DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42672 and kidins220b

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	XP_005160694.1	Gene:	kidins220b / 335881	ZFINID:	ZDB-GENE-030131-7824	Length:	1732	Species:	Danio rerio

Alignment Length:	1615	Identity:	559/1615 - (34%)
Similarity:	858/1615 - (53%)	Gaps:	243/1615 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 MGSLGHRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADV 229
            |.:|..:.|..|::..:::.::..|| :...:|.|.:|..|.||:.:.:|....|:|.:.|||:|
Zfish     9 MTTLAIQNLFSYVEEENLAAVKVHLD-KFKEVDGRSDNGQTPLMLASEQGSLEIVQELIRRGANV 72

  Fly   230 QAEDLDNWTALLCASRNGHLDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLLDKGAD 294
            ..:|:|.|:||:.|::.||::||:.||::.|.:|||||||||:|.||:|:|..|:..:||:.||:
Zfish    73 NLDDVDCWSALISAAKEGHVEVVKELLENSAYIEHRDMGGWTALTWASYKGRVEVATVLLENGAN 137

  Fly   295 GNAHG-NYHLGALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAG 358
            .|..| .|.:..::||||||:.:||:||::.|||||..||||||.|:||.|:|:.:.|..||:.|
Zfish   138 PNTTGQQYSVYPIIWAAGRGHAEIVKLLLEHGAKVNCSDKYGTTPLIWAARKGHYDCVMHLLENG 202

  Fly   359 ANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAA 423
            |:||..|..|.|.|:||..||:|:.|..:|::.||||..||||.|||.||::||:.:|...|:.|
Zfish   203 ADVDQEGANSMTALIVAVKGGYTEVVKELLKRNPNVNMTDKDGNTALMIAAKEGYTEIVQDLLDA 267

  Fly   424 GAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLA 488
            |.|:||.||..||.||.||:.||..:|.|||.|:||:||:|::.|||:|.|||||:..:|:.:|.
Zfish   268 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLHKYADIDIRGQENKTALYWAVEKGNATMVRDILQ 332

  Fly   489 TNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARSKTIVEALL 553
            .:||.|:.|||.:|||::|.:.|::|:|.||||:.|||:|.||||||.||||:|.||:.:.|.||
Zfish   333 CSPDTETTTKDSETPLIKATKMRSIEVVELLLDKGAKVSAVDKRGDTPLHIAIRGRSRRLAELLL 397

  Fly   554 RNPKHSQLLYRANKAGETPYNIDSLHQKTILGQVFGARRLNTNEDSEGMLGYELYSSALADVLSE 618
            ||||..:||||.|||||||||||..|||:||.|:||||.|:..|....||||:||||||||:|||
Zfish   398 RNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSE 462

  Fly   619 PTLTTPITVGLYAKWGSGKSFLLNKLRDEMNNFARQWAEPPIRTSGLL----FIVCLHVALLIGT 679
            ||:..||.|||||:|||||||||.||.|||..||.|..||..:.|.|:    .::|..|||::|.
Zfish   463 PTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQVEPLFQFSWLVVLLSLLLCGSVALVLGF 527

  Fly   680 IVGLSTWSAVVGVSAAVGFLLLAYLLLAAVRYCNYQ--MDMQWAYSVQHGLEKRMTRLRLILQVA 742
            .|     ...:.::.::..|.|.|:....|.:.:.:  ....||:.:...|.:.:..|.|:|::.
Zfish   528 TV-----DPKLAIAISLSILALLYVFFVVVYFGSRREGESWNWAWVISTRLARHIGYLELLLKLM 587

  Fly   743 FCHPPG-PQSDSQAKPVRFHFAEANSASPT-GDGAVAHMLAALLDAIESHYGWLATRLYRAFRPK 805
            |.:||. |:..::|.||||.|.:.|..|.. |:.::|.|:|.|.||.|..:|:|||||:|.|:.:
Zfish   588 FVNPPELPEQTTRALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKTE 652

  Fly   806 CLKVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILVALYVIAAVMGTL 870
              ......:|::.||||..:||...|..::.|::|...:......:....:||::   |:|:|..
Zfish   653 --DTQGKKKWKKTCCIPSFVIFLFILGCLIMGMALLAVFKVDGQNQTVNAVLVSM---ASVVGLA 712

  Fly   871 ICTHLHVLAKVFVSLFTSHIRVLKRAVRSSESAP----LTMLGAEVAVMTDMVKCLDAFTNQQSR 931
            :..:.....:|..|:..|..:.|..|........    :.:|..||.:|..|.|.:|.||..|:|
Zfish   713 LLLNCRTWWQVTDSVLNSQRKRLHSAANKMHKLKSEGFMKVLKNEVELMAKMAKTIDGFTQNQTR 777

  Fly   932 LVGVIDALDSCDTERILTLLNAVQTLLSSPNRPFVLLISVDPHVIAKAAEANSRRLFTEGGIGGH 996
            ||.:||.||||:.:::|.:|:.|:.|.|  ..||:.:.:.|||:|.||...|...:..:..|.||
Zfish   778 LVVIIDGLDSCEQDKVLQMLDTVRVLFS--KGPFISIFASDPHIIIKAINQNLNSVLRDSNINGH 840

  Fly   997 DFLRNLVHLPVYLQNSGLRKVQRAQMTALLFKRSGGGDYQTDDGPTLGHSVSARRLSNASEIISS 1061
            |::||:|||||:|.:.||...::....|     ...|:....:|   .|....|:||..|  :..
Zfish   841 DYMRNIVHLPVFLNSRGLSSAKKMCAPA-----PANGETGNSEG---WHEELDRKLSQNS--LGD 895

  Fly  1062 QEKLRGPARGGGGKKLRLSESVASSTGSNLHRLGQNPQTV-----LDLSRIVLTDDYFSDVNPRS 1121
            |.|.        |.|..|:.       .:.:|..|..::|     .||:::::|:|:|||::|::
Zfish   896 QTKF--------GSKTTLNR-------RDTYRRRQMQRSVTRQMSFDLTKLLVTEDWFSDISPQT 945

  Fly  1122 MRRLMNVIYITVRLLKAFQIEFSWYRLSSWINLTEQWPLRASMIVLHHDQFMDSNADESVSLQSV 1186
            ||||:|::.:|.|||:|.||.|:|.||:||||||||||.|.|.::|:.:: .|...|:: :|:::
Zfish   946 MRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEE-TDGIPDQT-NLKTI 1008

  Fly  1187 YEKLRPKLAYLREAAPLLELDRDERKLDAFLQLHKSDLLVADLRIFLPFTINLDPYLRKVLKEDQ 1251
            ||::...:...::..||||:|.|.|..:.||......|...|:|.|||.|:||||.||:::.:.:
Zfish  1009 YERISKNIPTTKDVEPLLEIDGDVRSFEVFLSSRTPVLAARDIRTFLPCTVNLDPKLREIIADVR 1073

  Fly  1252 QTIEDEG-------SLVIQARPSVSNTMRQFPA--PTT-----YVP---SPQ------------- 1286
            ...|...       :|.:|....:|...:|..|  ||.     |.|   |||
Zfish  1074 AAREQVNMAGVTYPTLPLQEGRPISMYSQQSSACSPTASFNGPYNPPGVSPQPHSAYFSGMAGPQ 1138

  Fly  1287 ------AYPPYQMFQ-------NEYPAN------------------------ELRSRNLSTSTEP 1314
                  .|.|..::|       :.:||:                        .|:.:..|.|...
Zfish  1139 HPFYNRPYFPQHLYQLPRQFTGSYFPAHVLHRPFIKSGYPKDPSSGLQGKVPSLKKKQGSASVVS 1203

  Fly  1315 VTPLINSPSDSFGDDILQTKLTDLTVEGVISLLDRIEDMKPALPKLAPVLRENAINGRVLKHCDM 1379
            .||.|          :|.:..||:..|.| .|:|.|:  :..:.:....:::..||||||..|::
Zfish  1204 GTPSI----------LLSSMSTDVICERV-KLIDGID--QNLISQYTATIKKANINGRVLSQCNI 1255

  Fly  1380 PDLKSVLGLSFGHWELFRLLITTLRECERLPRKQQRQQQQ-------------PGA--------- 1422
            .:||..:.::||.|:|||..:..:|..|.....::...:|             .||
Zfish  1256 DELKKEMNMNFGDWQLFRTSVLEMRHVENQVLHEEAPSEQGSITVGHVEPCRHAGAAAQGVAGNT 1320

  Fly  1423 -----------LEAPSNVPMIKDVTDALMQPPRE-------SLSRKNSVSHMEKQVTLEEQMICG 1469
                       .|..|||        .|.:|||.       :..|..|:|.:..|.:..|  ||.
Zfish  1321 DTSPMYNFNLSFEELSNV--------GLEEPPRHVNATWMGTTHRTPSMSSLNSQESSNE--ICK 1375

  Fly  1470 TLQTLNEE---AYEDVASS--------ERPSPTELDTPSAGAAMTTPLLGASGSVPAPSGRESIL 1523
            .......|   ||||..:|        |:|.|          ...:.|:.:|.......|.:
Zfish  1376 LTDKQQAEYRNAYEDYIASMSQLELGMEKPVP----------PFVSQLMHSSSEDKKKDGND--- 1427

  Fly  1524 KQQGSVKADKRVSIQQMATSNNNNNNSTKLTPNVEYVSERQPEV-QGAGKRLTTKPPPGPRPASL 1587
             |.|.....||.|.:   :.::|.:.::.....::.::|...:| .|:.|.|..:...|.: .||
Zfish  1428 -QDGRKSVSKRGSTK---SGSDNTDYASADAATLDPITEEDEKVDHGSSKSLLGRKTSGDK-VSL 1487

  Fly  1588 -----IITRNDSNSQFQLLRSSSVDYDDVEAQEHRTTIRTTLLEQQEEEESAPFV 1637
                 :..:....|::|.|.|     ||               |:.||.::||.:
Zfish  1488 FQGADLKLKAGGGSRYQKLTS-----DD---------------EESEESDNAPLL 1522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	45/119 (38%)
		Ank_2	173..266	CDD:289560	32/92 (35%)
		ANK repeat	205..233	CDD:293786	10/27 (37%)
		ANK	231..355	CDD:238125	62/124 (50%)
		ANK repeat	235..266	CDD:293786	14/30 (47%)
		Ank_2	240..332	CDD:289560	46/92 (50%)
		ANK repeat	268..299	CDD:293786	15/30 (50%)
		ANK repeat	301..332	CDD:293786	16/30 (53%)
		Ank_2	306..398	CDD:289560	48/91 (53%)
		ANK	329..454	CDD:238125	64/124 (52%)
		ANK repeat	334..362	CDD:293786	14/27 (52%)
		ANK repeat	367..398	CDD:293786	14/30 (47%)
		ANK repeat	400..431	CDD:293786	16/30 (53%)
		Ank_4	401..454	CDD:290365	27/52 (52%)
		ANK	428..553	CDD:238125	68/124 (55%)
		ANK repeat	435..464	CDD:293786	17/28 (61%)
		Ank_2	438..530	CDD:289560	48/91 (53%)
		ANK repeat	466..497	CDD:293786	14/30 (47%)
		ANK repeat	499..530	CDD:293786	16/30 (53%)
		Ank_5	518..575	CDD:290568	40/56 (71%)
		KAP_NTPase	605..1136	CDD:284995	184/547 (34%)
		SAM_superfamily	1357..1392	CDD:188886	10/34 (29%)
kidins220b	XP_005160694.1	Ank_4	17..66	CDD:290365	13/49 (27%)
		ANK	40..199	CDD:238125	75/158 (47%)
		ANK repeat	45..76	CDD:293786	11/30 (37%)
		Ank_2	50..141	CDD:289560	42/90 (47%)
		ANK repeat	78..109	CDD:293786	14/30 (47%)
		ANK repeat	111..139	CDD:293786	14/27 (52%)
		ANK repeat	149..176	CDD:293786	15/26 (58%)
		Ank_2	150..242	CDD:289560	48/91 (53%)
		ANK	173..298	CDD:238125	64/124 (52%)
		ANK repeat	178..209	CDD:293786	16/30 (53%)
		ANK repeat	211..242	CDD:293786	14/30 (47%)
		Ank_2	216..307	CDD:289560	48/90 (53%)
		ANK	239..397	CDD:238125	85/157 (54%)
		ANK repeat	244..275	CDD:293786	16/30 (53%)
		ANK repeat	277..308	CDD:293786	17/30 (57%)
		ANK repeat	310..374	CDD:293786	32/63 (51%)
		Ank_2	315..402	CDD:289560	48/86 (56%)
		KAP_NTPase	449..960	CDD:284995	184/547 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14254
Inparanoid	1	1.050	871	1.000	Inparanoid score	I396
OMA	1	1.010	-	-		QHG46561
OrthoDB	1	1.010	-	-		D38210at33208
OrthoFinder	1	1.000	-	-		FOG0006003
OrthoInspector	1	1.000	-	-		otm26321
orthoMCL	1	0.900	-	-		OOG6_106563
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3637
SonicParanoid	1	1.000	-	-		X4301
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910