DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42672 and kidins220a

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_009291458.1	Gene:	kidins220a / 570732	ZFINID:	ZDB-GENE-041014-170	Length:	1713	Species:	Danio rerio

Alignment Length:	1656	Identity:	568/1656 - (34%)
Similarity:	861/1656 - (51%)	Gaps:	258/1656 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 MGSLGHRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADV 229
            |.||..::|..|::..::|.::|.|| ::..:|.|.||..|.||:.:.:|....|:|.:.|||::
Zfish     9 MNSLSTQSLFSYVEEENLSAIKAHLD-KYREVDTRSENGQTALMLASEQGSLEIVQELIRRGANI 72

  Fly   230 QAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGAD 294
            ..:|:|.||||:.|::.||.|||:.||::.|.|||||||||::||||||:|..|:..|||:|||:
Zfish    73 HLDDIDCWTALISAAKEGHTDVVKELLENNANVEHRDMGGWSALMWAAYKGRVEVAGLLLEKGAN 137

  Fly   295 GNAHGNYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGA 359
            .|..|.|.:..::||||||:.:||:||:|..||||..||||||.|:||.|:|:.:.|..||:.||
Zfish   138 PNITGQYSVYPIIWAAGRGHAEIVQLLLQHEAKVNCSDKYGTTPLIWASRKGHYDCVMHLLENGA 202

  Fly   360 NVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAAG 424
            |||..|..|.|.|:||..||.|:.|..:|::.||||..||||.|||.||:.||:.:|...|:.||
Zfish   203 NVDQEGANSMTALIVAVRGGFTEVVKELLKRNPNVNMTDKDGNTALMIAAIEGYTEIVQDLLDAG 267

  Fly   425 AYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLAT 489
            .|:||.||..||.||.||:.||..:|.|||.|:||:|::|:|.|||:|.|||||:..:|:.:|..
Zfish   268 TYVNIPDRSGDTVLIGAVRGGHVEIVRALLNKYADIDVKGQDGKTALYWAVEKGNATMVRDILQC 332

  Fly   490 NPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALLR 554
            |||.|:.|||.:|||::|.:.||:|||.||||:.|||:|.||:|||.||||:|.||:.:.|.|||
Zfish   333 NPDTEAYTKDAETPLIKATKMRNMEIVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 397

  Fly   555 NPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSEP 619
            |||..:||||.||.||||||||..|||:||.|:|||:.|:.:|....||||:||||||||:||||
Zfish   398 NPKDGRLLYRPNKEGETPYNIDCTHQKSILTQIFGAKHLSPSECDGDMLGYDLYSSALADILSEP 462

  Fly   620 TLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEPPIRTSGLL----FIVCLHVALLIGTI 680
            |:..||.|||||:|||||||||.||.|||..||.|..||..:.|.|:    .::|..|||::|..
Zfish   463 TMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQVEPLFQFSWLVVVLTLLLCGSVALVLGFA 527

  Fly   681 VGLSTWSAVVGVSAAVGFLLLAYLLLAAVRYCNYQM--DMQWAYSVQHGLEKRMTRLRLILQVAF 743
            |     ...:.::.|:..|.|.|:....|.:...:.  ...||:.:...|.:.:..|.|:|::.|
Zfish   528 V-----DTKLAIAVALTLLALMYIFFVLVYFGGRKAGESWSWAWVLSTRLARHIGYLELLLKLMF 587

  Fly   744 CHPPG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRPKC 806
            .:||. |:..::|.||||.|.:.|..|.. |:.::|.|:|.|.||.|..:|:|||||:|.|:...
Zfish   588 VNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKNDE 652

  Fly   807 LKVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILVALYVIAAVMGTLI 871
            .:   |.:|::.||:|..::|.|....::||::|..   .|..:.|...:...|..:|:|:|..:
Zfish   653 AQ---GKKWKKTCCVPSFVLFVLTSGCLITGMALLA---IFKVDSENLTVNAVLISMASVVGLAL 711

  Fly   872 CTHLHVLAKVFVSLFTSHIRVLKRAVR-----SSESAPLTMLGAEVAVMTDMVKCLDAFTNQQSR 931
            ..:.....:|..|:..|..|.|..|..     .||.. :.:|..||.:|..|.|.:|:||..|:|
Zfish   712 LLNCRTWWQVADSVLHSQRRRLLNAANRMHKLKSEGF-MKVLKCEVELMAKMAKTIDSFTQNQTR 775

  Fly   932 LVGVIDALDSCDTERILTLLNAVQTLLSSPNRPFVLLISVDPHVIAKAAEANSRRLFTEGGIGGH 996
            |..:||.||||:.:::|.:|:.|:.|.|  ..||:.:.:.|||:|.||...|...:..:..|.||
Zfish   776 LAVIIDGLDSCEQDKVLQMLDTVRVLFS--KGPFISIFASDPHIIIKAINQNLNSVLRDSNINGH 838

  Fly   997 DFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSARRLSNASEIISS 1061
            |::||::||||:|.:.||...:|     |....:..|               |.:|:|.:.....
Zfish   839 DYMRNIIHLPVFLNSRGLSTAKR-----LCISTAANG---------------ADQLNNDAWQEDV 883

  Fly  1062 QEKLRGPARGGGGKKLRLSESVASSTGSN---LHRLGQNPQTV-----LDLSRIVLTDDYFSDVN 1118
            ..||...:.|..|::       .|.|..|   .:|..|..::|     .||:::::|:|:|||::
Zfish   884 DRKLSQNSLGDQGRQ-------GSKTALNRRDTYRRRQMQRSVTRQMSFDLTKLLVTEDWFSDIS 941

  Fly  1119 PRSMRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIVLHHDQFMDSNADESVSL 1183
            |::||||:|::.:|.|||:|.||.|:|.||:|||||||:||.|.|.|:|..::  .....:.|:|
Zfish   942 PQTMRRLLNIVSVTGRLLRANQIIFNWDRLASWINLTEEWPYRTSWIILFLEE--TDGVTDLVTL 1004

  Fly  1184 QSVYEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHKSDLLVADLRIFLPFTINLDPYLRKVLK 1248
            :::||::...:...::..||||:|.|.|..:.||..|...|...|:.:|||.|:||||.||:::.
Zfish  1005 KTIYERISKNIPTTKDVEPLLEIDGDIRSFEVFLSSHTPVLTARDVEMFLPCTVNLDPKLREIIA 1069

  Fly  1249 EDQQTIEDE--GSLVIQARPSVSNTMR----------------QFPA--------PTT------- 1280
            :.:...|..  |.:.....|....::|                .||.        |.|
Zfish  1070 DVRDAREQMHLGGVSFPTLPLQDASVRPHSGFGQQSLACSPTGSFPGSFPNAGVLPATQPHSSYF 1134

  Fly  1281 --------------YVPS-----PQAYPPYQMFQNEYPANELR--------------SRNLSTST 1312
                          |.|.     |:.||.:.......||::|.              |..|.:.|
Zfish  1135 SGLTGPQHPFYNRPYFPHHVYHLPRNYPGHPHHAPTRPASKLHKDPGLGLDVIREDSSEGLPSPT 1199

  Fly  1313 EPVTPLINSPS--------DSFGDDILQTKLTDLTVEGVISLLDRIEDMKPA-LPKLAPVLRENA 1368
            .|  .:|.|..        .|.|..:|   |:.||::||...|.:|:.:..: |.:....:::..
Zfish  1200 SP--SMIKSQPFRMKQGSVVSSGSQVL---LSSLTIDGVCEKLRQIQGLDSSMLEQYIGTIKKAN 1259

  Fly  1369 INGRVLKHCDMPDLKSVLGLSFGHWELFRLLITTLRECERLPRKQQRQQQQPGALEAPSNVPMIK 1433
            :|||||..|::.:||..:.::||.|.|||..:...|..|     .|....:.||.....:..:|:
Zfish  1260 VNGRVLSQCNLDELKKEMNMNFGDWHLFRSTVVEQRHAE-----NQLLHDESGACSEQGSSVLIQ 1319

  Fly  1434 DVTDALMQPPRESLSRKNSVSHMEK-----QVTLEEQMICG--------------------TLQT 1473
            .      :|.|.|.:|::...:.|.     .::.||....|                    :|.:
Zfish  1320 P------EPHRPSEARQDVTVNPENFTYSLNLSFEELSGVGLEESARQHNAHWLANTHRTPSLSS 1378

  Fly  1474 LNEE-------------------AYEDVASSERPSPTELDTPSAG-----AAMTTPLLGASGSVP 1514
            ||.:                   ||::..|    ..:.|:..:||     .|:::.||..|....
Zfish  1379 LNSQESSNDICKLTDKQQAEYHSAYQEYIS----HMSHLEASAAGRESQTQALSSQLLSTSSEDK 1439

  Fly  1515 APSGRESILK---QQGSVKADKRVSIQQMATS-----------NNNNNNSTKLTPNVE------- 1558
            ...|.:...|   ::|....|..........|           .:::.::||..|..:
Zfish  1440 IKEGDQDGRKPFGKKGPKPTDTMADFSSPPDSGLLDPITEEDEKSDHGSATKNPPRRKTKGQGPY 1504

  Fly  1559 YVSERQPEVQGAGKRLTTKP-----PPGPRP------------ASLIITRNDSNSQFQLLRSSSV 1606
            |.|....|.....:.....|     |.|..|            :.:::.:..|:|..:..||||
Zfish  1505 YHSLPSDEDDSGDEETDATPLLKDEPWGAEPDLDHLSKGKGFVSDIMLDKKSSDSGVRSSRSSS- 1568

  Fly  1607 DYDDVEAQEHRTTIRTTLLEQQEEEESAPFV 1637
               |...|:...       |::.||:.|..:
Zfish  1569 ---DHSLQDEEK-------EEKSEEQEAQLI 1589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	52/119 (44%)
		Ank_2	173..266	CDD:289560	37/92 (40%)
		ANK repeat	205..233	CDD:293786	9/27 (33%)
		ANK	231..355	CDD:238125	68/123 (55%)
		ANK repeat	235..266	CDD:293786	17/30 (57%)
		Ank_2	240..332	CDD:289560	51/91 (56%)
		ANK repeat	268..299	CDD:293786	18/30 (60%)
		ANK repeat	301..332	CDD:293786	16/30 (53%)
		Ank_2	306..398	CDD:289560	49/91 (54%)
		ANK	329..454	CDD:238125	65/124 (52%)
		ANK repeat	334..362	CDD:293786	15/27 (56%)
		ANK repeat	367..398	CDD:293786	14/30 (47%)
		ANK repeat	400..431	CDD:293786	16/30 (53%)
		Ank_4	401..454	CDD:290365	27/52 (52%)
		ANK	428..553	CDD:238125	70/124 (56%)
		ANK repeat	435..464	CDD:293786	16/28 (57%)
		Ank_2	438..530	CDD:289560	51/91 (56%)
		ANK repeat	466..497	CDD:293786	16/30 (53%)
		ANK repeat	499..530	CDD:293786	18/30 (60%)
		Ank_5	518..575	CDD:290568	38/56 (68%)
		KAP_NTPase	605..1136	CDD:284995	187/551 (34%)
		SAM_superfamily	1357..1392	CDD:188886	10/34 (29%)
kidins220a	XP_009291458.1	ANK	40..165	CDD:238125	63/124 (51%)
		ANK repeat	45..76	CDD:293786	10/30 (33%)
		Ank_2	50..141	CDD:289560	47/90 (52%)
		ANK repeat	78..109	CDD:293786	17/30 (57%)
		ANK repeat	112..142	CDD:293786	17/29 (59%)
		ANK repeat	144..175	CDD:293786	16/30 (53%)
		Ank_2	149..241	CDD:289560	49/91 (54%)
		ANK	172..297	CDD:238125	65/124 (52%)
		ANK repeat	177..205	CDD:293786	15/27 (56%)
		ANK repeat	210..241	CDD:293786	14/30 (47%)
		Ank_2	215..306	CDD:289560	48/90 (53%)
		ANK	238..363	CDD:238125	67/124 (54%)
		ANK repeat	243..274	CDD:293786	16/30 (53%)
		ANK repeat	276..306	CDD:293786	16/29 (55%)
		Ank_2	281..373	CDD:289560	51/91 (56%)
		ANK repeat	309..373	CDD:293786	36/63 (57%)
		Ank_5	362..418	CDD:290568	37/55 (67%)
		KAP_NTPase	448..959	CDD:284995	187/551 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	871	1.000	Inparanoid score	I396
OMA	1	1.010	-	-		QHG46561
OrthoDB	1	1.010	-	-		D38210at33208
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		otm26321
orthoMCL	1	0.900	-	-		OOG6_106563
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880