DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and Kidins220

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_006515313.1	Gene:	Kidins220 / 77480	MGIID:	1924730	Length:	1794	Species:	Mus musculus

Alignment Length:	1625	Identity:	570/1625 - (35%)
Similarity:	865/1625 - (53%)	Gaps:	212/1625 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 MGSLGHRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADV 229
            |..|..::::.|::..:|..|:|:|: :...:|:|:|...|.||:.|.:|....|:|.:..||:.
Mouse     1 MSVLISQSVINYVEEENIPALKALLE-KCKDVDERNECGQTPLMIAAEQGNVEIVKELIKNGANC 64

  Fly   230 QAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGAD 294
            ..|||||||||:.||:.||:.:|:.||..||.:|||||||||:||||.|:|.|::|.|||..||:
Mouse    65 NLEDLDNWTALISASKEGHIHIVEELLKCGANLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 129

  Fly   295 GNAHG-NYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAG 358
            .:..| .|.:..::||||||:.|||.||:|.|||||..||||||.||||.|:|::|.|..||..|
Mouse   130 PSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 194

  Fly   359 ANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAA 423
            |:||..|..|.|.|:||..||:|..|..||::.||||..||||.|||.|||:||..:|...|:.|
Mouse   195 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHIEIVQDLLDA 259

  Fly   424 GAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLA 488
            |.|:||.||..||.||.||:.||..:|.|||:|:||:||:|:|.|||:|.|||||:..:|:.:|.
Mouse   260 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 324

  Fly   489 TNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALL 553
            .|||.|..||||:|||::|.:.||:|:|.||||:.|:|:|.||:|||.||:|:|.||:.:.|.||
Mouse   325 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGARVSAVDKKGDTPLHVAIRGRSRRLAELLL 389

  Fly   554 RNPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSE 618
            ||||..:||||.|||||||||||..|||:||.|:||||.|:..|....||||:||||||||:|||
Mouse   390 RNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSE 454

  Fly   619 PTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEPPIRTSGLLFIVCLHVALLIG--TIV 681
            ||:..||.|||||:|||||||||.||.|||..||.|..||..:.|.|:..:.|   ||.|  .:|
Mouse   455 PTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLIL---LLCGGLGLV 516

  Fly   682 GLSTWSAVVGVSAAVGFLLLAYLLLAAVRYCNYQ--MDMQWAYSVQHGLEKRMTRLRLILQVAFC 744
            ...|....:.::.::.||.|.|:....:.:...|  ....||:::...|.:.:..|.|:.::.|.
Mouse   517 FAFTVDTNLAIAVSLSFLALLYIFFIVIYFGGRQEGESWNWAWALSTRLARHIGYLELLFKLMFV 581

  Fly   745 HPPG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKCL 807
            :||. |:..::|.||||.|.:.|..|.. |:.::|.|:|.|.||.|..:|:|||||:|.|:.:..
Mouse   582 NPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDS 646

  Fly   808 KVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILV--ALYVIAAVMGTL 870
            :...  :|::.||:|..:||...:..::.||:|...:     ..:.:|:.|  .|..||:::|..
Mouse   647 QGKK--KWKKTCCLPSFIIFLFIVGCIIAGITLLAIF-----RVDPKHLTVNAILISIASIVGLA 704

  Fly   871 ICTHLHVLAKVFVSLFTSHIRVLKRAV----RSSESAPLTMLGAEVAVMTDMVKCLDAFTNQQSR 931
            ...:.....:|..||..|..:.|..|.    :......:.:|..||.:|..|.|.:|:||..|:|
Mouse   705 FVLNCRTWWQVLDSLLNSQRKRLHSAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTR 769

  Fly   932 LVGVIDALDSCDTERILTLLNAVQTLLSSPNRPFVLLISVDPHVIAKAAEANSRRLFTEGGIGGH 996
            ||.:||.||:|:.:::|.:|:.|:.|.|  ..||:.:.:.|||:|.||...|...:..:..|.||
Mouse   770 LVVIIDGLDACEQDKVLQMLDTVRVLFS--KGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGH 832

  Fly   997 DFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSARRLSNASEIISS 1061
            |::||:|||||:|.:.||...::..:|:     :..||....:...:..... ||:|..|  :..
Mouse   833 DYMRNIVHLPVFLNSRGLSNARKFLVTS-----ATNGDISCSEATGVQEDAD-RRVSQNS--LGE 889

  Fly  1062 QEKLRGPARGGGGKKLRLSESVASSTGSNLHRLGQNPQTV-----LDLSRIVLTDDYFSDVNPRS 1121
            ..||        |.|..|:.       .:.:|..|..:|:     .||:::::|:|:|||::|::
Mouse   890 MTKL--------GSKTALNR-------RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQT 939

  Fly  1122 MRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIVLHHDQFMDSNADESVSLQSV 1186
            ||||:|::.:|.|||:|.||.|:|.||:||||||||||.|.|.::|:..:  .....:.::|:::
Mouse   940 MRRLLNIVSVTGRLLRANQITFNWDRLASWINLTEQWPYRTSWLILYLGE--TEGIPDQMTLKTI 1002

  Fly  1187 YEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHKSDLLVADLRIFLPFTINLDPYLRKVLKEDQ 1251
            ||::...:...::..||||:|.|.|..:.||......|:..|::.|||.|:||||.||:::.:.:
Mouse  1003 YERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKTFLPCTVNLDPKLREIIADVR 1067

  Fly  1252 QTIE--DEGSLVIQARP----------------SVSNTMRQF--PAPTTYV-PSPQA-------- 1287
            ...|  :.|.|.....|                ||.::...|  |.|...| |.|.:
Mouse  1068 AAREQINIGGLAYPPLPLHEAPPRPPSGYSQPASVCSSSASFNGPFPGGVVSPQPHSSYYSGLSG 1132

  Fly  1288 ----------YPPYQMFQNEYP--ANELRSRN-------------LSTSTEPVTPLINSPSDS-- 1325
                      :.||......||  :..|.||:             |....|.....:.||:.|
Mouse  1133 PQHPFYNRPFFAPYLYTPRYYPGGSQHLISRSSVKTSLPRDQNNGLEVIKEDAAEGLPSPTASSR 1197

  Fly  1326 ---------------------------FGDDILQTKLTDLTVEGVISLLDRIEDM-KPALPKLAP 1362
                                       .|..:|   |:.:||:.|...|.:||.: :..||:...
Mouse  1198 EKSWTRKQLMELCDSGFNKQRQASVPATGTSLL---LSSMTVDIVCEKLRQIEGLDQGMLPQYCT 1259

  Fly  1363 VLRENAINGRVLKHCDMPDLKSVLGLSFGHWELFRLLITTLRECERL-----PRKQQRQQQQPGA 1422
            .:::..||||||..|::.:||..:.::||.|.|||.::..:|..|..     ||........|.|
Mouse  1260 TIKKANINGRVLAQCNIDELKKEMAMNFGDWHLFRSMVLEMRSVENQVVPEDPRFLNENSSAPVA 1324

  Fly  1423 ---------------LEAPSNVPMIKDVTDALMQ--------PPRESLS------RKNSVSHMEK 1458
                           .|..|..|...:.:...:.        |...:||      |..|:|.:..
Mouse  1325 HGESARRTSHSELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNS 1389

  Fly  1459 Q-VTLEEQMICGTLQTLNEEAYEDVAS--SERPSPTELDTPSA-GAAMTTPLLGASGS------- 1512
            | .::|...:...:|....:||.:..:  |:....|...|.|. .:..:|..:|.|.|
Mouse  1390 QDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGTGSSTISGRSSPHSTYYIGQSSSGGSIHSN 1454

  Fly  1513 VPAPSGRESILKQQGSVKA--DKRVSIQQMATSNNNNNNSTKLTPNVEYVSERQPEVQGAGKRLT 1575
            :....|:|:.|||:...|:  .||..:...::|..:.|.::.|.|    ::|...:...:|.:|.
Mouse  1455 LEQERGKENELKQEEGRKSFLMKRGDVLDYSSSGVSTNEASPLDP----ITEEDEKSDQSGSKLL 1515

  Fly  1576 TKPPPGPRPASLIITRNDSNSQFQL---LRSSSVDYDDVEAQEHRT----TIRTTLLEQQEEEES 1633
            .......||           |.||.   |:.|.:.|..:.:.|..:    :..|.||:..:::::
Mouse  1516 PGKKSSERP-----------SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDKKA 1569

Fly 1634 1633
Mouse 1570 1569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	53/119 (45%)
		Ank_2	173..266	CDD:289560	37/92 (40%)
		ANK repeat	205..233	CDD:293786	9/27 (33%)
		ANK	231..355	CDD:238125	73/124 (59%)
		ANK repeat	235..266	CDD:293786	17/30 (57%)
		Ank_2	240..332	CDD:289560	51/92 (55%)
		ANK repeat	268..299	CDD:293786	17/30 (57%)
		ANK repeat	301..332	CDD:293786	18/30 (60%)
		Ank_2	306..398	CDD:289560	53/91 (58%)
		ANK	329..454	CDD:238125	68/124 (55%)
		ANK repeat	334..362	CDD:293786	16/27 (59%)
		ANK repeat	367..398	CDD:293786	15/30 (50%)
		ANK repeat	400..431	CDD:293786	17/30 (57%)
		Ank_4	401..454	CDD:290365	28/52 (54%)
		ANK	428..553	CDD:238125	69/124 (56%)
		ANK repeat	435..464	CDD:293786	17/28 (61%)
		Ank_2	438..530	CDD:289560	51/91 (56%)
		ANK repeat	466..497	CDD:293786	16/30 (53%)
		ANK repeat	499..530	CDD:293786	17/30 (57%)
		Ank_5	518..575	CDD:290568	37/56 (66%)
		KAP_NTPase	605..1136	CDD:284995	183/547 (33%)
		SAM_superfamily	1357..1392	CDD:188886	12/34 (35%)
Kidins220	XP_006515313.1	Ank_4	13..58	CDD:372654	14/45 (31%)
		ANK repeat	38..68	CDD:293786	9/29 (31%)
		PHA02874	49..>378	CDD:165205	182/328 (55%)
		ANK repeat	70..101	CDD:293786	17/30 (57%)
		ANK repeat	103..132	CDD:293786	17/28 (61%)
		ANK repeat	170..198	CDD:293786	16/27 (59%)
		ANK repeat	236..267	CDD:293786	17/30 (57%)
		ANK repeat	269..299	CDD:293786	16/29 (55%)
		ANK repeat	302..332	CDD:293786	16/29 (55%)
		ANK repeat	335..366	CDD:293786	17/30 (57%)
		PHA02736	<349..413	CDD:165103	41/63 (65%)
		KAP_NTPase	441..954	CDD:284995	183/547 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1564
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14254
Inparanoid	1	1.050	901	1.000	Inparanoid score	I379
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46561
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		oto92725
orthoMCL	1	0.900	-	-		OOG6_106563
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3637
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900