DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9485 and Agl

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	NP_001102034.1	Gene:	Agl / 362029	RGDID:	1306376	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1574	Identity:	735/1574 - (46%)
Similarity:	996/1574 - (63%)	Gaps:	107/1574 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ISEGQDAEHILYRLKRGSKLSVHPDASLLGRKIVLYTNYPAEGQKFVRTEYRVLGWQLSNGKQIT 166
            ::|.:..|..|:||::|.:|......:|.|:.:.:|||||..|:.|.|.::|.|.|:
  Rat    12 LNEMEKLEKTLFRLEQGFELQFRLGPTLQGKAVTVYTNYPFPGEAFNREKFRSLDWE-------- 68

  Fly   167 SVMHPEAHVVDTDIRSQVELNMSGTYHFYFRYLERPDTGCSGADGALYVQVEPTLHVGPPGAQKT 231
               :|.....|:|...:|.|..||::.:||  |:..:....|     |:.|:|.|.||  .....
  Rat    69 ---NPTEREDDSDKYCKVHLQQSGSFQYYF--LQGQEKSGGG-----YIVVDPILRVG--ADNHV 121

  Fly   232 IPLDSVRCQTVLAKLLGPLDTWEPKLRVAKEAGYNVIHFTPIQELGGSRSCYSLRDQLKVNSHFA 296
            :|||.|..||.|||.|||.|.||.:||||||:|||:|||||:|.||.|||||||.|||::|..|:
  Rat   122 LPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQALGLSRSCYSLADQLELNPDFS 186

  Fly   297 -PQKGGKISFEDVEKVIKKCRQEWGVASICDIVLNHTANESDWLLQHPDATYSCATCPYLRPAFL 360
             |.:  :.:::||.::::|.::||.:..|.|:|.||||..|.|:.:||::.|:....|:|:||::
  Rat   187 RPNR--RYTWDDVGQLVEKLKREWNILCITDVVYNHTAANSKWIHEHPESAYNLVNSPHLKPAWV 249

  Fly   361 LDATFAQCGADIAEGSLEHVGVPAVIEQECHLEALKYQLHTSYMSKVNIHELYQCDVMKYVNEF- 424
            ||........|:|:|.....||||:||.:.|:..::..:......::.:.|.:|.||.|.|.:|
  Rat   250 LDRALWHLSCDVADGKYREKGVPALIENDHHMNCIRKIIWEDIFPRIQLWEFFQVDVQKAVEQFR 314

  Fly   425 --MSQVR---TREPPKNVANECRFQEIQLIQDPQYRRLASTINFELALEIFNAF-HGDCFDEESR 483
              :||..   |:..||        :.:::||||::|||...::..:||..|... :|....||
  Rat   315 RLLSQENRRVTKSEPK--------EHLKIIQDPEFRRLGCAVDMNIALATFIPHDNGPAAIEE-- 369

  Fly   484 FRKCAETLRRHLDALNDRVRCEVQGYINYAIDNVLAGVRYERVQGDGPRVKEISEKHSVFMVYFT 548
               |....|:.|:.||.........:...|::.:|..|.|||:.|.||::..::.|:.:...|||
  Rat   370 ---CCNWFRKRLEELNSEKHHLTSCHQEQAVNCLLGNVFYERLAGHGPKLGPVTRKYPLVTRYFT 431

  Fly   549 HTGTQGKSLTEIEADMY--TKAGEFFMAHNGWVMGYSDPLRDFAEEQPGRANVYLKRELISWGDS 611
            .. .:..:|:..|:.::  .||. |.||||||||| .||||:|||  || :||||:||||.||||
  Rat   432 FP-FEEMALSAEESLLHRPDKAC-FLMAHNGWVMG-DDPLRNFAE--PG-SNVYLRRELICWGDS 490

  Fly   612 VKLRFGRRPEDSPYLWQHMTEYVQTTARIFDGVRLDNCHSTPLHVAEYLLDAARKINPELYVVAE 676
            ||||:|.:|||.||||.||.:|.:.||..|.|||||||||||||||||:||||||:.|.||||||
  Rat   491 VKLRYGNKPEDCPYLWAHMKKYTEITATHFQGVRLDNCHSTPLHVAEYMLDAARKLQPNLYVVAE 555

  Fly   677 LFTNSDYTDNVFVNRLGITSLIREALSAWDSHEQGRLVYRYGGVPVGGFQANSSRHEATSVAHAL 741
            |||.|:..||:||.||||:||||||:||::|||:|||||||||.|||.|.....|....::||||
  Rat   556 LFTGSEDLDNIFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPLMPAIAHAL 620

  Fly   742 FLDLTHDNPSPVEKRSVYDLLPSAALVSMACCATGSNRGYDELVPHHIHVVDEERTYQEWGKG-- 804
            |:|:||||..|:..||.||.|||..:|||||||:||.|||||||||.|.||.|||.|.:|..|
  Rat   621 FMDITHDNECPIVHRSAYDALPSTTVVSMACCASGSTRGYDELVPHQISVVAEERFYTKWNPGAS 685

  Fly   805 ------VDSKSGIMGAKRALNLLHGQLAEEGFSQVYVDQMDPNVVAVTRHSPITHQSVILVAHTA 863
                  |...|||:.|:.|:|.||.:|..:||.||||||:|.::||||||||..||||:.|:.||
  Rat   686 PSDTGDVSIHSGIIAARCAINRLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQSVVAVSRTA 750

  Fly   864 FGYPSPNAGPTGIRPLRFEGVLDEIILEASLTMQSDKPFDRPAPFKKDPNVINGFTQFQLNLQEH 928
            |..|..:.....:..:...|.::|::|||....::.|      |::||.|.|||.....:.|:|.
  Rat   751 FRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTK------PYRKDENSINGMPNMTVELRER 809

  Fly   929 IPLAKSTVF-QTQAYSDGNN---TELNFANLRPGTVVAIRVSMHPGPR----------TSFDKLQ 979
            |.|.:|.:. |....:.|.|   .|:.|.||.||:|:..|||:.|..:          |.|....
  Rat   810 IQLHESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNHLTQFSSHF 874

  Fly   980 KISAALRIGSGEEYSQL--QAIVSKLDLVALSGALFSCDDEERDLGKGGTAYDIPNFGKIVYCGL 1042
            | |.:|.:.:.:...::  .:|.|||.|..|:..|:.|:.||::  .||..|||||:..:.|.||
  Rat   875 K-SGSLAVDNSDPILKIPFASIASKLTLAELNQVLYRCESEEQE--DGGGCYDIPNWSSLKYAGL 936

  Fly  1043 QGFISLLTEISPKNDLGHPLCNNLRDGNWMMDYISDRLTSYE-DLKPLSAWFKATFEPLKNIPRY 1106
            ||.:|:|.||.||||||||.|.|||.|:||:||:|.||.|.. .:..:..|.:|.|..||.||||
  Rat   937 QGLMSVLAEIRPKNDLGHPFCENLRSGDWMIDYVSGRLISRSGSIAEVGKWLQAMFFYLKQIPRY 1001

  Fly  1107 LIPCYFDAIVSGVYNVLINQVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSANLPGFSPAL--- 1168
            |||||||||:.|.|..|::...:.|..|::||.:|.:.|:|.::|...|.|...||..||:|
  Rat  1002 LIPCYFDAILIGAYTTLLDVAWKQMSSFVQNGSTFVKHLSLGSVQMCGVGKCPCLPLLSPSLLDV 1066

  Fly  1169 -----SPPKPPKQ-CVTLSAGLPHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFIIIGFGQTL 1227
                 ...|..:| |.:|:|||||||:|..|||||||||||||.:.:||||.|||.||:.|..||
  Rat  1067 PCRLNEITKEKEQCCASLAAGLPHFSSGLFRCWGRDTFIALRGMLLVTGRYLEARNIILAFACTL 1131

  Fly  1228 RHGLIPNLLDSGSKPRFNCRDAIWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDADAHAPGAF 1292
            |||||||||..|:..|:|||||:|||:.||:.|.:..|.|.:|||..|||::|.||:.....|..
  Rat  1132 RHGLIPNLLGEGTYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTL 1196

  Fly  1293 DQLLFDVMQEALQVHFQGLQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNNFNCGTWMD 1357
            ||.||:|:|||:|.|.||:|:||||||.:||.:|.|:|||..:|:..|||||:|||.||||||||
  Rat  1197 DQPLFEVIQEAMQRHMQGIQFRERNAGPQIDRNMKDEGFNITVGVDEETGFVYGGNRFNCGTWMD 1261

  Fly  1358 KMGSSQKAGNKGRPSTPRDGSAVELVGLQYAVLRFMQSLAEKEVIPYTGVERKGPSGEVTKWSYK 1422
            |||.|.:|.|:|.|:|||||||||:|||..:.:|::..|::|.:.||..| |....|:|...||.
  Rat  1262 KMGESDRARNRGIPATPRDGSAVEIVGLCKSAVRWLLELSKKNIFPYHEV-RVRRHGKVVAVSYD 1325

  Fly  1423 EWADRIKNNFDKYFFVSESET------CSVANKKLIYKDSYGATQSWTDYQLRCNFPITLTVAPD 1481
            ||..:|:|:|:|.|.|||..:      .::.:|:.||||||||:..|.|||||.||.|.:.|||:
  Rat  1326 EWNRKIQNSFEKLFHVSEDPSDPNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPNFTIAMVVAPE 1390

  Fly  1482 LCNPQNAWRALERAKKYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQGPEWVWPI 1546
            |...:.||:|||.|:..|||||||||:||:|..|...|||:.|:.:..:|.|.||||||||:|||
  Rat  1391 LFTAEKAWKALEIAEGKLLGPLGMKTLDPDDMVYCGVYDNALDNDNYNLARGFNYHQGPEWLWPI 1455

  Fly  1547 GFYLRARLIFAKKCGHLDETIAET----WAILRAHLRELQTSHWRGLPELTNDNGSYCGDSCRTQ 1607
            |::|||:|.|:|..|  .||.|:|    ..:|..|...|:.|.|:|||||||:||.||..||.||
  Rat  1456 GYFLRAKLYFSKMMG--PETAAKTVFLVKNVLSRHYVHLERSPWKGLPELTNENGQYCPFSCETQ 1518

  Fly  1608 AWSVAAILEVLYDL 1621
            |||:||:||.||||
  Rat  1519 AWSMAAVLETLYDL 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	731/1562 (47%)
		hGDE_N	121..224	CDD:291371	29/102 (28%)
		AmyAc_Glg_debranch_2	212..704	CDD:200466	228/501 (46%)
		hGDE_central	810..1080	CDD:291374	115/285 (40%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	32/74 (43%)
		GDE_C	1147..1616	CDD:283786	259/487 (53%)
Agl	NP_001102034.1	glyc_debranch	22..1532	CDD:273673	731/1562 (47%)
		hGDE_N	31..116	CDD:291371	29/102 (28%)
		AmyAc_Glg_debranch_2	105..583	CDD:200466	229/505 (45%)
		hGDE_central	697..974	CDD:291374	115/285 (40%)
		GDE_C	1073..1527	CDD:283786	250/456 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340562
Domainoid	1	1.000	513	1.000	Domainoid score	I306
eggNOG	1	0.900	-	-		E1_COG3408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H536
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I125
OMA	1	1.010	-	-		QHG54289
OrthoDB	1	1.010	-	-		D31743at33208
OrthoFinder	1	1.000	-	-		FOG0006187
OrthoInspector	1	1.000	-	-		oto98206
orthoMCL	1	0.900	-	-		OOG6_103063
Panther	1	1.100	-	-	LDO	PTHR10569
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3932
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770