DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42672 and KIDINS220

DIOPT Version :9

Sequence 1:NP_726059.5 Gene:CG42672 / 37433 FlyBaseID:FBgn0261554 Length:1642 Species:Drosophila melanogaster
Sequence 2:NP_001335658.1 Gene:KIDINS220 / 57498 HGNCID:29508 Length:1772 Species:Homo sapiens


Alignment Length:1635 Identity:581/1635 - (35%)
Similarity:872/1635 - (53%) Gaps:237/1635 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 MGSLGHRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADV 229
            |..|..::::.|::..:|..|:|:|: :...:|:|:|...|.||:.|.:|....|:|.:..||:.
Human     1 MSVLISQSVINYVEEENIPALKALLE-KCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64

  Fly   230 QAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGAD 294
            ..|||||||||:.||:.||:.:|:.||..|..:|||||||||:||||.|:|.|::|.|||..||:
Human    65 NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 129

  Fly   295 GNAHG-NYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAG 358
            .:..| .|.:..::||||||:.|||.||:|.|||||..||||||.||||.|:|::|.|..||..|
Human   130 PSVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 194

  Fly   359 ANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAA 423
            |:||..|..|.|.|:||..||:|..|..||::.||||..||||.|||.|||:||..:|...|:.|
Human   195 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 259

  Fly   424 GAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLA 488
            |.|:||.||..||.||.||:.||..:|.|||:|:||:||:|:|.|||:|.|||||:..:|:.:|.
Human   260 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 324

  Fly   489 TNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALL 553
            .|||.|..||||:|||::|.:.||:|:|.||||:.|||:|.||:|||.||||:|.||:.:.|.||
Human   325 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 389

  Fly   554 RNPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSE 618
            ||||..:||||.|||||||||||..|||:||.|:||||.|:..|....||||:||||||||:|||
Human   390 RNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSE 454

  Fly   619 PTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEPPIRTSGLLFIVCLHVALLIGTIVGL 683
            ||:..||.|||||:|||||||||.||.|||..||.|..||..:.|.|:..:.|   ||.|   ||
Human   455 PTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTL---LLCG---GL 513

  Fly   684 STWSAV-----VGVSAAVGFLLLAYLLLAAVRYCNYQ--MDMQWAYSVQHGLEKRMTRLRLILQV 741
            ....|.     :|::.::.||.|.|:....:.:...:  ....||:.:...|.:.:..|.|:|::
Human   514 GLLFAFTVHPNLGIAVSLSFLALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKL 578

  Fly   742 AFCHPPG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRP 804
            .|.:||. |:..::|.||||.|.:.|..|.. |:.::|.|:|.|.||.|..:|:|||||:|.|:.
Human   579 MFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKT 643

  Fly   805 KCLKVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILV--ALYVIAAVM 867
            :  ......:|::.||:|..:||...:..:::||:|...:     ..:.:|:.|  .|..||:|:
Human   644 E--DTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIF-----RVDPKHLTVNAVLISIASVV 701

  Fly   868 GTLICTHLHVLAKVFVSLFTSHIRVLKRAV----RSSESAPLTMLGAEVAVMTDMVKCLDAFTNQ 928
            |.....:.....:|..||..|..:.|..|.    :......:.:|..||.:|..|.|.:|:||..
Human   702 GLAFVLNCRTWWQVLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQN 766

  Fly   929 QSRLVGVIDALDSCDTERILTLLNAVQTLLSSPNRPFVLLISVDPHVIAKAAEANSRRLFTEGGI 993
            |:|||.:||.||:|:.:::|.:|:.|:.|.|  ..||:.:.:.|||:|.||...|...:..:..|
Human   767 QTRLVVIIDGLDACEQDKVLQMLDTVRVLFS--KGPFIAIFASDPHIIIKAINQNLNSVLRDSNI 829

  Fly   994 GGHDFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSA-RRLSNASE 1057
            .|||::||:|||||:|.:.||...::..:|:     :..||....|  |.|....| ||:|..| 
Human   830 NGHDYMRNIVHLPVFLNSRGLSNARKFLVTS-----ATNGDVPCSD--TTGIQEDADRRVSQNS- 886

  Fly  1058 IISSQEKLRGPARGGGGKKLRLSESVASSTGSNLHRLGQNPQTV-----LDLSRIVLTDDYFSDV 1117
             :....||        |.|..|:.       .:.:|..|..:|:     .||:::::|:|:|||:
Human   887 -LGEMTKL--------GSKTALNR-------RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDI 935

  Fly  1118 NPRSMRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIVLHHDQFMDSNADESVS 1182
            :|::||||:|::.:|.|||:|.||.|:|.||:||||||||||.|.|.::|:.::  .....:.::
Human   936 SPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEE--TEGIPDQMT 998

  Fly  1183 LQSVYEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHKSDLLVADLRIFLPFTINLDPYLRKVL 1247
            |:::||::...:...::..||||:|.|.|..:.||......|:..|:::|||.|:||||.||:::
Human   999 LKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREII 1063

  Fly  1248 KEDQQTIEDEGSLVIQARPSVSNTMRQFP----------APTTY-------------------VP 1283
            .:           |..||..:|.....:|          ||:.|                   |.
Human  1064 AD-----------VRAAREQISIGGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVV 1117

  Fly  1284 SPQA--------------------YPPYQMFQNEYP--ANELRSR-------------NLSTSTE 1313
            |||.                    :.||......||  :..|.||             .|....|
Human  1118 SPQPHSSYYSGMTGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKE 1182

  Fly  1314 PVTPLINSPSDSF-------GDDILQTKLTDLTVEGVISLLDRIEDM-KPALPKLAPVLRENAIN 1370
            .....::||:||.       |..:|   |..|.|:.|...|.:||.: :..||:....:::..||
Human  1183 DAAEGLSSPTDSSRGSGPAPGPVVL---LNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANIN 1244

  Fly  1371 GRVLKHCDMPDLKSVLGLSFGHWELFRLLITTLRECER---------------------LPRKQQ 1414
            ||||..|::.:||..:.::||.|.|||..:..:|..|.                     .|.::.
Human  1245 GRVLAQCNIDELKKEMNMNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRA 1309

  Fly  1415 RQQQQPGALEAPSNVPMIKDVTDALMQ--------PPRESLS------RKNSVSHMEKQ-VTLEE 1464
            ...:.|.. |..|..|...:.:...:.        |...:||      |..|:|.:..| .::|.
Human  1310 SHNELPHT-ELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEI 1373

  Fly  1465 QMICGTLQTLNEEAYEDVAS--------------SERPSPTE---LDTPSAGAAMTTPLLGASG- 1511
            ..:...:|....:||.:..:              |.|.||..   :...|:|.::.:.|....| 
Human  1374 SKLTDKVQAEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGK 1438

  Fly  1512 -SVPAP-SGRESILKQQGSVKADKRVSIQQMATSNNNNNNSTKLTPNVEYVSERQPEVQGAGKRL 1574
             |.|.| .||:|.|.::|.|        ...::|..:.|:::.|.|    ::|...:...:|.:|
Human  1439 DSEPKPDDGRKSFLMKRGDV--------IDYSSSGVSTNDASPLDP----ITEEDEKSDQSGSKL 1491

  Fly  1575 TTKPPPGPRPASLIITRNDSNSQFQL---LRSSSVDYDDVEAQEHRT----TIRTTLLEQQEEEE 1632
            .    ||.:       .::.:|.||.   |:.|.:.|..:.:.|..:    :..|.||:..::.:
Human  1492 L----PGKK-------SSERSSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRK 1545

  Fly  1633 SAPFVFTVRK 1642
            :...|..|.|
Human  1546 AEGKVERVPK 1555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42672NP_726059.5 ANK 169..289 CDD:238125 52/119 (44%)
Ank_2 173..266 CDD:289560 36/92 (39%)
ANK repeat 205..233 CDD:293786 9/27 (33%)
ANK 231..355 CDD:238125 72/124 (58%)
ANK repeat 235..266 CDD:293786 16/30 (53%)
Ank_2 240..332 CDD:289560 50/92 (54%)
ANK repeat 268..299 CDD:293786 17/30 (57%)
ANK repeat 301..332 CDD:293786 18/30 (60%)
Ank_2 306..398 CDD:289560 53/91 (58%)
ANK 329..454 CDD:238125 68/124 (55%)
ANK repeat 334..362 CDD:293786 16/27 (59%)
ANK repeat 367..398 CDD:293786 15/30 (50%)
ANK repeat 400..431 CDD:293786 17/30 (57%)
Ank_4 401..454 CDD:290365 28/52 (54%)
ANK 428..553 CDD:238125 71/124 (57%)
ANK repeat 435..464 CDD:293786 17/28 (61%)
Ank_2 438..530 CDD:289560 52/91 (57%)
ANK repeat 466..497 CDD:293786 16/30 (53%)
ANK repeat 499..530 CDD:293786 18/30 (60%)
Ank_5 518..575 CDD:290568 39/56 (70%)
KAP_NTPase 605..1136 CDD:284995 190/551 (34%)
SAM_superfamily 1357..1392 CDD:188886 12/34 (35%)
KIDINS220NP_001335658.1 ANK 165..290 CDD:238125 68/124 (55%)
ANK 6 170..199 17/28 (61%)
ANK repeat 170..198 CDD:293786 16/27 (59%)
ANK 7 203..232 14/28 (50%)
ANK 231..356 CDD:238125 69/124 (56%)
ANK repeat 236..267 CDD:293786 17/30 (57%)
ANK 8 236..265 15/28 (54%)
ANK repeat 269..299 CDD:293786 16/29 (55%)
ANK 9 269..298 15/28 (54%)
ANK repeat 302..366 CDD:293786 36/63 (57%)
ANK 10 302..331 15/28 (54%)
ANK 11 335..364 17/28 (61%)
Ank_4 338..389 CDD:316185 29/50 (58%)
ANK 12 368..397 17/28 (61%)
KAP_NTPase 441..954 CDD:284995 190/551 (34%)
Mediates interaction with CRKL. /evidence=ECO:0000250|UniProtKB:Q9EQG6 1090..1093 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1203 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1286..1311 1/24 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1345..1369 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1398..1565 39/181 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1634
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1714..1772
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9EQG6 1767..1772
ANK 1 4..33 6/29 (21%)
ANK 32..191 CDD:238125 84/158 (53%)
ANK 2 37..66 9/28 (32%)
ANK repeat 38..68 CDD:293786 9/29 (31%)
ANK repeat 70..101 CDD:293786 16/30 (53%)
ANK 3 70..99 14/28 (50%)
ANK repeat 103..132 CDD:293786 17/28 (61%)
ANK 4 103..132 17/28 (61%)
ANK 5 137..166 17/28 (61%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 291 1.000 Domainoid score I1552
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H14254
Inparanoid 1 1.050 882 1.000 Inparanoid score I405
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46561
OrthoDB 1 1.010 - - D38210at33208
OrthoFinder 1 1.000 - - FOG0006003
OrthoInspector 1 1.000 - - oto89161
orthoMCL 1 0.900 - - OOG6_106563
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4301
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.880

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