DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42672 and ANKRD28

DIOPT Version :9

Sequence 1:	NP_726059.5	Gene:	CG42672 / 37433	FlyBaseID:	FBgn0261554	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_001336206.1	Gene:	ANKRD28 / 23243	HGNCID:	29024	Length:	1086	Species:	Homo sapiens

Alignment Length:	1031	Identity:	232/1031 - (22%)
Similarity:	359/1031 - (34%)	Gaps:	292/1031 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 IEEETDAAVAAAEGKSSPAPNQEHEEHSNQSPSRRFSHFNLALRRFSHIHAHNINRFGDSMGSLG 169
            :|:|:.|.:       |..|.:....||..|.       |:.:|
Human    12 VEDESPAFI-------SKLPQENKSLHSPPSG-------NVLVR--------------------- 41

  Fly   170 HRALLQYIDNNDISGLRAILDSRHLTIDDRDENATTVLMVVAGRGLTAFVREFLARGADVQAEDL 234
            :.:|:|.|.|.|...:||::..:. .::.:|....|.|...|..|....:...:..||.|.|:|.
Human    42 YPSLVQAIFNGDPDEVRALIFKKE-DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDS 105

  Fly   235 DNWTALLCASRNGHLDVVQLLLDHGAEVEHR---------------------------------D 266
            ...|.|..|..:...:.||:||.|.|:|..|                                 |
Human   106 KWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 170

  Fly   267 MGGWTSLMWAAYRGHTELVRLLLDKGADGNAHGNYHLGALLWAAGRGYKDIVELLVQRGAKVNVG 331
            ..|.|:|..||:.||.|:|:|||.:||:.||.......|:.|||..|:.::|:|||..||:|...
Human   171 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 235

  Fly   332 DK---------------------------------YGTTALVWACRRGNVEIVDTLLKAGANVDT 363
            ||                                 ||.|.|..||..|...:|:.|:..||.|:.
Human   236 DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 300

  Fly   364 AGMYSWTPLLVAAAGGH-TDCVSSILEKKPNVNALDKDGMTALCIASREGFQDIAASLIAAGAYI 427
            .....:|||..|||..| ..|:..::....:||...|||.|.|.:.:..|....:.::|.:||.|
Human   301 KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 365

  Fly   428 NIQDRGADTPLIHAVKAGHRTVVEALLKKHADV-------------------------------D 461
            :.:|:..:|||..|.:.||..::..|:...||.                               |
Human   366 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD 430

  Fly   462 IQGKD--RKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKA 524
            |...|  .:|.::.|...|:...:.|||.|..|.....|.|.:||..|..|.|.:.:..|:...|
Human   431 IDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 495

  Fly   525 KVTASDKRGDTCLHIAMRARSKT---IVEALLRNPKHSQLLYRANKAGETPYNIDSLHQKTILGQ 586
            .|...|:||.|.||.|  |.|.|   .:|.||||..:..:   .:|.|   ||  ::|.....|.
Human   496 SVNDLDERGCTPLHYA--ATSDTDGKCLEYLLRNDANPGI---RDKQG---YN--AVHYSAAYGH 550

  Fly   587 VFGARRLNTNEDSEGMLGYELYSSAL-ADVLSEPTLTTPITVGLYAKWGSGKSFLLNKLRDEMNN 650
                           .|..:|.:|.. .|||.|.:.|                   :.|.|..|.
Human   551 ---------------RLCLQLIASETPLDVLMETSGT-------------------DMLSDSDNR 581

  Fly   651 FARQWAEPPIRTSGLLFIVCLH-----VALLIGTIVGL----STWSAVVGVSAAVGFLLLAYLLL 706
                      .|...|.:...|     :.:|:.:::.|    |:....:.::|..|.:....:|:
Human   582 ----------ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 636

  Fly   707 ---AAVRYCNYQMDMQWAYSVQHGLEKRMTRLRLILQVAFCHPPGPQSDSQAKPVRFHFAEANSA 768
               |::...:|                       ||:....|.......|:...:....||..:|
Human   637 NQGASILVKDY-----------------------ILKRTPIHAAATNGHSECLRLLIGNAEPQNA 678

  Fly   769 --SPTGDGAVAHMLAALLDAIESHYG-------------WLATRLYRA--------------FRP 804
              ...|:|....||:.|....:..|.             |..|.|:|.              ...
Human   679 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 743

  Fly   805 KCLKVDVGWRWRRMCCIPIVLIFELALVTVVTGISLTVAYFTFADEKEKEHILVALYVIAAVMGT 869
            |||..|...|      .||.|......:.|:..:..:.|...........|...||: .|...|.
Human   744 KCLLRDSRGR------TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALH-WACYNGH 801

  Fly   870 LICTHLHVLAKVFVSLFTSHIRVLKRAVRSSESAPLTM----LGAEV--------------AVMT 916
            ..|..|.:..:||.....:....|..||.:.......|    |||.:              |..|
Human   802 ETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT 866

  Fly   917 DMVKCLDAFTNQQSRLVGVIDALDSCDTERILTL-----LNAVQTLLSSPNRPFVL 967
            |.|:||....:..::    ::::||.....::..     .|.|:.|:||.:....|
Human   867 DHVECLQLLLSHNAQ----VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42672	NP_726059.5	ANK	169..289	CDD:238125	39/152 (26%)
		Ank_2	173..266	CDD:289560	28/125 (22%)
		ANK repeat	205..233	CDD:293786	8/27 (30%)
		ANK	231..355	CDD:238125	52/189 (28%)
		ANK repeat	235..266	CDD:293786	11/63 (17%)
		Ank_2	240..332	CDD:289560	39/124 (31%)
		ANK repeat	268..299	CDD:293786	16/30 (53%)
		ANK repeat	301..332	CDD:293786	12/30 (40%)
		Ank_2	306..398	CDD:289560	35/125 (28%)
		ANK	329..454	CDD:238125	41/158 (26%)
		ANK repeat	334..362	CDD:293786	11/27 (41%)
		ANK repeat	367..398	CDD:293786	10/31 (32%)
		ANK repeat	400..431	CDD:293786	9/30 (30%)
		Ank_4	401..454	CDD:290365	15/52 (29%)
		ANK	428..553	CDD:238125	42/160 (26%)
		ANK repeat	435..464	CDD:293786	11/59 (19%)
		Ank_2	438..530	CDD:289560	28/124 (23%)
		ANK repeat	466..497	CDD:293786	9/32 (28%)
		ANK repeat	499..530	CDD:293786	9/30 (30%)
		Ank_5	518..575	CDD:290568	21/59 (36%)
		KAP_NTPase	605..1136	CDD:284995	78/428 (18%)
		SAM_superfamily	1357..1392	CDD:188886
ANKRD28	NP_001336206.1	ANK repeat	45..71	CDD:293786	7/26 (27%)
		PHA03095	55..>343	CDD:222980	80/288 (28%)
		ANK repeat	73..104	CDD:293786	8/30 (27%)
		ANK repeat	109..137	CDD:293786	10/27 (37%)
		ANK repeat	139..170	CDD:293786	0/30 (0%)
		ANK repeat	173..203	CDD:293786	16/29 (55%)
		ANK repeat	205..236	CDD:293786	12/30 (40%)
		ANK repeat	238..269	CDD:293786	0/30 (0%)
		PHA03095	252..>508	CDD:222980	67/255 (26%)
		ANK repeat	271..302	CDD:293786	12/30 (40%)
		ANK repeat	304..335	CDD:293786	10/30 (33%)
		ANK repeat	338..369	CDD:293786	9/30 (30%)
		ANK repeat	371..396	CDD:293786	7/24 (29%)
		ANK repeat	404..435	CDD:293786	2/30 (7%)
		ANK repeat	437..468	CDD:293786	8/30 (27%)
		ANK repeat	470..501	CDD:293786	9/30 (30%)
		ANK repeat	503..535	CDD:293786	14/36 (39%)
		Ank_2	508..613	CDD:403870	33/158 (21%)
		ANK repeat	585..613	CDD:293786	4/27 (15%)
		PHA02874	587..>896	CDD:165205	61/342 (18%)
		ANK repeat	615..646	CDD:293786	4/30 (13%)
		ANK repeat	651..683	CDD:293786	5/31 (16%)
		ANK repeat	685..716	CDD:293786	5/30 (17%)
		ANK repeat	718..749	CDD:293786	7/30 (23%)
		ANK repeat	751..780	CDD:293786	6/34 (18%)
		ANK repeat	855..886	CDD:293786	6/34 (18%)
		Ank_2	860..953	CDD:403870	14/63 (22%)
		ANK repeat	888..920	CDD:293786	6/31 (19%)
		ANK repeat	922..953	CDD:293786
		ANK repeat	958..989	CDD:293786
		Ank	960..990	CDD:394980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910