DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and Ankrd50

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_001360823.1	Gene:	Ankrd50 / 99696	MGIID:	2139777	Length:	1427	Species:	Mus musculus

Alignment Length:	511	Identity:	159/511 - (31%)
Similarity:	242/511 - (47%)	Gaps:	64/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 IDDRDENATTVLMVVAGRGLTAFVREFLARGADVQAEDLDNWTAL----LCA-SRNGHLDVVQLL 255
            ::..|....|.|:..|..|....|...|..||:|..||:|..|||    ||. :..||..||.||
Mouse   670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734

  Fly   256 LDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGADGNAHGNYHLGALLWAAGRGYKDIVEL 320
            :|.||||:|.|..|.|.|:.|||.||.::|.|||:.|||.:...|.....||.||..|:..:|..
Mouse   735 IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799

  Fly   321 LVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAG---ANVDTAGMYSWTPL---------- 372
            |:..||.|:..|..|.|.|..|..:||||:|.|||..|   ::.|.||   ||||
Mouse   800 LLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDESHRDDAG---WTPLHMAAFEGHRL 861

  Fly   373 -----------------------LVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQ 414
                                   ::|:..||.|||..:||.|.|::....||..||.:|:.||.:
Mouse   862 ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926

  Fly   415 DIAASLIAAGAYINIQDR-GADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKG 478
            ||...|.:.||.:|.:|. |..|..|.|:: ...|:.|..|:..|:|:....:.:||::.:..:|
Mouse   927 DIVELLFSHGADVNYKDADGRPTLYILALE-NQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990

  Fly   479 HTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRA 543
            |..:|::|:|.:.|:.:|..:..:.|..|....::::|.||::..|.|..:..:|.|.|.||.:.
Mouse   991 HVEMVRVLIACHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055

  Fly   544 RSKTIVEALLR---NPKHSQLLYRANKAGETPYNIDSL--HQKTI-LGQVFGARRLNTNEDSEGM 602
            ....:|:.||.   :|.|      |::.|.|...:.:.  |.:.| |.:.:||..||      |.
Mouse  1056 GHVDVVQVLLEHGADPNH------ADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLN------GC 1108

  Fly   603 LGYELYSSALADVLSEPTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEP 658
            ....:::.......|.|:....:|:...:..|:|...|...||...|..|..::.|
Mouse  1109 SPSPVHTMEQKPPQSAPSKMQSLTIRSNSSGGTGGGDLQPSLRGLPNGPAHAFSSP 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	41/97 (42%)
		Ank_2	173..266	CDD:289560	30/74 (41%)
		ANK repeat	205..233	CDD:293786	9/27 (33%)
		ANK	231..355	CDD:238125	58/128 (45%)
		ANK repeat	235..266	CDD:293786	18/35 (51%)
		Ank_2	240..332	CDD:289560	42/96 (44%)
		ANK repeat	268..299	CDD:293786	15/30 (50%)
		ANK repeat	301..332	CDD:293786	10/30 (33%)
		Ank_2	306..398	CDD:289560	41/127 (32%)
		ANK	329..454	CDD:238125	51/161 (32%)
		ANK repeat	334..362	CDD:293786	13/30 (43%)
		ANK repeat	367..398	CDD:293786	14/63 (22%)
		ANK repeat	400..431	CDD:293786	13/30 (43%)
		Ank_4	401..454	CDD:290365	19/53 (36%)
		ANK	428..553	CDD:238125	33/125 (26%)
		ANK repeat	435..464	CDD:293786	8/28 (29%)
		Ank_2	438..530	CDD:289560	23/91 (25%)
		ANK repeat	466..497	CDD:293786	8/30 (27%)
		ANK repeat	499..530	CDD:293786	7/30 (23%)
		Ank_5	518..575	CDD:290568	17/59 (29%)
		KAP_NTPase	605..1136	CDD:284995	11/54 (20%)
		SAM_superfamily	1357..1392	CDD:188886
Ankrd50	NP_001360823.1	AAA_16	23..195	CDD:379062
		Cas9_REC	<251..>352	CDD:391787
		PHA03095	480..>717	CDD:222980	16/46 (35%)
		ANK repeat	544..575	CDD:293786
		ANK repeat	577..608	CDD:293786
		ANK repeat	610..641	CDD:293786
		PHA03095	625..>907	CDD:222980	88/239 (37%)
		ANK repeat	643..674	CDD:293786	0/3 (0%)
		ANK repeat	676..707	CDD:293786	9/30 (30%)
		ANK repeat	709..745	CDD:293786	18/35 (51%)
		ANK repeat	747..778	CDD:293786	15/30 (50%)
		PHA02876	<763..>1102	CDD:165207	104/348 (30%)
		ANK repeat	780..811	CDD:293786	10/30 (33%)
		ANK repeat	813..844	CDD:293786	13/30 (43%)
		ANK repeat	847..877	CDD:293786	5/32 (16%)
		ANK repeat	879..910	CDD:293786	10/30 (33%)
		ANK repeat	912..943	CDD:293786	13/30 (43%)
		ANK repeat	945..976	CDD:293786	9/31 (29%)
		ANK repeat	978..1009	CDD:293786	8/30 (27%)
		ANK repeat	1011..1042	CDD:293786	7/30 (23%)
		ANK repeat	1044..1075	CDD:293786	10/36 (28%)
		ANK repeat	1077..1102	CDD:293786	5/24 (21%)
		THRAP3_BCLAF1	1225..>1339	CDD:373846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910