DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9485 and aglb

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	XP_021326034.1	Gene:	aglb / 553352	ZFINID:	ZDB-GENE-050309-54	Length:	954	Species:	Danio rerio

Alignment Length:	974	Identity:	474/974 - (48%)
Similarity:	631/974 - (64%)	Gaps:	74/974 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 LSAWDSHEQGRLVYRYGGVPVGGFQANSSRHEATSVAHALFLDLTHDNPSPVEKRSVYDLLPSAA 766
            :||.:|||:||||||:||.|||.|...:.|....|:|||:|||:||||..|::.||.||.|||:|
Zfish     1 MSAGNSHEEGRLVYRFGGEPVGSFIQPNLRPLEPSIAHAMFLDVTHDNECPIQVRSAYDALPSSA 65

  Fly   767 LVSMACCATGSNRGYDELVPHHIHVVDEERTYQEW--------GKGVDSKSGIMGAKRALNLLHG 823
            :|||||||:||.|||||||||.|.||.|||.|.:|        |:.|:..|||...|.|||.||.
Zfish    66 IVSMACCASGSTRGYDELVPHQISVVKEERLYPKWNPDALPSSGREVNLHSGITAGKLALNKLHQ 130

  Fly   824 QLAEEGFSQVYVDQMDPNVVAVTRHSPITHQSVILVAHTAFGYPSPNAGPTGIRPLRFEGVLDEI 888
            :|||.||:||||||:|.:.||||||.|.|||||:.|..|||..|..:.....:.|:...|.::|:
Zfish   131 ELAENGFTQVYVDQLDEDTVAVTRHCPSTHQSVVTVCRTAFKDPKTHQFRESLAPMYIPGKIEEV 195

  Fly   889 ILEASLTMQSDKPFDRPAPFKKDPNVINGFTQFQLNLQEHIPLAKSTVF-QTQAYSDGNN---TE 949
            ||||....:|.:      .:.||...|||...:.:.::|||.|.:|.:. |..|.:.|.:   .|
Zfish   196 ILEARTVERSAE------SYVKDETFINGLPNYTVEIREHIQLKESQIVKQGDATTKGRSEFVEE 254

  Fly   950 LNFANLRPGTVVAIRVSMHPGPR----------TSFDKL--------QKISAALRIGSGEEYSQL 996
            :.|..|.||:|:|.|||:.|..:          :.|::|        .|::..|:|       .|
Zfish   255 ILFEKLTPGSVIAFRVSLDPNSQKMVGYLRTQLSQFNRLFKSGSLTDSKVAGILKI-------SL 312

  Fly   997 QAIVSKLDLVALSGALFSCDDEERDLGKGGTAYDIPNFGKIVYCGLQGFISLLTEISPKNDLGHP 1061
            :.::|||.|..|:..||.||.||::  .||..|:||::..:.|.|||||:|:|:||.||||||||
Zfish   313 EFLISKLTLAELNVLLFRCDAEEQE--DGGGCYNIPSWMPLKYGGLQGFVSVLSEIRPKNDLGHP 375

  Fly  1062 LCNNLRDGNWMMDYISDRLTSYED-LKPLSAWFKATFEPLKNIPRYLIPCYFDAIVSGVYNVLIN 1125
            .|:|||.|:|::||:|.||.:... |:.:..||||.|..||::||||:|||||||:.|.|...::
Zfish   376 FCDNLRQGDWILDYVSTRLINKGGALREVGKWFKAVFSYLKHLPRYLVPCYFDAIIVGAYATAVD 440

  Fly  1126 QVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSANLPGFSPAL--------SPPKPPKQ-CVTLS 1181
            .|...|..|:.||.:..:.|||.::|...|.:...||..||.|        |..|..:| ||:::
Zfish   441 AVFNQMSSFVLNGSTLVKQLALGSVQMCGVGRVPALPHLSPELEDVPVRVNSATKQEEQCCVSIA 505

  Fly  1182 AGLPHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFIIIGFGQTLRHGLIPNLLDSGSKPRFNC 1246
            |||||||||..|||||||||||||.|.||||:.|||.||:.|..|:|||||||||..|...|:||
Zfish   506 AGLPHFSTGIFRCWGRDTFIALRGLMLLTGRHLEARDIILAFAGTMRHGLIPNLLGQGVAARYNC 570

  Fly  1247 RDAIWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDADAHAPG--AFDQLLFDVMQEALQVHFQ 1309
            |||:|||:.||:.|....|.|.:||...|||::|.||::|.|.|  |.||.|:.::|||:|.|.|
Zfish   571 RDAVWWWLQCIQDYCTIVPIGTDILMCPVSRMYPTDDSEAQALGTVAHDQPLYVLIQEAMQRHMQ 635

  Fly  1310 GLQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNNFNCGTWMDKMGSSQKAGNKGRPSTP 1374
            |:|:||||||.:||.:|..:|||.:..::||||||:|||.|||||||||||.|.||.|||.|:||
Zfish   636 GIQFRERNAGPQIDWNMQHEGFNVEAKVNPETGFVYGGNGFNCGTWMDKMGESDKAHNKGVPATP 700

  Fly  1375 RDGSAVELVGLQYAVLRFMQSLAEKEVIPYTGVE--RKGPSGEVTKWSYKEWADRIKNNFDKYFF 1437
            |||||||:|||..:.:|::..:.|....||:.|:  |.|....:|   ||||..||:.||:::|:
Zfish   701 RDGSAVEIVGLSKSAVRWLMMMNETGHFPYSSVKIHRDGAEQSIT---YKEWNQRIQENFERFFY 762

  Fly  1438 VSE------SETCSVANKKLIYKDSYGATQSWTDYQLRCNFPITLTVAPDLCNPQNAWRALERAK 1496
            ||:      .:...:.:||.|||||:||:..|.|||||.||.|.:.|||:|.:.|.||:|||..:
Zfish   763 VSDDPADPNEQRPDLVHKKCIYKDSHGASSPWCDYQLRPNFTIAMVVAPELFSVQRAWKALEIVE 827

  Fly  1497 KYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQGPEWVWPIGFYLRARLIFAKKCG 1561
            ..|||||||||:||:|..|...|||:.|:.|...|.|.||||||||:|.:|::|||:|.|.:|.|
Zfish   828 TKLLGPLGMKTLDPDDLVYCGVYDNALDNDDYNRAKGFNYHQGPEWIWLVGYFLRAKLYFGRKMG 892

  Fly  1562 HLDETIAETWAILRAHLRELQT----SHWRGLPELTNDNGSYCGDSCRTQAWSVAAILEVLYDL 1621
              .|...::..:::..|..|.|    |.|:|||||||:||.||..||.|||||:|.:||.|:||
Zfish   893 --QEKYNQSVFLVKNVLSRLHTHLERSPWKGLPELTNENGQYCPFSCETQAWSIATVLEALFDL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	472/972 (49%)
		hGDE_N	121..224	CDD:291371
		AmyAc_Glg_debranch_2	212..704	CDD:200466	0/1 (0%)
		hGDE_central	810..1080	CDD:291374	118/291 (41%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	32/74 (43%)
		GDE_C	1147..1616	CDD:283786	254/491 (52%)
aglb	XP_021326034.1	GDE_C	<1..954	CDD:330793	472/972 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580364
Domainoid	1	1.000	506	1.000	Domainoid score	I321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1367	1.000	Inparanoid score	I126
OMA	1	1.010	-	-		QHG54289
OrthoDB	1	1.010	-	-		D31743at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24674
orthoMCL	1	0.900	-	-		OOG6_103063
Panther	1	1.100	-	-	O	PTHR10569
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910