSEYVQEIVFEKLTPGSVIAFRVSLDP-------KSQELVGVLRNHLIQFN 872

  Fly   987 ----IGSGEE-------YSQLQAIVSKLDLVALSGALFSCDDEERDLGKGGTAYDIPNFGKIVYC 1040
                .||..:       .|.|..|:|||.|..::..||.||.||::  .||..|:||.:..:.|.
Zfish   873 PLYKAGSVPDSNTPDILKSPLTQIMSKLTLADMNLLLFRCDSEEKE--DGGGCYNIPGWTPLKYG 935

  Fly  1041 GLQGFISLLTEISPKNDLGHPLCNNLRDGNWMMDYISDRLTSY-EDLKPLSAWFKATFEPLKNIP 1104
            ||||.:|::.||.||||||||.|:|||.|:||:||:|:||.|. ..|..:..||:|.|..||:||
Zfish   936 GLQGLLSVMAEIRPKNDLGHPFCDNLRQGDWMIDYVSNRLVSRGGPLAEVGQWFQAMFAYLKHIP 1000

  Fly  1105 RYLIPCYFDAIVSGVYNVLINQVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSANLPGFSPALS 1169
            |||||||||||:.|.:...::.....|..|:::|.||.:.|||.::|...|.:...||..|||||
Zfish  1001 RYLIPCYFDAILVGAFTTALDATFRQMSSFVQDGSSFVKLLALGSVQMCGVGRFPALPPLSPALS 1065

  Fly  1170 P--------PKPPKQ-CVTLSAGLPHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFIIIGFGQ 1225
            .        .|..:| ||:::|||||||.|..|||||||||||||.:.:|||:.|||.||:.|..
Zfish  1066 DVPYRVNEITKEKEQCCVSMAAGLPHFSAGIFRCWGRDTFIALRGLLLVTGRHLEARNIILAFAG 1130

  Fly  1226 TLRHGLIPNLLDSGSKPRFNCRDAIWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDADAHAPG 1290
            |||||||||||..|...|||||||:|||:.||:.|....|.|.:||:..|||::|.||:.....|
Zfish  1131 TLRHGLIPNLLGEGVGARFNCRDAVWWWLQCIQDYCTMVPNGTDILQCPVSRMYPTDDSKPLTAG 1195

  Fly  1291 AFDQLLFDVMQEALQVHFQGLQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNNFNCGTW 1355
            ..||||::|:.||::.|.||:::||.|||.:||.:|.|:|||.:..::|:||||:|||.||||||
Zfish  1196 TVDQLLYEVIHEAMERHIQGIEFRESNAGPQIDRNMRDEGFNIEAKVNPDTGFVYGGNRFNCGTW 1260

  Fly  1356 MDKMGSSQKAGNKGRPSTPRDGSAVELVGLQYAVLRFMQSLAEKEVIPYTGV--ERKGPSGEVTK 1418
            |||||.|::|.|||.|:|||||||||:|||..:.||::..|.:|.:.||..|  :|.|....|
Zfish  1261 MDKMGESERARNKGIPATPRDGSAVEIVGLCKSTLRWLVELHKKGLFPYNTVKIQRDGKQLSV-- 1323

  Fly  1419 WSYKEWADRIKNNFDKYFFVS------ESETCSVANKKLIYKDSYGATQSWTDYQLRCNFPITLT 1477
             :|.||..:|:.||:|.|:||      ..:...:.:|:.||||||||:..|.|||||.||.|.:.
Zfish  1324 -AYDEWEMKIQKNFEKMFYVSHDPNDPNEKHPELVHKRGIYKDSYGASSPWCDYQLRPNFTIAMV 1387

  Fly  1478 VAPDLCNPQNAWRALERAKKYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQGPEW 1542
            |||:|...::||:||..|::.|||||||||:||:|..|...||||.|:.:..:|.|.||||||||
Zfish  1388 VAPELFTVEHAWKALNMAEEKLLGPLGMKTLDPDDMVYCGVYDNSLDNDNYNLAKGFNYHQGPEW 1452

  Fly  1543 VWPIGFYLRARLIFAKKCGH--LDETIAETWAILRAHLRELQTSHWRGLPELTNDNGSYCGDSCR 1605
            :||||::|||::.||||.|.  .|:|:.....:|..|...::.|.|:|||||||:||.||..||.
Zfish  1453 LWPIGYFLRAKIFFAKKMGKDTYDKTVYLVKNVLSRHNVHMERSSWKGLPELTNENGQYCSFSCE 1517

  Fly  1606 TQAWSVAAILEVLYDL 1621
            |||||:||:||||:||
Zfish  1518 TQAWSLAAVLEVLHDL 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	730/1564 (47%)
		hGDE_N	121..224	CDD:291371	30/102 (29%)
		AmyAc_Glg_debranch_2	212..704	CDD:200466	224/497 (45%)
		hGDE_central	810..1080	CDD:291374	119/291 (41%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	33/74 (45%)
		GDE_C	1147..1616	CDD:283786	252/487 (52%)
agla	XP_005163674.1	glyc_debranch	21..1533	CDD:273673	730/1564 (47%)
		hGDE_N	30..116	CDD:291371	30/102 (29%)
		AmyAc_Glg_debranch_2	105..584	CDD:200466	224/496 (45%)
		hGDE_central	698..975	CDD:291374	119/291 (41%)
		GDE_C	1074..1528	CDD:283786	242/456 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580363
Domainoid	1	1.000	506	1.000	Domainoid score	I321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H536
Inparanoid	1	1.050	1367	1.000	Inparanoid score	I126
OMA	1	1.010	-	-		QHG54289
OrthoDB	1	1.010	-	-		D31743at33208
OrthoFinder	1	1.000	-	-		FOG0006187
OrthoInspector	1	1.000	-	-		otm24674
orthoMCL	1	0.900	-	-		OOG6_103063
Panther	1	1.100	-	-	LDO	PTHR10569
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910