DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42672 and ANKRD50

DIOPT Version :9

Sequence 1:NP_726059.5 Gene:CG42672 / 37433 FlyBaseID:FBgn0261554 Length:1642 Species:Drosophila melanogaster
Sequence 2:NP_065070.1 Gene:ANKRD50 / 57182 HGNCID:29223 Length:1429 Species:Homo sapiens


Alignment Length:505 Identity:151/505 - (29%)
Similarity:223/505 - (44%) Gaps:96/505 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 IDDRDENATTVLMVVAGRGLTAFVREFLARGADVQAEDLDNWTAL----LCA-SRNGHLDVVQLL 255
            ::..|....|.|:..|..|....|...|..||:|..||:|..|||    ||. :..||..||.||
Human   670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734

  Fly   256 LDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGADGNAHGNYHLGALLWAAGRGYKDIVEL 320
            :|.||||:|.|..|.|.|:.|||.||.::|.|||:.|||.:...|.....||.||..|:..:|..
Human   735 IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799

  Fly   321 LVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGANV---DTAGMYSWTPL---------- 372
            |:..||.|:..|..|.|.|..|..:||||:|.|||..|.:.   |.||   ||||          
Human   800 LLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG---WTPLHMAAFEGHRL 861

  Fly   373 -----------------------LVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQ 414
                                   ::|:..||.|||..:||.|.|::....||..||.:|:.||.:
Human   862 ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926

  Fly   415 DIAASLIAAGAYINIQDR-GADTPLIHAVK--------------------------------AGH 446
            ||...|.:.||.:|.:|. |..|..|.|::                                .||
Human   927 DIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991

  Fly   447 RTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNR 511
            ..:|:.|:..||||:....::::|:.:|..:||..:|:||:.....::.....|.|.|..|.:..
Human   992 MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056

  Fly   512 NLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALLRNPKHSQLLYRANKAGETPYN-- 574
            ::::|.:||:..|....:|:.|.|    |||..:|.         .|||::....|.|.:..|  
Human  1057 HIDVVQVLLEHGADPNHADQFGRT----AMRVAAKN---------GHSQIIKLLEKYGASSLNGC 1108

  Fly   575 ----IDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSEPT 620
                :.::.||.:.......:.|....:|.|..|......:|..:.:.||
Human  1109 SPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPT 1158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42672NP_726059.5 ANK 169..289 CDD:238125 41/97 (42%)
Ank_2 173..266 CDD:289560 30/74 (41%)
ANK repeat 205..233 CDD:293786 9/27 (33%)
ANK 231..355 CDD:238125 58/128 (45%)
ANK repeat 235..266 CDD:293786 18/35 (51%)
Ank_2 240..332 CDD:289560 42/96 (44%)
ANK repeat 268..299 CDD:293786 15/30 (50%)
ANK repeat 301..332 CDD:293786 10/30 (33%)
Ank_2 306..398 CDD:289560 41/127 (32%)
ANK 329..454 CDD:238125 52/193 (27%)
ANK repeat 334..362 CDD:293786 13/30 (43%)
ANK repeat 367..398 CDD:293786 14/63 (22%)
ANK repeat 400..431 CDD:293786 13/30 (43%)
Ank_4 401..454 CDD:290365 20/85 (24%)
ANK 428..553 CDD:238125 36/157 (23%)
ANK repeat 435..464 CDD:293786 11/60 (18%)
Ank_2 438..530 CDD:289560 25/123 (20%)
ANK repeat 466..497 CDD:293786 7/30 (23%)
ANK repeat 499..530 CDD:293786 8/30 (27%)
Ank_5 518..575 CDD:290568 16/62 (26%)
KAP_NTPase 605..1136 CDD:284995 3/16 (19%)
SAM_superfamily 1357..1392 CDD:188886
ANKRD50NP_065070.1 AAA_16 22..195 CDD:289934
Cas9_REC <221..>352 CDD:293200
ANK 1 477..509
ANK <495..598 CDD:238125
ANK 2 511..540
Ank_5 531..585 CDD:290568
ANK repeat 544..575 CDD:293786
ANK 3 544..573
ANK 573..697 CDD:238125 6/26 (23%)
ANK repeat 577..608 CDD:293786
ANK 4 577..606
Ank_2 582..674 CDD:289560 0/3 (0%)
ANK repeat 610..641 CDD:293786
ANK 5 610..639
ANK repeat 643..674 CDD:293786 0/3 (0%)
ANK 6 643..672 0/1 (0%)
Ank_2 648..745 CDD:289560 30/74 (41%)
ANK repeat 676..707 CDD:293786 9/30 (30%)
ANK 7 676..705 9/28 (32%)
ANK repeat 709..745 CDD:293786 18/35 (51%)
ANK 8 709..743 17/33 (52%)
ANK 742..867 CDD:238125 49/127 (39%)
ANK repeat 747..778 CDD:293786 15/30 (50%)
ANK 9 747..776 15/28 (54%)
Ank_2 752..844 CDD:289560 38/91 (42%)
ANK repeat 780..811 CDD:293786 10/30 (33%)
ANK 10 780..809 10/28 (36%)
ANK 808..932 CDD:238125 40/126 (32%)
ANK repeat 813..844 CDD:293786 13/30 (43%)
ANK 11 813..842 13/28 (46%)
ANK 12 846..875 6/31 (19%)
ANK repeat 847..877 CDD:293786 5/32 (16%)
Ank_2 851..943 CDD:289560 24/91 (26%)
ANK repeat 879..910 CDD:293786 10/30 (33%)
ANK 13 879..908 10/28 (36%)
ANK repeat 912..943 CDD:293786 13/30 (43%)
ANK 14 912..941 12/28 (43%)
ANK repeat 945..976 CDD:293786 4/30 (13%)
ANK 15 945..974 4/28 (14%)
Ank_4 946..999 CDD:290365 7/52 (13%)
ANK 974..1097 CDD:238125 33/135 (24%)
ANK repeat 978..1009 CDD:293786 8/30 (27%)
ANK 16 978..1007 8/28 (29%)
Ank_2 983..1075 CDD:289560 23/91 (25%)
ANK repeat 1011..1042 CDD:293786 7/30 (23%)
ANK 17 1011..1040 7/28 (25%)
ANK repeat 1044..1075 CDD:293786 8/30 (27%)
ANK 18 1044..1073 8/28 (29%)
Ank_2 1049..>1110 CDD:289560 19/73 (26%)
ANK 19 1077..1107 11/42 (26%)
ANK repeat 1077..1102 CDD:293786 10/37 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1108..1200 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1217..1296
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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