DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9485 and AGL

DIOPT Version :9

Sequence 1:	NP_726062.2	Gene:	CG9485 / 37435	FlyBaseID:	FBgn0034618	Length:	1629	Species:	Drosophila melanogaster
Sequence 2:	NP_000019.2	Gene:	AGL / 178	HGNCID:	321	Length:	1532	Species:	Homo sapiens

Alignment Length:	1582	Identity:	738/1582 - (46%)
Similarity:	999/1582 - (63%)	Gaps:	101/1582 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 MGKETESHSIPISEGQDAEHILYRLKRGSKLSVHPDASLLGRKIVLYTNYPAEGQKFVRTEYRVL 155
            ||...:...:.::|.:..|..|:||::|.:|......:|.|:.:.:|||||..|:.|.|.::|.|
Human     1 MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAVTVYTNYPFPGETFNREKFRSL 65

  Fly   156 GWQLSNGKQITSVMHPEAHVVDTDIRSQVELNMSGTYHFYFRYLERPDTGCSGADGALYVQVEPT 220
            .|:           :|.....|:|...::.|..||::.:||  |:..:....|     |:.|:|.
Human    66 DWE-----------NPTEREDDSDKYCKLNLQQSGSFQYYF--LQGNEKSGGG-----YIVVDPI 112

  Fly   221 LHVGPPGAQKTIPLDSVRCQTVLAKLLGPLDTWEPKLRVAKEAGYNVIHFTPIQELGGSRSCYSL 285
            |.||  .....:|||.|..||.|||.|||.|.||.:||||||:|||:|||||:|.||.|||||||
Human   113 LRVG--ADNHVLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSL 175

  Fly   286 RDQLKVNSHFA-PQKGGKISFEDVEKVIKKCRQEWGVASICDIVLNHTANESDWLLQHPDATYSC 349
            .:||::|..|: |.:  |.::.||.::::|.::||.|..|.|:|.||||..|.|:.:||:..|:.
Human   176 ANQLELNPDFSRPNR--KYTWNDVGQLVEKLKKEWNVICITDVVYNHTAANSKWIQEHPECAYNL 238

  Fly   350 ATCPYLRPAFLLDATFAQCGADIAEGSLEHVGVPAVIEQECHLEALKYQLHTSYMSKVNIHELYQ 414
            ...|:|:||::||....:...|:|||..:..|:||:||.:.|:.:::..:......|:.:.|.:|
Human   239 VNSPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIENDHHMNSIRKIIWEDIFPKLKLWEFFQ 303

  Fly   415 CDVMKYVNEFMSQVRTREPPKNVANECRFQEIQLIQDPQYRRLASTINFELALEIFNAF-HGDCF 478
            .||.|.|.:| .::.|:| .:.|......|.:.:||||:|||...|::..:||..|... .|...
Human   304 VDVNKAVEQF-RRLLTQE-NRRVTKSDPNQHLTIIQDPEYRRFGCTVDMNIALTTFIPHDKGPAA 366

  Fly   479 DEESRFRKCAETLRRHLDALNDRVRCEVQGYINY----AIDNVLAGVRYERVQGDGPRVKEISEK 539
            .||     |.....:.::.||.    |....|||    |::.:|..|.|||:.|.||::..::.|
Human   367 IEE-----CCNWFHKRMEELNS----EKHRLINYHQEQAVNCLLGNVFYERLAGHGPKLGPVTRK 422

  Fly   540 HSVFMVYFTHTGTQ-GKSLTEIEADMYTKAGEFFMAHNGWVMGYSDPLRDFAEEQPGRANVYLKR 603
            |.:...|||....: ..|:.|....:..||. |.||||||||| .||||:|||  || :.|||:|
Human   423 HPLVTRYFTFPFEEIDFSMEESMIHLPNKAC-FLMAHNGWVMG-DDPLRNFAE--PG-SEVYLRR 482

  Fly   604 ELISWGDSVKLRFGRRPEDSPYLWQHMTEYVQTTARIFDGVRLDNCHSTPLHVAEYLLDAARKIN 668
            |||.||||||||:|.:|||.||||.||.:|.:.||..|.|||||||||||||||||:|||||.:.
Human   483 ELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHSTPLHVAEYMLDAARNLQ 547

  Fly   669 PELYVVAELFTNSDYTDNVFVNRLGITSLIREALSAWDSHEQGRLVYRYGGVPVGGFQANSSRHE 733
            |.|||||||||.|:..|||||.||||:||||||:||::|||:|||||||||.|||.|.....|..
Human   548 PNLYVVAELFTGSEDLDNVFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEPVGSFVQPCLRPL 612

  Fly   734 ATSVAHALFLDLTHDNPSPVEKRSVYDLLPSAALVSMACCATGSNRGYDELVPHHIHVVDEERTY 798
            ..::|||||:|:||||..|:..||.||.|||..:|||||||:||.|||||||||.|.||.|||.|
Human   613 MPAIAHALFMDITHDNECPIVHRSAYDALPSTTIVSMACCASGSTRGYDELVPHQISVVSEERFY 677

  Fly   799 QEWGK--------GVDSKSGIMGAKRALNLLHGQLAEEGFSQVYVDQMDPNVVAVTRHSPITHQS 855
            .:|..        .|:.:|||:.|:.|::.||.:|..:||.||||||:|.::||||||||..|||
Human   678 TKWNPEALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQVYVDQVDEDIVAVTRHSPSIHQS 742

  Fly   856 VILVAHTAFGYPSPNAGPTGIRPLRFEGVLDEIILEASLTMQSDKPFDRPAPFKKDPNVINGFTQ 920
            |:.|:.|||..|..:.....:..:...|.::|::|||....::.|      |::||.|.|||...
Human   743 VVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEARTIERNTK------PYRKDENSINGTPD 801

  Fly   921 FQLNLQEHIPLAKSTVF-QTQAYSDGNN---TELNFANLRPGTVVAIRVSMHPGPR--------- 972
            ..:.::|||.|.:|.:. |....:.|.|   .|:.|.||.||:|:..|||:.|..:
Human   802 ITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENLSPGSVIIFRVSLDPHAQVAVGILRNH 866

  Fly   973 -TSFDKLQKISAALRIGSGEEYSQL--QAIVSKLDLVALSGALFSCDDEERDLGKGGTAYDIPNF 1034
             |.|....| |.:|.:.:.:...::  .::.|:|.|..|:..|:.|:.||::  .||..|||||:
Human   867 LTQFSPHFK-SGSLAVDNADPILKIPFASLASRLTLAELNQILYRCESEEKE--DGGGCYDIPNW 928

  Fly  1035 GKIVYCGLQGFISLLTEISPKNDLGHPLCNNLRDGNWMMDYISDRLTSYE-DLKPLSAWFKATFE 1098
            ..:.|.||||.:|:|.||.||||||||.|||||.|:||:||:|:||.|.. .:..:..|.:|.|.
Human   929 SALKYAGLQGLMSVLAEIRPKNDLGHPFCNNLRSGDWMIDYVSNRLISRSGTIAEVGKWLQAMFF 993

  Fly  1099 PLKNIPRYLIPCYFDAIVSGVYNVLINQVNELMPDFIKNGHSFPQSLALSTLQFLSVCKSANLPG 1163
            .||.|||||||||||||:.|.|..|::...:.|..|::||.:|.:.|:|.::|...|.|..:||.
Human   994 YLKQIPRYLIPCYFDAILIGAYTTLLDTAWKQMSSFVQNGSTFVKHLSLGSVQLCGVGKFPSLPI 1058

  Fly  1164 FSPALSP--------PKPPKQ-CVTLSAGLPHFSTGYMRCWGRDTFIALRGSMFLTGRYNEARFI 1219
            .||||..        .|..:| ||:|:|||||||:|..|||||||||||||.:.:||||.|||.|
Human  1059 LSPALMDVPYRLNEITKEKEQCCVSLAAGLPHFSSGIFRCWGRDTFIALRGILLITGRYVEARNI 1123

  Fly  1220 IIGFGQTLRHGLIPNLLDSGSKPRFNCRDAIWWWMYCIKQYVEDAPKGAEILKDKVSRIFPYDDA 1284
            |:.|..|||||||||||..|...|:|||||:|||:.||:.|.:..|.|.:|||..|||::|.||:
Human  1124 ILAFAGTLRHGLIPNLLGEGIYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDS 1188

  Fly  1285 DAHAPGAFDQLLFDVMQEALQVHFQGLQYRERNAGYEIDAHMVDQGFNNQIGIHPETGFVFGGNN 1349
            .....|..||.||:|:|||:|.|.||:|:||||||.:||.:|.|:|||...|:..|||||:|||.
Human  1189 APLPAGTLDQPLFEVIQEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNR 1253

  Fly  1350 FNCGTWMDKMGSSQKAGNKGRPSTPRDGSAVELVGLQYAVLRFMQSLAEKEVIPYTGVERKGPSG 1414
            |||||||||||.|.:|.|:|.|:|||||||||:|||..:.:|::..|::|.:.||..|..| ..|
Human  1254 FNCGTWMDKMGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVK-RHG 1317

  Fly  1415 EVTKWSYKEWADRIKNNFDKYFFVSESET------CSVANKKLIYKDSYGATQSWTDYQLRCNFP 1473
            :..|.||.||..:|::||:|.|.|||..:      .::.:|:.||||||||:..|.|||||.||.
Human  1318 KAIKVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPNFT 1382

  Fly  1474 ITLTVAPDLCNPQNAWRALERAKKYLLGPLGMKTMDPEDWNYRANYDNSNDSTDCTVAHGANYHQ 1538
            |.:.|||:|...:.||:|||.|:|.|||||||||:||:|..|...|||:.|:.:..:|.|.||||
Human  1383 IAMVVAPELFTTEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLAKGFNYHQ 1447

  Fly  1539 GPEWVWPIGFYLRARLIFAKKCGHLDETIAETWA----ILRAHLRELQTSHWRGLPELTNDNGSY 1599
            ||||:||||::|||:|.|::..|  .||.|:|..    :|..|...|:.|.|:|||||||:|..|
Human  1448 GPEWLWPIGYFLRAKLYFSRLMG--PETTAKTIVLVKNVLSRHYVHLERSPWKGLPELTNENAQY 1510

  Fly  1600 CGDSCRTQAWSVAAILEVLYDL 1621
            |..||.|||||:|.|||.||||
Human  1511 CPFSCETQAWSIATILETLYDL 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9485	NP_726062.2	RNA_pol_I_A49	<30..>76	CDD:284324
		glyc_debranch	112..1621	CDD:273673	732/1559 (47%)
		hGDE_N	121..224	CDD:291371	28/102 (27%)
		AmyAc_Glg_debranch_2	212..704	CDD:200466	232/498 (47%)
		hGDE_central	810..1080	CDD:291374	113/285 (40%)
		Glycosyltransferase_GTB_type	<1076..>1150	CDD:299143	32/74 (43%)
		GDE_C	1147..1616	CDD:283786	260/487 (53%)
AGL	NP_000019.2	glyc_debranch	22..1532	CDD:273673	732/1559 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146908
Domainoid	1	1.000	512	1.000	Domainoid score	I315
eggNOG	1	0.900	-	-		E1_COG3408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H536
Inparanoid	1	1.050	1359	1.000	Inparanoid score	I134
Isobase	1	0.950	-	0	Normalized mean entropy	S2301
OMA	1	1.010	-	-		QHG54289
OrthoDB	1	1.010	-	-		D31743at33208
OrthoFinder	1	1.000	-	-		FOG0006187
OrthoInspector	1	1.000	-	-		oto91112
orthoMCL	1	0.900	-	-		OOG6_103063
Panther	1	1.100	-	-	LDO	PTHR10569
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2125
SonicParanoid	1	1.000	-	-		X3932
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750